Neurosteroid analogues. 6. The synthesis and GABA(A) receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3α,5β)-3-hydroxypregnan-20-one sulfate

Journal of Medicinal Chemistry

Volumn 41, Issue 14, 1998, Pages 2604-2613

  Nilsson, Kent R ^a   Zorumski, Charles F ^a   Covey, Douglas F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (SULFOOXY)ANDROST 5 EN 17 ONE AMMONIUM; 3 (SULFOOXY)PREGN 5 EN 20 ONE AMMONIUM; 3 (SULFOOXY)PREGNAN 20 ONE AMMONIUM; 3 HYDROXYPREGNAN 20 ONE SULFATE; 4 AMINOBUTYRIC ACID A RECEPTOR; NEUROSTEROID; PRASTERONE SULFATE; PREGNENOLONE SULFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENANTIOMER; GABAERGIC SYSTEM; HIPPOCAMPUS; NONHUMAN; RAT; STEROIDOGENESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELLS, CULTURED; DEHYDROEPIANDROSTERONE SULFATE; GABA MODULATORS; HIPPOCAMPUS; NEURONS; PATCH-CLAMP TECHNIQUES; PREGNANOLONE; PREGNENOLONE; RATS; RECEPTORS, GABA-A; STEREOISOMERISM;

EID: 0032474840     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980148h     Document Type: Article

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