Interferon-alpha is effective in HTLV-I-associated myelopathy: A multicenter, randomized, double-blind, controlled trial

Neurology

Volumn 46, Issue 4, 1996, Pages 1016-1021

  Izumo, S ^a   Goto, I ^b   Itoyama, Y ^b   Okajima, T ^c   Watanabe, S ^d   Kuroda, Y ^e   Araki, S ^f   Mori, M ^g   Nagataki, S ^h   Matsukura, S ⁱ   Akamine, T ^j   Nakagawa, M ^k   Yamamoto, I ^l   Osame, M ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c OITA UNIVERSITY   (Japan)

^d KARATSU RED CROSS HOSPITAL   (Japan)

^e SAGA UNIVERSITY   (Japan)

^f KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^g Nagasaki Chuo National Hospital   (Japan)

^h NAGASAKI UNIVERSITY   (Japan)

ⁱ UNIVERSITY OF MIYAZAKI   (Japan)

^j MIYAZAKI PREFECTURAL MIYAZAKI HOSPITAL   (Japan)

^k National Hospital Organization Okinawa National Hospital   (Japan)

^l OKAYAMA UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON;

ADULT; AGED; ANOREXIA; ARTHRALGIA; ARTICLE; CHILD; CHILL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FEVER; FLUSHING; HEADACHE; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; MAJOR CLINICAL STUDY; MALAISE; MALE; MICTURITION DISORDER; MOTOR DYSFUNCTION; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPINAL CORD DISEASE; XEROSTOMIA;

EID: 9244260516     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.46.4.1016     Document Type: Article

References (27)

1. Gessain A, Barin F, Vernant JC, et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985;2:407-410.
2. Rodgers-Johnson P, Gajdusek DC, Morgan OS, et al. HTLV-I and HTLV-III antibodies and tropical spastic paraparesis. Lancet 1985;2:1247-1248.
3. Osame M, Usuku K, Izumo S, et al. HTLV-I associated myelopathy, a new clinical entity. Lancet 1986;1:1031.
4. Osame M, Matsumoto M, Usuku K, et al. Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemia like cells. Ann Neurol 1987;21:117-122.
5. Roman GC, Osame M. Identity of HTLV-I-associated tropical spastic paraparesis and HTLV-I-associated myelopathy. Lancet 1988;1:651.
6. World Health Organization. Report of the scientific group on HTLV-I and associated diseases, Kagoshima, Japan, December 1988. Available from Manila, Philippines: World Health Organization, March 1989; Virus Diseases. Human T-lymphotropic virus type I, HTLV-I (Abstract). WHO Weekly Epidemiol Rec 1989;49:382-383.
7. World Health Organization. Report of the scientific group on HTLV-I and associated diseases, Kagoshima, Japan, December 1988. Available from Manila, Philippines: World Health Organization, March 1989; Virus Diseases. Human T-lymphotropic virus type I, HTLV-I (Abstract). WHO Weekly Epidemiol Rec 1989;49:382-383.
8. Osame M, Igata A, Matsumoto M, et al. HTLV-I-associated myelopathy (HAM). Treatment trials, retrospective survey, and clinical and laboratory findings. Hematol Rev 1990;3:271-284.
9. Itoyama Y, Minato S, Kira J, et al. Altered subsets of peripheral blood lymphocytes in patients with HTLV-I associated myelopathy (HAM). Neurology 1988;38:816-818.
10. Mori M, Kinoshita K, Ban N, Yamada Y, Shiku H. Activated T-lymphocytes with polyclonal gammopathy in patients with human T-lymphotropic virus type I-associated myelopathy. Ann Neurol 1988;24:280-282.
11. Ijichi S, Eiraku N, Osame M, et al. Activated T lymphocytes in cerebrospinal fluid of patients with HTLV-I-associated myelopathy (HAM/TSP). J Neuroimmunol 1989;25:251-254.
12. Usuku K, Sonoda S, Osame M, et al. HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: comparison with adult T-cell leukemia/lymphoma. Ann Neurol 1988;23(Suppl):143-150.
13. Itoyama Y, Minato S, Kira J, et al. Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV-I-associated myelopathy. Neurology 1988;38:1302-1307.
14. Ijichi S, Eiraku N, Osame M, et al. In vitro modulation of lymphocyte proliferation by prednisolone and interferon-alpha in patients with HTLV-I-associated myelopathy (HAM). J Neuroimmunol 1989;23:175-178.
15. Eiraku N, Ijichi S, Yashiki S, Osame M, Sonoda S. Cell surface phenotype of in vivo proliferating lymphocytes in HTLV-I-associated myelopathy (HAM/TSP). J Neuroimmunol 1992; 37:223-228.
16. Matsuo H, Nakamura T, Tsujihata M, et al. Plasmapheresis in treatment of human T-lymphotropic virus type-I associated myelopathy. Lancet 1988;2:1109-1113.
17. Matsuo H, Nakamura T, Shibayama K, et al. Long-term follow-up of immunomodulation in treatment of HTLV-I-associated myelopathy. Lancet 1989;1:790.
18. Izumo S, Usuku K, Osame M, Arimura K, Igata A. Effect of alpha-interferon treatment on HTLV-I associated myelopathy (HAM) [Abstract]. Neurology 1988;39(Suppl):242.
19. Kuroda Y, Takashima H, Endo C, et al. Treatment of HTLV-I-associated myelopathy with α-interferon and high dose of γ-globulin. Clin Neurol (Tokyo) 1990;30:594-598.
20. Nakamura T, Shibayama K, Nagasato K, et al. The efficacy of interferon-alpha treatment in human T-lymphotropic virus type-I associated myelopathy. Jpn J Med 1990;29:362-367.
21. Knobler RL, Panitch HS, Braheny SL, et al. Systemic alpha-interferon therapy of multiple sclerosis. Neurology 1984;34: 1273.
22. Panitch HS, Gomez-Plascencia J, Norris FH, et al. Subacute sclerosing panencephalitis: remission after treatment with intraventricular interferon. Neurology 1986;36:562-566.
23. Lane HC, Kovacs JA, Feinberg J, et al. Anti-retroviral effects of interferon-α in AIDS-associated Kaposi's sarcoma. Lancet 1988;2:1218.
24. Brook MG, Gor D, Forster SM, et al. Suppression of HIV p24 antigen and induction of HIV anti-p24 antibody by alpha-interferon in patients with chronic hepatitis. AIDS 1988;2: 391-393.
25. Ichimaru M, Kamihira S, Moriuchi Y, et al. Clinical study on the effect of natural α-interferon (HLBI) in the treatment of adult T-cell leukemia. Jpn J Cancer Chemother 1988;15: 2975-2981.
26. Nishida J, Yoshikura H, Okabe T, et al. Interferons inhibit syncytiaforming ability and in vitro transmission of human T-cell leukemia virus. Jpn J Cancer Res 1985;76:249-252.
27. Umehara F, Izumo S, Nakagawa M, et al. Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy. J Neuropathol Exp Neurol 1993;52:424-430.