Allosteric transition pathways in the lactose repressor protein core domains: Asymmetric motions in a homodimer

Protein Science

Volumn 12, Issue 11, 2003, Pages 2523-2541

  Flynn, Terence C ^a   Swint Kruse, Liskin ^b,c   Kong, Yifei ^c   Booth, Christopher ^c   Matthews, Kathleen S ^b   Ma, Jianpeng ^a,b,c  

^a Rice University   (United States)

^b RICE UNIVERSITY   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Allosteric mechanism; Conformational transition pathway; Gene regulation; Structural flexibility; Targeted molecular dynamics

Indexed keywords

LACTOSE; REPRESSOR PROTEIN;

ALLOSTERISM; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING KINETICS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DNA BINDING; GENE CONTROL; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SIMULATION;

ALLOSTERIC REGULATION; BACTERIAL PROTEINS; BINDING SITES; DIMERIZATION; DNA; GALACTOSIDES; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS;

EID: 0142179045     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.03188303     Document Type: Article

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