Process simulation for recombinant protein production: Cost estimation and sensitivity analysis for heparinase I expressed in Escherichia coli

Biotechnology and Bioengineering

Volumn 53, Issue 6, 1997, Pages 575-582

  Ernst, Steffen ^a   Garro, Oscar A ^a,b   Winkler, Stefan ^a   Venkataraman, Ganesh ^c   Langer, Robert ^a,c   Cooney, Charles L ^a   Sasisekharan, Ram ^d  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b UNIVERSIDAD NACIONAL DEL NORDESTE   (Argentina)

^c HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

bioprocess simulation; Escherichia coli; heparinase; recombinant protein production

Indexed keywords

BIOTECHNOLOGY; COMPUTER SIMULATION; COST EFFECTIVENESS; COSTS; ESTIMATION; PERTURBATION TECHNIQUES; PRODUCTION; SENSITIVITY ANALYSIS;

BIOPROCESSING; ESCHERICHIA COLI; HEPARINASE; PROCESS SIMULATION; RECOMBINANT PROTEIN PRODUCTION;

PROTEINS;

HEPARIN LYASE; RECOMBINANT PROTEIN;

ARTICLE; BIOPROCESS; COMPUTER SIMULATION; COST CONTROL; COST EFFECTIVENESS ANALYSIS; DRUG MANUFACTURE; ESCHERICHIA COLI; FERMENTATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FOLDING; SOLUBILITY;

ESCHERICHIA COLI; FLAVOBACTERIUM HEPARINUM;

EID: 1842339902     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19970320)53:6<575::AID-BIT5>3.0.CO;2-J     Document Type: Article

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