Fatty acids and beta-cell function

Diabetologia

Volumn 40, Issue SUPPL. 3, 1997, Pages

  Bjorklund A ^a   Yaney, G ^b   McGarry, J D ^c,e   Weir, G ^d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b BOSTON MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d JOSLIN DIABETES CENTER   (United States)

^e UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; CARNITINE PALMITOYLTRANSFERASE; CYCLIC AMP; FATTY ACID; GLUCOSE; INSULIN; PHOSPHOTRANSFERASE; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNITY; CONFERENCE PAPER; FATTY ACID SYNTHESIS; GENE CONTROL; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ACYL COENZYME A; ANIMALS; FATTY ACIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISLETS OF LANGERHANS; RATS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 0030805359     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051392     Document Type: Conference Paper

References (12)

1. Civelek VN, Deeney JT, Kubik K, Schultz, V, Tornheim K, Corkey BE (1996) Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic β-cells (HIT). Biochem J 315: 1015-1019
2. Prentki M, Corkey BE (1996) Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45: 273-283
3. Cunningham BA, Deeney JT, Bliss CR, Corkey BE, Tornheim K (1996) Glucose-induced oscillatory insulin secretion in perfused rat pancreatic islets and clonal β-cells (HIT). Am J Physiol 271:E702-E710
4. Larsson O, Deeney JT, Branstrom R, Berggren P-O, Corkey BE (1996) Activation of the ATP-sensitive K + channel by long chain acyl-CoA. A role for modulation of pancreatic β-cell glucose sensitivity. J Biol Chem 271: 10623-10626
5. Prentki M (1996) New insights into pancreatic β-cell metabolic signaling in insulin secretion. Eur J Endocrinology 134: 272-286
6. Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M (1997) Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic β-cell line INS-1. Diabetes 46: 393-400
7. Assimacopoulos-Jeannet F, Thumelin S, Roche E et al. (1997) Fatty acids rapidly induce the carnitine palmitoyl-transferase I gene in the pancreatic β-cell line INS-1. J Biol Chem 272: 1659-1664
8. Stein DT, Esser V, Stevenson B et al. (1996) Essentiality of circulating fatty acids for glucose- stimulated insulin secretion in the fasted rat. J Clin Invest 97: 2728-2735
9. Stein DT, Stevenson BE, Chester MW et al. (1997) The insulinotropic potency of fatty acids is profoundly influenced by their chain length and degree of saturation. J Clin Invest 100: 398-403
10. Sako Y, Grill V (1990) A 48 h lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127: 1580-1589
11. Zhou Y-P, Grill V (1994) Long term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93: 870-876
12. Zhou Y-P, Grill V (1996) A fatty acid induced decrease in pyruvate dehydrogenase activity is an important determinant of β-cell dysfunction in the obese db/db mouse. Diabetes 45: 580-586