Integrated insights from simulation, experiment, and mutational analysis yield new details of LacI function

Biochemistry

Volumn 44, Issue 33, 2005, Pages 11201-11213

  Swint Kruse, Liskin ^a,b   Zhan, Hongli ^b   Matthews, Kathleen Shive ^a,b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPROXIMATION THEORY; COMPUTER SIMULATION; CONFORMATIONS; CORRELATION METHODS; DIMERS; HYDROPHOBICITY; MOLECULAR DYNAMICS;

BIOCHEMICAL CONFIRMATION; END-STATE STRUCTURES; MUTANTS; TARGETED MOLECULAR DYNAMICS (TMD);

PROTEINS;

DIMER; LACTOSE REPRESSOR LACI; MUTANT PROTEIN; REPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; EQUILIBRIUM CONSTANT; HYDROPHOBICITY; KINETICS; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN VARIANT; SIGNAL TRANSDUCTION; SIMULATION; WILD TYPE;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; DNA, BACTERIAL; ISOPROPYL THIOGALACTOSIDE; KINETICS; LAC OPERON; POINT MUTATION; PROTEIN BINDING; REPRESSOR PROTEINS;

EID: 23944464891     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050404+     Document Type: Article

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