Human CD81 directly enhances Th1 and Th2 cell activation, but preferentially induces proliferation of Th2 cells upon long-term stimulation

BMC Immunology

Volumn 4, Issue , 2003, Pages

  Maecker, Holden T ^a  

^a BD BIOSCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; CD81 ANTIGEN; CELL SURFACE PROTEIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; POLYCLONAL ANTIBODY; SUPERANTIGEN; TETRASPANIN;

ANTIGEN EXPRESSION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; PROTEIN FAMILY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

EID: 2542505658     PISSN: 14712172     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2172-4-1     Document Type: Article

References (33)

1. Maecker HT, Todd SC and Levy S The tetraspanin superfamily: molecular facilitators Faseb J 1997, 11:428-442
2. Levy S, Todd SC and Maecker HT CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system Annu Rev Immunol 1998, 16:89-109
3. Fearon DT and Carter RH The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity Annu Rev Immunol 1995, 13:127-149
4. Schick MR and Levy S The TAPA-1 molecule is associated on the surface of B cells with HLA-DR molecules J Immunol 1993, 151:4090-4097
5. Angelisov P, Hilgert I and Horejs V Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins Immunogenetics 1994, 39:249-256
6. Szollosi J, Horejsi V, Bene L, Angelisova P and Damjanovich S Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY J Immunol 1996, 157:2939-2946
7. Imai T, Fukudome K, Takagi S, Nagira M, Furuse M, Fukuhara N, Nishimura M, Hinuma Y and Yoshie O C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63 J Immunol 1992, 149:2879-2886
8. Imai T, Kakizaki M, Nishimura M and Yoshie O Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82 J Immunol 1995, 155:1229-1239
9. Mannion BA, Berditchevski F, Kraeft SK, Chen LB and Hemler ME Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29) J Immunol 1996, 157:2039-2047
10. Todd SC, Lipps SG, Crisa L, Salomon DR and Tsoukas CD CD81 expressed on human thymocytes mediates integrin activation and IL-2-dependent proliferation J. Exp. Med 1996, 184:2055-2060
11. Oren R, Takahashi S, Doss C, Levy R and Levy S TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins Mol Cell Biol 1990, 10:4007-4015
12. Drenou B, Blancheteau V, Burgess DH, Fauchet R, Charron DJ and Mooney NA A caspase-independent pathway of MHC class II antigen-mediated apoptosis of human B lymphocytes J Immunol 1999, 163:4115-4124
13. Takahashi S, Doss C, Levy S and Levy R TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen J Immunol 1990, 145:2207-2213
14. Behr S and Schriever F Engaging CD19 or target of an antiproliferative antibody 1 on human B lymphocytes induces binding of B cells to the interfollicular stroma of human tonsils via integrin alpha 4/beta 1 and fibronectin J Exp Med 1995, 182:1191-1199
15. Dempsey PW, Allison ME, Akkaraju S, Goodnow CC and Fearon DT C3d of complement as a molecular adjuvant: bridging innate and acquired immunity Science 1996, 271:348-350
16. Witherden DA, Boismenu R and Havran WL CD81 and CD28 costimulate T cells through distinct pathways J Immunol 2000, 165:1902-1909
17. VanCompernolle SE, Levy S and Todd SC Anti-CD81 activates LFA-1 on T cells and promotes T cell-B cell collaboration Eur J Immunol 2001, 31:823-831
18. Boismenu R, Rhein M, Fischer WH and Havran WL A role for CD81 in early T cell development Science 1996, 271:198-200
19. Secrist H, Levy S, DeKruyff RH and Umetsu DT Ligation of TAPA-1 (CD81) or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4+ T cells Eur J Immunol 1996, 26:1435-1442
20. Maecker HT and Levy S Normal lymphocyte development but delayed humoral immune response in CD81-null mice J Exp Med 1997, 185:1505-1510
21. Maecker HT, Do MS and Levy S CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses Proc Natl Acad Sci U S A 1998, 95:2458-2462
22. Deng J, Yeung VP, Tsitoura D, DeKruyff RH, Umetsu DT and Levy S Allergen-induced airway hyperreactivity is diminished in CD81-deficient mice J Immunol 2000, 165:5054-5061
23. Deng J, Dekruyff RH, Freeman GJ, Umetsu DT and Levy S Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses Int Immunol 2002, 14:513-523
24. Bajenoff M, Wurtz O and Guerder S Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4(+) T cells J Immunol 2002, 168:1723-1729
25. Murphy E, Shibuya K, Hosken N, Openshaw P, Maino V, Davis K, Murphy K and O'Garra A Reversibility of T helper 1 and 2 populations is lost after long-term stimulation J Exp Med 1996, 183:901-913
26. Vinay DS and Kwon BS Relative abilities of 4-1BB (CD137) and CD28 to co-stimulate the response of cytokine deflected Th1 and Th2 cells Immunobiology 1999, 200:246-263
27. Kishimoto K, Dong VM, Issazadeh S, Fedoseyeva EV, Waaga AM, Yamada A, Sho M, Benichou G, Auchincloss H., Jr., Grusby MJ, Khoury SJ and Sayegh MH The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo J Clin Invest 2000, 106:63-72
28. Rogers PR and Croft M CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen J Immunol 2000, 164:2955-2963
29. Walter H, Schepensn S, Van Wauwe J and de Boer M Ligation of CD28 on resting T cells by its ligand B7 results in the induction of both Th1- and Th2-type cytokines Eur Cytokine Netw 1994, 5:13-21
30. Maecker H and Raychaudhuri S Modified immunoprecipitation for determining chain specificity of antibodies to disulfide linked proteins FOCIS 1993, 15:116-119
31. Suni MA, Picker LJ and Maino VC Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometry J Immunol Methods 1998, 212:89-98
32. Nomura LE, Walker JM and Maecker HT Optimization of whole blood antigen-specific cytokine assays for CD4(+) T cells Cytometry 2000, 40:60-68
33. Mehta BA and Maino VC Simultaneous detection of DNA synthesis and cytokine production in staphylococcal enterotoxin B activated CD4+ T lymphocytes by flow cytometry J Immunol Methods 1997, 208:49-59