Conformationally constrained anesthetic steroids that modulate GABA(A) receptors

Journal of Medicinal Chemistry

Volumn 43, Issue 22, 2000, Pages 4118-4125

  Anderson, A ^a   Boyd, A C ^a   Clark, J K ^a   Fielding, L ^a   Gemmell, D K ^a   Hamilton, N M ^a   Maidment, M S ^a   May, V ^a   McGuire, R ^a   McPhail, P ^a   Sansbury, F H ^a   Sundaram, H ^a   Taylor, R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3ALPHA,5ALPHA) 3 HYDROXYANDROSTAN 16 ONE; (3ALPHA,5ALPHA,13ALPHA,17ALPHA) 3 HYDROXYANDROSTANE 17 CARBONITRILE; (3ALPHA,5ALPHA,16ALPHA,17ALPHA) 16,17 EPOXYANDROSTAN 3 OL; (3ALPHA,5ALPHA,16BETA,17BETA) 16,17 4H DIHYDRO 3 HYDROXYANDROST 16 ENO[17,16 B]OXETANE; (3ALPHA,5ALPHA,16BETA,17BETA) 16,17 EPOXYANDROSTAN 3 OL; (3ALPHA,5ALPHA,17ALPHA) 17,21 EPOXYPREGNAN 3 OL; (3ALPHA,5ALPHA,17BETA) 17 METHOXYANDROSTAN 3 OL; (3ALPHA,5ALPHA,17BETA)SPIRO(ANDROSTAN 17,2' OXIRAN) 3 OL; (3ALPHA,5BETA,16BETA,17BETA) 16,17 EPOXYANDROSTAN 3 OL; (3ALPHA,5BETA,17BETA)SPIRO(ANDROSTAN 17,2' OXIRAN) 3 OL; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ANESTHETIC AGENT; UNCLASSIFIED DRUG;

ANESTHESIA; ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; HYDROGEN BOND; MOUSE; NONHUMAN;

ANDROSTANOLS; ANESTHETICS; ANIMALS; BRAIN; GABA MODULATORS; HYDROGEN BONDING; INJECTIONS, INTRAVENOUS; MICE; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034597545     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000977e     Document Type: Article

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