Simulation of large-scale production of a soluble recombinant protein expressed in Escherichia coli using an intein-mediated purification system

Applied Biochemistry and Biotechnology

Volumn 126, Issue 2, 2005, Pages 93-117

  Sharma, Shamik S ^a   Chong, Shaorong ^b   Harcum, Sarah W ^a  

^a South   (United States)

^b NEW ENGLAND BIOLABS   (United States)

Author keywords

Chitin; Economic analysis; Intein; Process simulation; Recombinant protein production

Indexed keywords

CHITIN; COMPUTER SIMULATION; COSTS; ESCHERICHIA COLI; OPTIMIZATION; PURIFICATION; RESINS; SUBSTRATES; COST REDUCTION; ECONOMIC ANALYSIS; RECOMBINANT PROTEINS;

ECONOMIC ANALYSIS; INTEIN; PROCESS SIMULATION; RECOMBINANT PROTEIN PRODUCTION;

PROTEINS; RESINS;

CHITIN; DITHIOTHREITOL; INTEIN; RECOMBINANT PROTEIN;

ARTICLE; CLINICAL RESEARCH; COMPARATIVE STUDY; ENZYME SUBSTRATE; ESCHERICHIA COLI; LARGE SCALE PRODUCTION; PARTICLE SIZE; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SIMULATION;

CHITIN; COMPUTER SIMULATION; DITHIOTHREITOL; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; INDUSTRIAL MICROBIOLOGY; INTEINS; MOLECULAR WEIGHT; RECOMBINANT FUSION PROTEINS; SOFTWARE; SOLUBILITY; TEMPERATURE; TROMETHAMINE;

ESCHERICHIA COLI;

DITHIOTHREITOL; ECONOMICS ANALYSIS; INTEINS; LARGE SCALE PRODUCTIONS; PROCESS SIMULATIONS; PROPERTY; PURIFICATION PROCESS; PURIFICATION SYSTEMS; RECOMBINANT PROTEIN PRODUCTIONS; TARGET PROTEINS;

EID: 23944463921     PISSN: 02732289     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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