7-chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1,5-a]quinox aline-2-carboxylates as novel highly selective AMPA receptor antagonists [3]

Journal of Medicinal Chemistry

Volumn 43, Issue 21, 2000, Pages 3824-3826

  Catarzi, D ^a   Colotta, V ^a   Varano, F ^a   Cecchi, L ^a   Filacchioni, G ^a   Galli, A ^a   Costagli, C ^a   Carla, V ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 4,5 DIHYDRO 8 (1,2,4 TRIAZOL 4 YL) 4 OXO 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 2 CARBOXYLIC ACID DERIVATIVE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; LETTER; MOUSE; NONHUMAN; STRUCTURE ANALYSIS;

ANIMALS; CEREBRAL CORTEX; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; MICE; QUINOXALINES; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 0034687251     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0009686     Document Type: Letter

References (14)

1. Glutamate in CNS disorders: A revived target for drug development?
2. Molecular biology of glutamate receptors in the central nervous system and their role in the excitotoxicity, oxidative stress and aging
3. Glycine-site NMDA receptor antagonists
4. Glycine-site NMDA receptor antagonists: An update
5. AMPA receptor agonists, antagonists and modulators: Their potential for clinical utility
6. AMPA receptor antagonists
7. 4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones: Excitatory amino acid antagonists with combined glycine/ NMDA and AMPA receptor affinity
8. 8-(1H-imidazol-1-yl)-7-nitro-4-(5H)-imidazo[1,2-a]quinoxalinone and related compounds: Synthesis and structure-activity relationships for the AMPA-type non-NMDA receptor
9. 6-(1H-Imidazol-1-yl)-7-nitro-2,3-(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: Structure-activity relationships for the AMPA-type non-NMDA receptor
10. Preparation of imidazoquinoxalinones as glutamate receptor antagonists
11. Cardiotonic agents. Synthesis and cardiovascular properties of novel 2-arylbenzimidazoles and azabenzimidazoles
12. Synthesis and biological evaluation of a series of quinazoline-2-carboxylic acids and quinazoline-2,4-diones as glycine-NMDA antagonists: A pharmacophore model based approach
13. Studies on receptor-active conformations of excitatory amino acid agonists and antagonists
14. Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations