Blockade of Neurotransmission in Drosophila Mushroom Bodies Impairs Odor Attraction, but Not Repulsion

Current Biology

Volumn 13, Issue 21, 2003, Pages 1900-1904

  Wang, Yalin ^a   Chiang, Ann Shyn ^b   Xia, Shouzhen ^a   Kitamoto, Toshi ^c   Tully, Tim ^a   Zhong, Yi ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BASIDIOMYCOTA; HEXAPODA; MAMMALIA; VERTEBRATA;

EID: 0242318317     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2003.10.003     Document Type: Article

References (27)

1. Livingstone, M., and Hubel, D. (1988). Segregation of form, color, movement, and depth: anatomy, physiology, and perception. Science 240, 740-749.
2. Zeki, S., and Shipp, S. (1988). The functional logic of cortical connections. Nature 335, 311-317.
3. Shipley, M.T., and Ennis, M. (1996). Functional organization of olfactory system. J. Neurobiol. 30, 123-176.
4. Hildebrand, J.G., and Shepherd, G.M. (1997). Mechanisms of olfactory discrimination: converging evidence for common principles across phyla. Annu. Rev. Neurosci. 20, 595-631.
5. Korsching, S. (2002). Olfactory maps and odor images. Curr. Opin. Neurobiol. 12, 387-392.
6. Strausfeld, N.J., Hansen, L., Li, Y., Gomez, R.S., and Ito, K. (1998). Evolution, discovery, and interpretations of arthropod mushroom bodies. Learn. Mem. 5, 11-37.
7. Stocker, R.F., Lienhard, M.C., Borst, A., and Fischbach, K.F. (1990). Neuronal architecture of the antennal lobe in Drosophila melanogaster. Cell Tissue Res. 262, 9-34.
8. Stocker, R.F. (1994). The organization of the chemosensory system in Drosophila melanogaster: a review. Cell Tissue Res. 275, 3-26.
9. Davis, R.L. (1996). Physiology and biochemistry of Drosophila learning mutants. Physiol. Rev. 76, 299-317.
10. Dubnau, J., Grady, L., Kitamoto, T., and Tully, T. (2001). Disruption of neurotransmission in Drosophila mushroom body blocks retrieval but not acquisition of memory. Nature 411, 476-480.
11. McGuire, S.E., Le, P.T., and Davis, R.L. (2001). The role of Drosophila mushroom body signaling in olfactory memory. Science 293, 1330-1333.
12. de Belle, J.S., and Heisenberg, M. (1994). Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies. Science 263, 692-695.
13. Connolly, J.B., Roberts, I.J., Armstrong, J.D., Kaiser, K., Forte, M., Tully, T., and O'Kane, C.J. (1996). Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies. Science 274, 2104-2107.
14. Heimbeck, G., Bugnon, V., Gendre, N., Keller, A., and Stocker, R.F. (2001). A central neural circuit for experience-independent olfactory and courtship behavior in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 98, 15336-15341.
15. Kitamoto, T. (2001). Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons. J. Neurobiol. 47, 81-92.
16. Chen, M.S., Obar, R.A., Schroeder, C.C., Austin, T.W., Poodry, C.A., Wadsworth, S.C., and Vallee, R.B. (1991). Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis. Nature 351, 583-586.
17. Brand, A.H., and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
18. Zars, T., Fischer, M., Schulz, R., and Heisenberg, M. (2000). Localization of a short-term memory in Drosophila. Science 288, 672-675.
19. Ayyub, C., Paranjape, J., Rodrigues, V., and Siddiqi, O. (1990). Genetics of olfactory behavior in Drosophila melanogaster. J. Neurogenet. 6, 243-262.
20. Wang, Y., Wright, N.J., Guo, H., Xie, Z., Svoboda, K., Malinow, R., Smith, D.P., and Zhong, Y. (2001). Genetic manipulation of the odor-evoked distributed neural activity in the Drosophila mushroom body. Neuron 29, 267-276.
21. Devaud, J.M., Keane, J., and Ferrus, A. (2003). Blocking sensory inputs to identified antennal glomeruli selectively modifies odorant perception in Drosophila. J. Neurobiol. 56, 1-12.
22. de Belle, J.S., and Heisenberg, M. (1996). Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm). Proc. Natl. Acad. Sci. USA 93, 9875-9880.
23. Troemel, E.R., Kimmel, B.E., and Bargmann, C.I. (1997). Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans. Cell 91, 161-169.
24. Zald, D.H., and Pardo, J.V. (1997). Emotion, olfaction, and the human amygdala: amygdala activation during aversive olfactory stimulation. Proc. Natl. Acad. Sci. USA 94, 4119-4124.
25. Gottfried, J.A., Deichmann, R., Winston, J.S., and Dolan, R.J. (2002). Functional heterogeneity in human olfactory cortex: an event-related functional magnetic resonance imaging study. J. Neurosci. 22, 10819-10828.
26. Schreiner, C.E., Read, H.L., and Sutter, M.L. (2000). Modular organization of frequency integration in primary auditory cortex. Annu. Rev. Neurosci. 23, 501-529.
27. Tully, T., and Quinn, W.G. (1985). Classical conditioning and retention in normal and mutant Drosophila melanogaster. J. Comp. Physiol. [A] 157, 263-277.