1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: Synthesis, biological evaluation, and molecular modeling study

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 19, 2005, Pages 5536-5549

  Varano, Flavia ^a   Catarzi, Daniela ^a   Colotta, Vittoria ^a   Calabri, Francesca Romana ^a   Lenzi, Ombretta ^a   Filacchioni, Guido ^a   Galli, Alessandro ^a   Costagli, Chiara ^a   Deflorian, Francesca ^b   Moro, Stefano ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

AMPA receptor antagonists; Gly NMDA receptor antagonists; Ionotropic glutamate receptors; Pyrazoloquinazoline derivatives

Indexed keywords

1,8 DICHLORO 5,6 DIHYDRO 5 OXOPYRAZOLO[1,5 C]QUINAZOLINE 2 CARBOXYLIC ACID; 1,8,9 TRICHLORO 5,6 DIHYDRO 5 OXOPYRAZOLO[1,5 C]QUINAZOLINE 2 CARBOXYLIC ACID; 8 CHLORO 5,6 DIHYDRO 5 OXOPYRAZOLO[1,5 C]QUINAZOLINE 1,2 DICARBOXYLIC ACID; 8,9 DICHLORO 5,6 DIHYDRO 5 OXOPYRAZOLO[1,5 C]QUINAZOLINE 1,2 DICARBOXYLIC ACID; AMPA RECEPTOR; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; QUINAZOLINE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIPOPHILICITY; MOLECULAR MODEL; RECEPTOR AFFINITY; SUBSTITUTION REACTION;

BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; QUINAZOLINES; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23944442265     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.010     Document Type: Article

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