Novel 17β-substituted conformationally constrained neurosteroids that modulate GABAA receptors

Journal of Medicinal Chemistry

Volumn 48, Issue 16, 2005, Pages 5203-5214

  Souli, Charikleia ^a   Avlonitis, Nicolaos ^a   Calogeropoulou, Theodora ^a   Tsotinis, Andrew ^b   Maksay, Gábor ^c   Bíró, Tímea ^c   Politi, Aggeliki ^a   Mavromoustakos, Thomas ^a   Makriyannis, Alexandras ^d   Reis, Heribert ^a   Papadopoulos, Manthos ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHOXY 1 [3ALPHA (TERT BUTYLDIPHENYLSILYLOXY) 5ALPHA ANDROSTANE 17BETA YL] 2 PROPYNE; 17BETA (1 HYDROXY 2 PROPYNYL) 5ALPHA ANDROSTAN 3 OL; 17BETA (1 HYDROXY 2,3 BUTADIENYL) 5ALPHA ANDROSTAN 3 OL; 17BETA (1 METHOXY 2 PROPYNYL) 5ALPHA ANDROSTAN 3 OL; 17BETA (2 BROMOETHYNYL) 5ALPHA ANDROSTANE 3ALPHA OL; 17BETA (3 HYDROXY 1 BUTYNYL) 5ALPHA ANDROSTANE 3ALPHA OL; 17BETA (3 OXO 1 PROPYNYL) 5ALPHA ANDROSTANE 3ALPHA OL; 17BETA [1 HYDROXY 3 (4 METHOXYPHENYL) 2 PROPYNYL] 5ALPHA ANDROSTANE 3ALPHA OL; 17BETA [2 (4 TOLYL)ETHYNYL] 5ALPHA ANDROSTANE 3ALPHA OL; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4' ETHYNYL 4 N PROPYL BICYCLOORTHOBENZOATE; BENZOIC ACID DERIVATIVE; IONOTROPIC RECEPTOR; NEUROSTEROID; PRASTERONE SULFATE; PREGNENOLONE SULFATE; TETRAHYDROCORTISOL; UNCLASSIFIED DRUG; 17 (1 HYDROXY 2,3 BUTADIENYL)ANDROSTAN 3 OL; 17-(1-HYDROXY-2,3-BUTADIENYL)ANDROSTAN-3-OL; ANDROSTANE DERIVATIVE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; PROTEIN SUBUNIT;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN SYNAPTOSOME; CEREBELLUM; CHEMICAL BOND; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECT; IN VITRO STUDY; METABOLISM; SYNAPTOSOME; SYNTHESIS; WISTAR RAT;

ALLOSTERIC SITE; ANDROSTANOLS; ANIMALS; CEREBELLUM; GABA MODULATORS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES;

EID: 23444457965     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050271q     Document Type: Article

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