Role of dendritic cells in the generation of regulatory T cells

Seminars in Immunology

Volumn 16, Issue 2, 2004, Pages 99-106

  Groux, Hervé ^a   Fournier, Nathalie ^a   Cottrez, Françoise ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

Dendritic cells; T regulatory cells; Tolerance

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL MIGRATION; DENDRITIC CELL; IMMUNOREGULATION; IN VITRO STUDY; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 1242295284     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2003.12.004     Document Type: Article

References (77)

1. Liu Y.J. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell. 106:2001;259-262.
2. Vermaelen K.Y., Carro-Muino I., Lambrecht B.N., Pauwels R.A. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193:2001;51-60.
3. Huang F.P., Platt N., Wykes M., Major J.R., Powell T.J., Jenkins C.D.et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes [see comments]. J. Exp. Med. 191:2000;435-444.
4. Groux H., Bigler M., O'Garra A., Rouleau M., Antonenko S., de Vries J.E.et al. A CD4+ T-cell subset inhibits antigen-specific T cell responses and prevents colitis. Nature. 389:1997;737-742.
5. Cottrez F., Hurst S.D., Coffman R.L., Groux H. T regulatory cells 1 inhibit a Th2-specific response in vivo [in process citation]. J. Immunol. 165:2000;4848-4853.
6. McGuirk P., McCann C., Mills K.H. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J. Exp. Med. 195:2002;221-231.
7. Chen Y., Kuchroo V.K., Inobe J.-I., Hafler D.A., Weiner H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265:1994;1237-1240.
8. Weiner H.L. Oral tolerance for the treatment of autoimmune diseases. Annu. Rev. Med. 48:1997;341-351.
9. Weiner H.L. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 182:2001;207-214.
10. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1995;1151-1164.
11. Asano M., Toda M., Sakaguchi N., Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:1996;387-396.
12. Papiernik M., de Moraes M.L., Pontoux C., Vasseur F., Penit C. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10:1998;371-378.
13. Itoh M., Takahashi T., Sakaguchi N., Kuniyasu Y., Shimizu J., Otsuka F. et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:1999;5317-5326.
14. Jordan M.S., Riley M.P., von Boehmer H., Caton A.J. Anergy and suppression regulate CD4(+) T cell responses to a self peptide. Eur. J. Immunol. 30:2000;136-144.
15. Romagnoli P., Hudrisier D., van Meerwijk J.P. Preferential recognition of self antigens despite normal thymic deletion of CD4(+)CD25(+) regulatory T cells. J. Immunol. 168:2002;1644-1648.
16. Cong Y., Weaver C.T., Lazenby A., Elson C.O. Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J. Immunol. 169:2002;6112-6119.
17. Satoguina J., Mempel M., Larbi J., Badusche M., Loliger C., Adjei O.et al. Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis). Microb. Infect. 4:2002;1291-1300.
18. Chen C., Lee W.H., Yun P., Snow P., Liu C.P. Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes. J. Immunol. 171:2003;733-744.
19. Wildbaum G., Netzer N., Karin N. Tr1 cell-dependent active tolerance blunts the pathogenic effects of determinant spreading. J. Clin. Invest. 110:2002;701-710.
20. Fairchild P.J., Waldmann H. Dendritic cells and prospects for transplantation tolerance. Curr. Opin. Immunol. 12:2000;528-535.
21. Steinman R.M., Turley S., Mellman I., Inaba K. The induction of tolerance by dendritic cells that have captured apoptotic cells [comment]. J. Exp. Med. 191:2000;411-416.
22. Jonuleit H., Schmitt E., Schuler G., Knop J., Enk A.H. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells [in process citation]. J. Exp. Med. 192:2000;1213-1222.
23. Dhodapkar M.V., Steinman R.M., Krasovsky J., Munz C., Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193:2001;233-238.
24. Hirao M., Onai N., Hiroishi K., Watkins S.C., Matsushima K., Robbins P.D.et al. CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes. Cancer Res. 60:2000;2209-2217.
25. Turley S.J., Inaba K., Garrett W.S., Ebersold M., Unternaehrer J., Steinman R.M.et al. Transport of peptide-MHC class II complexes in developing dendritic cells. Science. 288:2000;522-527.
26. Inaba K., Turley S., Yamaide F., Iyoda T., Mahnke K., Inaba M.et al. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J. Exp. Med. 188:1998;2163-2173.
27. Steinbrink K., Wolfl M., Jonuleit H., Knop J., Enk A.H. Induction of tolerance by IL-10-treated dendritic cells. J. Immunol. 159:1997;4772-4780.
28. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J.et al. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:2000;767-811.
29. Sallusto F., Cella M., Danieli C., Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182:1995;389-400.
30. Hawiger D., Inaba K., Dorsett Y., Guo M., Mahnke K., Rivera M.et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194:2001;769-779.
31. Rubartelli A., Poggi A., Zocchi M.R. The selective engulfment of apoptotic bodies by dendritic cells is mediated by the alpha(v)beta3 integrin and requires intracellular and extracellular calcium. Eur. J. Immunol. 27:1997;1893-1900.
32. Schulz O., Pennington D.J., Hodivala-Dilke K., Febbraio M., Reis e Sousa C. CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells. J. Immunol. 168:2002;6057-6065.
33. Fu F., Li Y., Qian S., Lu L., Chambers F., Starzl T.E.et al. Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation. 62:1996;659-665.
34. Lutz M.B., Suri R.M., Niimi M., Ogilvie A.L., Kukutsch N.A., Rossner S. et al. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur. J. Immunol. 30:2000;1813-1822.
35. Mommaas A.M., Mulder A.A., Out C.J., Girolomoni G., Koerten H.K., Vermeer B.J.et al. Distribution of HLA class II molecules in epidermal Langerhans cells in situ. Eur. J. Immunol. 25:1995;520-525.
36. Lee M.G., Borkowski T.A., Udey M.C. Regulation of expression of B7 by murine Langerhans cells: a direct relationship between B7 mRNA levels and the level of surface expression of B7 by Langerhans cells. J. Invest. Dermatol. 101:1993;883-886.
37. Schwartz R.H. A cell culture model for T lymphocyte clonal anergy. Science. 248:1990;1349-1356.
38. Reinhardt R.L., Khoruts A., Merica R., Zell T., Jenkins M.K. Visualizing the generation of memory CD4 T cells in the whole body. Nature. 410:2001;101-105.
39. De Smedt T., Pajak B., Muraille E., Lespagnard L., Heinen E., De Baetselier P.et al. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J. Exp. Med. 184:1996;1413-1424.
40. Dieu M.C., Vanbervliet B., Vicari A., Bridon J.M., Oldham E., Ait-Yahia S.et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 188:1998;373-386.
41. Bujdoso R., Hopkins J., Dutia B.M., Young P., McConnell I. Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage. J. Exp. Med. 170:1989;1285-1301.
42. Matsuno K., Ezaki T., Kudo S., Uehara Y. A life stage of particle-laden rat dendritic cells in vivo: their terminal division, active phagocytosis, and translocation from the liver to the draining lymph. J. Exp. Med. 183:1996;1865-1878.
43. Liu L., Zhang M., Jenkins C., MacPherson G.G. Dendritic cell heterogeneity in vivo: two functionally different dendritic cell populations in rat intestinal lymph can be distinguished by CD4 expression. J. Immunol. 161:1998;1146-1155.
44. Drexhage H.A., Mullink H., de Groot J., Clarke J., Balfour B.M. A study of cells present in peripheral lymph of pigs with special reference to a type of cell resembling the Langerhans cell. Cell Tissue Res. 202:1979;407-430.
45. Brand C.U., Hunger R.E., Yawalkar N., Gerber H.A., Schaffner T., Braathen L.R. Characterization of human skin-derived CD1a-positive lymph cells. Arch. Dermatol. Res. 291:1999;65-72.
46. Mishima Y. Melanosomes in phagocytic vacuoles in Langerhans cells. Electron microscopy of keratin-stripped human epidermis. J. Cell. Biol. 30:1966;417-423.
47. Hemmi H., Yoshino M., Yamazaki H., Naito M., Iyoda T., Omatsu Y.et al. Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-beta1-dependent cells. Int. Immunol. 13:2001;695-704.
48. Parr M.B., Kepple L., Parr E.L. Langerhans cells phagocytose vaginal epithelial cells undergoing apoptosis during the murine estrous cycle. Biol. Reprod. 45:1991;252-260.
49. Scheinecker C., McHugh R., Shevach E.M., Germain R.N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 196:2002;1079-1090.
50. Randolph G.J. Dendritic cell migration to lymph nodes: cytokines* chemokines* and lipid mediators. Semin. Immunol. 13:2001;267-274.
51. Ruedl C., Koebel P., Bachmann M., Hess M., Karjalainen K. Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes. J. Immunol. 165:2000;4910-4916.
52. Blankenstein T., Schuler T. Cross-priming versus cross-tolerance: are two signals enough? Trends Immunol. 23:2002;171-173.
53. Akbari O., DeKruyff R.H., Umetsu D.T. Pulmonary dendritic cells producing IL-10 mediate dtolerance induced by respiratory exposure to antigen. Nat. Immunol. 2:2001;725-731.
54. Christensen H.R., Frokiaer H., Pestka J.J. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J. Immunol. 168:2002;171-178.
55. Huang Y.M., Yang J.S., Xu L.Y., Link H., Xiao B.G. Autoantigen-pulsed dendritic cells induce tolerance to experimental allergic encephalomyelitis (EAE) in Lewis rats. Clin. Exp. Immunol. 122:2000;437-444.
56. Khanna A., Morelli A.E., Zhong C., Takayama T., Lu L., Thomson A.W. Effects of liver-derived dendritic cell progenitors on Th1- and Th2- like cytokine responses in vitro and in vivo. J. Immunol. 164:2000;1346-1354.
57. Iwasaki A., Kelsall B.L. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med. 190:1999;229-239.
58. Wakkach A., Fournier N., Brun V., Breittmayer J.P., Cottrez F., Groux H. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity. 18:2003;605-617.
59. Allavena P., Sica A., Vecchi A., Locati M., Sozzani S., Mantovani A. The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues. Immunol. Rev. 177:2000;141-149.
60. Lutz M., Schuler G. Immature, sem-mature and fully mature dendritic cells: which signals induce tolerance or immunity. Trends Immunol. 23:2002;445.
61. Shortman K., Liu Y.J. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2:2002;151-161.
62. Willbanks G.A., Mammolenti M., Streilein J.W. Studies on the induction of anterior chamber-associated immune deviation (ACAID) III. Induction of ACAID depends upon intraocular transforming growth factor-β Eur. J. Immunol. 22:1992;165-173.
63. Hosoi J., Murphy G.F., Egan C.L., Lerner E.A., Grabbe S., Asahina A.et al. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature. 363:1993;159-163.
64. Stumbles P.A., Thomas J.A., Pimm C.L., Lee P.T., Venaille T.J., Proksch S.et al. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J. Exp. Med. 188:1998;2019-2031.
65. Oyama T., Ran S., Ishida T., Nadaf S., Kerr L., Carbone D.P.et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J. Immunol. 160:1998;1224-1232.
66. Verhasselt V., Vanden Berghe W., Vanderheyde N., Willems F., Haegeman G., Goldman M. N-Acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition. J. Immunol. 162:1999;2569-2574.
67. Piemonti L., Monti P., Allavena P., Sironi M., Soldini L., Leone B.E.et al. Glucocorticoids affect human dendritic cell differentiation and maturation. J. Immunol. 162:1999;6473-6481.
68. Matyszak M.K., Citterio S., Rescigno M., Ricciardi-Castagnoli P. Differential effects of corticosteroids during different stages of dendritic cell maturation. Eur. J. Immunol. 30:2000;1233-1242.
69. Piemonti L., Monti P., Sironi M., Fraticelli P., Leone B.E., Dal Cin E. et al. Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells. J. Immunol. 164:2000;4443-4451.
70. Penna G., Adorini L. 1 Alpha, 25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J. Immunol. 164:2000;2405-2411.
71. Matasic R., Dietz A.B., Vuk-Pavlovic S. Cyclooxygenase-independent inhibition of dendritic cell maturation by aspirin. Immunology. 101:2000;53-60.
72. Hackstein H., Morelli A.E., Larregina A.T., Ganster R.W., Papworth G.D., Logar A.J.et al. Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dendritic cells. J. Immunol. 166:2001;7053-7062.
73. De Smedt T., Van Mechelen M., De Becker G., Urbain J., Leo O., Moser M. Effect of interleukin-10 on dendritic cell maturation and function. Eur. J. Immunol. 27:1997;1229-1235.
74. Geissmann F., Revy P., Regnault A., Lepelletier Y., Dy M., Brousse N.et al. TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells. J. Immunol. 162:1999;4567-4575.
75. Salio M., Cella M., Suter M., Lanzavecchia A. Inhibition of dendritic cell maturation by herpes simplex virus. Eur. J. Immunol. 29:1999;3245-3253.
76. Andrews D.M., Andoniou C.E., Granucci F., Ricciardi-Castagnoli P., Degli-Esposti M.A. Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. Nat. Immunol. 2:2001;1077-1084.
77. Urban B.C., Ferguson D.J., Pain A., Willcox N., Plebanski M., Austyn J.M.et al. Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells. Nature. 400:1999;73-77.