Neurosteroid Analogues. 9. Conformationally Constrained Pregnanes: Structure-Activity Studies of 13,24-Cyclo-18,21-dinorcholane Analogues of the GABA Modulatory and Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one

Journal of Medicinal Chemistry

Volumn 46, Issue 25, 2003, Pages 5334-5348

  Jiang, Xin ^a   Manion, Brad D ^a   Benz, Ann ^a   Rath, Nigam P ^b   Evers, Alex S ^a   Zorumski, Charles F ^a   Mennerick, Steven ^a   Covey, Douglas F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSOURI ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

13,24 CYCLO 18,21 DINORCHOLANE DERIVATIVE; 3 HYDROXYPREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ACETIC ACID DERIVATIVE; ANESTHETIC AGENT; CARBONYL DERIVATIVE; KETONE; NEUROSTEROID; PREGNANE DERIVATIVE; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING ASSAY; BIOASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; FEMALE; GABAERGIC TRANSMISSION; HYDROGEN BOND; NEUROPHARMACOLOGY; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ANESTHETICS; ANIMALS; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; ELECTROPHYSIOLOGY; FEMALE; GABA MODULATORS; LARVA; MODELS, MOLECULAR; NORSTEROIDS; OOCYTES; PATCH-CLAMP TECHNIQUES; PREGNANOLONE; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0344118747     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030302m     Document Type: Article

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