Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS

Journal of Leukocyte Biology

Volumn 73, Issue 5, 2003, Pages 584-590

  Giunti, Debora ^a   Borsellino, Giovanna ^b   Benelli, Roberto ^c   Marchese, Monica ^a   Capello, Elisabetta ^a   Valle, Maria Teresa ^c   Pedemonte, Enrico ^a   Noonan, Douglas ^c   Albini, Adriana ^c   Bernardi, Giorgio ^d   Mancardi, Giovanni Luigi ^a   Battistini, Luca ^b   Uccelli, Antonio ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Cell trafficking; Chemokines; MS; Neuroimmunology; T lymphocytes

Indexed keywords

ANTIGEN; CD27 ANTIGEN; CD45 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCL19; CHEMOKINE RECEPTOR CCL5; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCL10; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON; UNCLASSIFIED DRUG; ALPHA CHEMOKINE; BETA CHEMOKINE; CC CHEMOKINE RECEPTOR 7; CXC CHEMOKINE IP 10; CXC CHEMOKINE IP-10; CXC CHEMOKINE RECEPTOR 3; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; BLOOD; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL POLARITY; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FUNCTIONAL ASSESSMENT; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; LYMPHOCYTE CLONE; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL; ADULT; AGED; BIOSYNTHESIS; CELL MOTION; DRUG EFFECT; ENCEPHALITIS; FEMALE; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; LYME DISEASE; LYMPHOCYTE ACTIVATION; MALE; MENINGITIS; MIDDLE AGED; NEUTROPHIL CHEMOTAXIS; POLYRADICULONEUROPATHY; SECRETION; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD27; ANTIGENS, CD45; CELL DIFFERENTIATION; CELL MOVEMENT; CHEMOKINES, CC; CHEMOKINES, CXC; CHEMOTAXIS, LEUKOCYTE; ENCEPHALITIS; FEMALE; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTERFERON TYPE II; LYME NEUROBORRELIOSIS; LYMPHOCYTE ACTIVATION; MALE; MENINGITIS; MIDDLE AGED; MULTIPLE SCLEROSIS; POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE; T-LYMPHOCYTE SUBSETS; TH1 CELLS;

EID: 0037824666     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1202598     Document Type: Article

References (28)

1. Butcher, E. C., Picker, L. J. (1996) Lymphocyte homing and homeostasis. Science 272, 60-66.
2. Mackay, C. R. (1993) Homing of naive, memory and effector lymphocytes. Curr. Opin. Immunol. 5, 423-427.
3. Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B., Mackay, C. R. (1998) The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J. Clin. Invest. 101, 746-754.
4. Sallusto, F., Lenig, D., Forster, R., Lipp, M., Lanzavecchia, A. (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712.
5. Campbell, J. J., Murphy, K. E., Kunkel, E. J., Brightling, C. E., Soler, D., Shen, Z., Boisvert, J., Greenberg, H. B., Vierra, M. A., Goodman, S. B., Genovese, M. C., Wardlaw, A. J., Butcher, E. C., Wu, L. (2001) CCR7 expression and memory T cell diversity in humans. J. Immunol. 166, 877-884.
6. Lens, S. M., Tesselaar, K., van Oers, M. H., van Lier, R. A. (1998) Control of lymphocyte function through CD27-CD70 interactions. Semin. Immunol. 10, 491-499.
7. Baars, P. A., Maurice, M. M., Rep, M., Hooibrink, B., van Lier, R. A. (1995) Heterogeneity of the circulating human CD4+ T cell population. Further evidence that the CD4+CD45RA-CD27- T cell subset contains specialized primed T cells. J. Immunol. 154, 17-25.
8. Chen, B. P., Kuziel, W. A., Lane, T. E. (2001) Lack of CCR2 results in increased mortality and impaired leukocyte activation and trafficking following infection of the central nervous system with a neurotropic coronavirus. J. Immunol. 167, 4585-4592.
9. Huang, D., Han, Y., Rani, M. R., Glabinski, A., Trebst, C., Sorensen, T., Tani, M., Wang, J., Chien, P., O'Bryan, S., Bielecki, B., Zhou, Z. L., Majumder, S., Ransohoff, R. M. (2000) Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation. Immunol. Rev. 177, 52-67.
10. Alt, C., Laschinger, M. E. B., Engelhardt, B. (2002) Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in C-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 32, 2133-2144.
11. Columba-Cabezas, S., Serafini, B., Ambrosini, E., Aloisi, F. (2003) Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: implications for the maintenance of chronic neuroinflammation. Brain Pathol. 13, 38-51.
12. McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H. P., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., Sandberg-Wollheim, M., Sibley, W., Thompson, A., van den, N. S., Weinshenker, B. Y., Wolinsky, J. S. (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann. Neurol. 50, 121-127.
13. Meyer, A. L., Trollmo, C., Crawford, F., Marrack, P., Steere, A. C., Huber, B. T., Kappler, J., Hafler, D. A. (2000) Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proc. Natl. Acad. Sci. USA 97, 11433-11438.
14. Sallusto, F., Mackay, C. R., Lanzavecchia, A. (2000) The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol. 18, 593-620.
15. Simpson, J., Rezaie, P., Newcombe, J., Cuzner, M. L., Male, D., Woodroofe, M. N. (2000) Expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue. J. Neuroimmunol. 108, 192-200.
16. Balashov, K. E., Rottman, J. B., Weiner, H. L., Hancock, W. W. (1999) CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. Proc. Natl. Acad. Sci. USA 96, 6873-6878.
17. Liu, M. T., Chen, B. P., Oertel, P., Buchmeier, M. J., Armstrong, D., Hamilton, T. A., Lane, T. E. (2000) The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease. J. Immunol. 165, 2327-2330.
18. Pashenkov, M., Teleshova, N., Kouwenhoven, M., Smirnova, T., Jin, Y. P., Kostulas, V., Huang, Y. M., Pinegin, B., Boiko, A., Link, H. (2002) Recruitment of dendritic cells to the cerebrospinal fluid in bacterial neuroinfections. J. Neuroimmunol. 122, 106-116.
19. Misu, T., Onodera, H., Fujihara, K., Matsushima, K., Yoshie, O., Okita, N., Takase, S., Itoyama, Y. (2001) Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling. J. Neuroimmunol. 114, 207-212.
20. Sorensen, T. L., Tani, M., Jensen, J., Pierce, V., Lucchinetti, C., Folcik, V. A., Qin, S., Rottman, J., Sellebjerg, F., Strieter, R. M., Frederiksen, J. L., Ransohoff, R. M. (1999) Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J. Clin. Invest. 103, 807-815.
21. Kim, C. H., Rott, L., Kunkel, E. J., Genovese, M. C., Andrew, D. P., Wu, L., Butcher, E. C. (2001) Rules of chemokine receptor association with T cell polarization in vivo. J. Clin. Invest. 108, 1331-1339.
22. Geginat, J., Sallusto, F., Lanzavecchia, A. (2001) Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells. J. Exp. Med. 194, 1711-1719.
23. Fukada, K., Sobao, Y., Tomiyama, H., Oka, S., Takiguchi, M. (2002) Functional Expression of the Chemokine Receptor CCR5 on Virus Epitope-Specific Memory and Effector CD8+ T Cells. J. Immunol. 168, 2225-2232.
24. Franciotta, D., Martino, G., Zardini, E., Furlan, R., Bergamaschi, R., Andreoni, L., Cosi, V. (2001) Serum and CSF levels of MCP-1 and IP-10 in multiple sclerosis patients with acute and stable disease and undergoing immunomodulatory therapies. J. Neuroimmunol. 115, 192-198.
25. Sorensen, T. L., Sellebjerg, F., Jensen, C. V., Strieter, R. M., Ransohoff, R. M. (2001) Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis. Eur. J. Neurol. 8, 665-672.
26. Yoshida, R., Nagira, M., Imai, T., Baba, M., Takagi, S., Tabira, Y., Akagi, J., Nomiyama, H., Yoshie, O. (1998) EBII-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly upregulate CCR7 and efficiently migrate toward ELC. Int. Immunol. 10, 901-910.
27. Luther, S. A., Bidgol, A., Hargreaves, D. C., Schmidt, A., Xu, Y., Paniyadi, J., Matloubian, M., Cyster, J. G. (2002) Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J. Immunol. 169, 424-433.
28. Colombo, M., Dono, M., Gazzola, P., Roncella, S., Valetto, A., Chiorazzi, N., Mancardi, G. L., Ferrarini, M. (2000) Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients. J. Immunol. 164, 2782-2789.