Astrocytes produce dendritic cell-attracting chemokines in vitro and in multiple sclerosis lesions

Journal of Neuropathology and Experimental Neurology

Volumn 64, Issue 8, 2005, Pages 706-715

  Ambrosini, Elena ^a   Remoli, Maria Elena ^a   Giacomini, Elena ^a   Rosicarelli, Barbara ^a   Serafini, Barbara ^a   Lande, Roberta ^a   Aloisi, Francesca ^a   Coccia, Eliana Marina ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Central nervous system; Chemokines; Dendritic cells; Glial cells; Inflammation

Indexed keywords

CCL 20 CHEMOKINE; CCL 3 CHEMOKINE; CCL 4 CHEMOKINE; CCL 5 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RNA; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; CELL MIGRATION; CENTRAL NERVOUS SYSTEM; CHEMOTAXIS; CONTROLLED STUDY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; MONOCYTE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 23844487401     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jnen.0000173893.01929.fc     Document Type: Article

References (71)

1. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Ann Rev Immunol 2000;18:767-811
2. Steinmann RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003;21:685-711
3. Lanzavecchia A, Sallusto F. Regulation of T cell immunity by dendritic cells. Cell 2001;106:263-66
4. Groux H, Fournier N, Cottrex F. Role of dendritic cells in the generation of regulatory T cells. Semin Immunol 2004;16:99-106
5. McMenamin PG. Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations. J Comp Neurol 1999;405:553-62
6. Weller RO, Engelhardt B, Phillips MJ. Lymphocyte targeting of the central nervous system: A review of afferent and efferent CNS-immune pathways. Brain Pathol 1996;6:275-88
7. Perry VH. A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation. J Neuroimmunol 1998;90:113-21
8. Matyszak MK, Perry VH. The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system. Neuroscience 1996;74:599-608
9. Fischer HG, Bonifas U, Reichmann G. Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii. J Immunol 2000;164:4826-34
10. Kostulas N, Li HL, Xiao BG, Huang YM, et al. Dendritic cells are present in ischemic brain after permanent middle cerebral artery occlusion in the rat. Stroke 2002;33:1129-34
11. Reichmann G, Schroeter M, Jander S, et al. Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain. J Neuroimmunol 2002;129:125-32
12. Henkel JS, Engelhardt JI, Siklos L, et al. Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann Neurol 2004;55:221-35
13. Plumb J, Armstrong MA, Duddy M, et al. CD83-positive dendritic cells are present in occasional perivascular cuffs in multiple sclerosis lesions. Mult Scler 2003;9:142-47
14. Kwisakk P, Mahad DJ, Callahan MK, et al. Expression of CCR7 in multiple sclerosis lesions: Implications for CNS immunity. Ann Neurol 2004;55:627-38
15. Serafini B, Rosicarelli B, Magliozzi R, Capello E, Mancardi GL, Aloisi F. Immature and mature dendritic cells in multiple sclerosis lesions. J Neuroimmunol 2004;154:90
16. Serafini B. Columba-Cabezas S, Di Rosa F, et al. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am J Pathol 2000;157:1991-2002
17. Suter T, Malipiero U, Otten L, et al. Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis. Eur J Immunol 2000;30:794-802
18. Pashenkov M, Huang YM, Kostulas V, Haglund M, Soderstrom M, Link H. Two subset of dendritic cells are present in human cerebrospinal fluid. Brain 2001;124:480-92
19. Karman J, Ling C, Sandor M, et al. Initiation of immune responses in brain is promoted by local dendritic cells. J Immunol 2004;73:2353-61
20. Gerard C, Rollins BJ. Chemokines and disease. Nat Immunol 2001;2:108-15
21. Campbell DJ, Kim CH, Butcher EC. Chemokines in the systemic organization of immunity. Immunol Rev 2003;195:58-71
22. Moser B, Wolf M, Walz A. et al. Chemokines: Multiple levels of leukocyte migration control. Trends Immunol 2004;25:75-84
23. Xu LL, Warren MK, Rose WL, et al. Human recombinant monocyte chemotactic protein and other C-C Chemokines bind and induce directional migration of dendritic cells in vitro. J Leukoc Biol 1996;60:365-71
24. Sozzani S, Luini W, Borsatti A, et al. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. J Immunol 1997;159:1993-2000
25. Vecchi A, Massimiliano L, Ramponi S, et al. Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells. J Leuk Biol 1999;64:489-94
26. Dieu-Nosjean MC, Vicari A, Lebecque S, et al. Regulation of dendritic cell trafficking: A process that involves participation of selective chemokines. J Leuk Biol 1999;66:252-62
27. Caux C, Ait-Yahia S, Chemin K. Dendritic cell biology and regulation of dendritic cell trafficking by chemokines. Semin Immunopathol 2000;22:345-69
28. Vulcano M, Struyf S, Scapini P, et al. Unique regulation of CCL18 production by maturing dendritic cells. J Immunol 2003;170:3843-49
29. Dieu MC, Vanbervliet B, Vicari A. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 1998;188:373-86
30. Sozzani S, Allavena P, D'Amico G, et al. Differential regulation of chemokine receptors during dendritic cell maturation: A model for their trafficking properties. J Immunol 1998;161:1083-86
31. Glabinski AR, Ransohoff RM. Chemokines and chemokine receptors in CNS pathology. J Neurovirol 1999;5:3-12
32. Ambrosini E, Aloisi F. Chemokines and glial cells a complex network in the central nervous system. Neurochem Res 2004;29:1017-38
33. Aloisi F, Borsellino G, Samoggia P, et al. Astrocyte cultures from human embryonic brain: Characterization and modulation of surface molecules by inflammatory cytokines. J Neurosci Res 1992;32:494-506
34. Lande R, Giacomini E, Grassi T, et al. IFN-alpha beta released by Mycobacterium tuberculosis-infected human dendritic cells induces the expression of CXCL10: Selective recruitment of NK and activated T cells. J Immunol 2003;170:1174-82
35. De Groot CJ, Berges E, Amphorst W, et al. Post-mortem MRI-guided sampling of multiple sclerosis lesions: Increased yield of demyelinating and (pre)active lesions. Brain 2001;124:1635-45
36. Aloisi F. Cytokine production. In: Kettenmann H, Ransom BR, eds. Neuroglia. New York: Oxford University Press. 2005:285-301
37. Columba-Cabezas S, Serafini B, Ambrosini E, et al. Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia: implications for disease regulation. J Neuroimmunol 2002;130:10-21
38. Godiska R, Chantry D, Raport CJ, et al. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J Exp Med 1997;185:1595-604
39. Delgado E, Finkel V, Baggiolini M, Mackay CR, Steinmam RM, Granelli-Piperno A. Mature dendritic cells respond to SDF-1 but not to several beta-chemokines. Immunobiology 1998;198:490-50
40. Palma C, Minghetti L, Astolfi M, et al. Functional characterization of substance P receptors on cultured human spinal cord astrocytes: Synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production. Glia 1997;21:183-93
41. Sato K, Kawasaki H, Nagayama H, et al. CC chemokine receptors, CCR-1 and CCR-3, are potentially involved in antigen-presenting cell function of human peripheral blood monocyte-derived dendritic cells. Blood 1999;93:34-42
42. Beaulieu S, Robbiani DF, Du X, et al. Expression of a functional eotaxin (CC chemokine ligand 11) receptor CCR3 by human dendritic cells. J Immunol 2002;169:2925-36
43. Greaves DR, Wang W, Dairaghi DJ, et al. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. J Exp Med 1997;186:837-44
44. Sato K, Kawasaki H, Nagayama H, et al. TGF-β1 reciprocally controls chemotaxis of human peripheral blood monocyte-derived dendritic cells via chemokine receptors. J Immunol 2000;164:2285-95
45. Carramolino L, Kremer L, Goya I, et al. Down-regulation of the beta-chemokine receptor CCR6 in dendritic cells mediated by TNF-alpha and 1L-4. J Leukoc Biol 1999;66:837-44
46. Dieu-Nosjean MC, Massacrier C, Vanbervliet B, et al. IL-10 induces CCR6 expression during Langerhans cell development while IL-4 and IFN-gamma suppress it. J Immunol 2001;167:5594-602
47. Hemmer B, Kieseier B, Cepok S, et al. New immunopathologic insights into multiple sclerosis. Curr Neurol Neurosci Rep 2003;3:246-55
48. Aloisi F, Ambrosini E, Columba-Cabezas S, et al. Intracerebral regulation of immune responses. Ann Med 2001;33:510-15
49. Pashenkov M, Telesova N, Link H. Inflammation in the central nervous system: The role for dendritic cells. Brain Pathol 2003;12:23-3
50. Middleton J, Patterson AM, Gardner L, et al. Leukocyte extravasation: Chemokine transport and presentation by the endothelium. Blood 2002;100:3853-60
51. Tanaka Y, Imai T, Baba M, et al. Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans. Eur J Immunol 1999;29:633-42
52. Liao F, Rabin RL, Smith CS, Sharma G, Nutman TB, Farber JM. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J Immunol 1999;162:186-94
53. Krzysiek R, Lefevre EA, Bernard J, et al. Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha/CCL20 in human B cells. Blood 2000;96:2338-45
54. Matsui T, Akahoshi T, Namai R, et al. Selective recruitment of CCR6-expressing cells by increased production of MIP-3 alpha in rheumatoid arthritis. Clin Exp Immunol 2001;125:155-61
55. Page G, Lebecque S, Miossec P. Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: Correlation with selective chemokine expression in rheumatoid synovium. J Immunol 2002;168:5333-41
56. Homey B, Dieu-Nosjean MC, Wiesenborn A, et al. Up-regulation of macrophage inflammatory protetn-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 2000;15;164:6621-32
57. Schutyser E, Struyf S, Van Damme J. The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev 2003;14:409-26
58. Dieu-Nosjean MC, Massacrier C, Homey B, et al. Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med 2000;192:705-18
59. Utans-Schneitz U, Lorez H, Klinkert WEF, et al. A novel rat chemokine, identified by targeted differential display, is regulated in brain inflammation. J Neuroimmunol 1998;92:179-90
60. Ambrosini E, Columba Cabezas S, Serafini B, et al. Astrocytes are the major intracerebral source of macrophage inflammatory protein-3 alpha/CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro. Glia 2003;41:290-30
61. Kohler RE, Caon AC, Willenborg DO, et al. A role for macrophage inflammatory protein-3 alpha/CC chemokine ligand 20 in immune priming during T cell-mediated inflammation of the central nervous system. J Immunol 2003;170:6298-306
62. Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996;382:635-38
63. Aiuti A, Webb IJ, Bleul C, et al. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 1997;185:111-20
64. Lazarini F, Tham TN, Casanova P, et al. Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system. Glia 2003;15;42:139-48
65. Bajetto A, Bonavia R, Barbero S, et al. Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1. J Neurochem 1999;73:2348-57
66. Buckley CD, Amft N, Bradfield PF, et al. Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium. J Immunol 2000;165:3423-29
67. Armengol MP, Cardoso-Schmidt CB, Fernandez M, Ferrer X, Pujol-Borrell R, Juan M. Chemokines determine local lymphoneogenesis and a reduction of circulating CXCR4+ T and CCR7 B and T lymphocytes in thyroid autoimmune diseases. J Immunol 2003;15;170:6320-28
68. Bradfield PF, Amft N, Vernon-Wilson E, et al. Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue. Arthritis Rheum 2003;48:2472-82
69. Pashenkov M, Teleshova N, Kouwenhoven M, et al. Recruitment of dendritic cells to the cerebrospinal fluid in bacterial neuroinfections. J Neuroimmunol 2002;122:106-16
70. Giunti D, Borsellino G, Benelli R, et al. Phenotypic and functional analysis of T cell homing into the CSF of subjects with inflammatory diseases of the CNS. J Leuk Biol 2003;273:584-90
71. Corcione A, Casazza S, Ferretti E, et al. Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc Natl Acad Sci USA 2004;101:11064-69