Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis

Cancer Biology and Therapy

Volumn 4, Issue 4, 2005, Pages 459-467

  Nutt, Leta K ^a   Gogvadze, Vladimir ^a   Uthaisang, Wanlaya ^a   Mirnikjoo, Banafsheh ^b   McConkey, David J ^b   Orrenius, Sten ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Calcium; Caspase; MEFs; Mitochondrial permeability transition; Reactive oxygen species

Indexed keywords

ARSENIC TRIOXIDE; CASPASE; CYTOCHROME C; PROTEIN BAK; PROTEIN BAX; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL IMMORTALIZATION; DRUG EFFECT; ENZYME ACTIVATION; LIVER MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; RESPIRATORY CHAIN;

ANIMALS; APOPTOSIS; ARSENICALS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CYTOCHROME C GROUP; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; FIBROBLASTS; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; NECROSIS; OXIDATIVE STRESS; OXIDES; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 23844468272     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: None     Document Type: Article

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