8-(1H-imidazol-1-yl)-7-nitro-4(5H)-imidazo[1,2-a]quinoxalinone and related compounds: Synthesis and structure-activity relationships for the AMPA-type non-NMDA receptor

Journal of Medicinal Chemistry

Volumn 40, Issue 13, 1997, Pages 2053-2063

  Ohmori, Junya ^a   Shimizu Sasamata, Masao ^a   Okada, Masamichi ^a   Sakamoto, Shuichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; 8 (1H IMIDAZOL 1 YL) 7 NITRO 4(5H) IMIDAZO[1,2 A]QUINOXALINONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMIDE; AMPA RECEPTOR; DRUG CARRIER; GLYCINE; HYDROGEN; IMIDAZOLE; NITROGEN; QUINOXALINE DERIVATIVE; TRIAZOLE; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; DRUG SYNTHESIS; EMBRYO; HYDROGEN BOND; NEUROTOXICITY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING, COMPETITIVE; DRUG DESIGN; IMIDAZOLES; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; QUINOXALINES; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030988859     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960664c     Document Type: Article

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