Cycloalkyl indole-2-carboxylates as useful tools for mapping the 'North- Eastern' region of the glycine binding site associated with the NMDA receptor

Archiv der Pharmazie

Volumn 332, Issue 3, 1999, Pages 73-80

  Micheli, Fabrizio ^a   Di Fabio, Romano ^a   Capelli, Anna M ^a   Cugola, Alfredo ^a   Curcuruto, Ornella ^a   Feriani, Aldo ^a   Gastaldi, Paola ^a   Gaviraghi, Giovanni ^a   Marchioro, Carla ^a   Orlandi, Alessandra ^a   Pozzan, Alfonso ^a   Quaglia, Anna M ^a   Reggiani, Angelo ^a   Van Amsterdam, Frank ^a  

^a GSK   (Italy)

Author keywords

Molecular modelling mechanics; Neuroprotective agents; Neurotransmitters

Indexed keywords

2 INDOLECARBOXYLIC ACID; 3 [2 (1 ADAMANTYLAMINOCARBONYL)ETHENYL] 4,6 DICHLOROINDOLE 2 CARBOXYLIC ACID; 3 [2 (NORBORNYLAMINOCARBONYL)ETHENYL] 4,6 DICHLOROINDOLE 2 CARBOXYLIC ACID; AMPA RECEPTOR; ANTICONVULSIVE AGENT; GAVESTINEL; GLYCINE; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG BINDING SITE; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; MOLECULAR MODEL; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN DOMAIN; REACTION ANALYSIS; RECEPTOR AFFINITY; SEIZURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMANTADINE; ANIMALS; ANTICONVULSANTS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; INDOLES; LIGANDS; MICE; MODELS, MOLECULAR; N-METHYLASPARTATE; NORBORNANES; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES;

EID: 0032931658     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4184(19993)332:3<73::AID-ARDP73>3.0.CO;2-5     Document Type: Article

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