Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 9, 1999, Pages 1299-1304

  Bin, Tao ^a   Huang, Tien L ^a   Sharma, Terre A ^b   Reynolds, Ian J ^b   Donkor, Isaac O ^c  

^a XAVIER UNIVERSITY OF LOUISIANA   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDINE DERIVATIVE; CALCIUM; DIZOCILPINE; IMIDAZOLINE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; NEUROPROTECTION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAMIDINES; BENZIMIDAZOLES; CALCIUM; CELL SURVIVAL; GLUTAMIC ACID; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PROSENCEPHALON; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0033519177     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00184-5     Document Type: Article

References (19)

1. Morris, R. G. M.; Anderson, E.; Lynch, G. S.; Baudry, M. Nature (London) 1986, 319, 774.
2. Dingledine, R.; McBain, C. J.; McNamara, O. Trends Pharmacol. Sci. 1991, 11, 334.
3. Navia, B. A.; Jordan, B. D.; Price, R. W. Ann. Neurol. 1986, 19, 517.
4. Gabuzda, D. H.; Hirch, M. S.; Ann. Int. Med. 1987, 107, 383.
5. Price, R. W.; Brew, B.; Sidtis, J.; Rosenblum, M.; Scheck, A. C.; Clearry. P. Science 1988, 239, 586.
6. Wiley, C. A.; Masliah, E.; Morey, M.; Lemere, C.; DeTeresa, R.; Grafe, M.; Hansen, L.; Terry, R. Ann. Neurol. 1991, 29, 651.
7. Ketzler, S.; Weis, S.; Haug, H.; Budka, H. Acta Neuropathol. 1990, 80, 92.
8. Lipton, S. A.; Sucher, N. J.; Kraiser, P. K.; Dreyer, E. B. Neuron 1991, 7, 111.
9. Reynolds, I. J. Mol. Pharmacol. 1992, 41, 989.
10. Reynolds, I. J.; Rothermund, K.; Rajdev, S. Bioorg. Med. Chem. Lett. 1993, 3, 85.
11. Benveniste, M.; Mayer, M. L. J. Physiol. (London) 1993, 464, 131.
12. Marvizon, J. C.; Baudry, M. Eur. J. Pharmacol. 1994, 269, 165.
13. Reynolds, I. J.; Aizenman, E. J. Neurosci. 1992, 12, 970.
14. Reynolds, I. J.; Zeleski, D. M.; Rothermund, K. D.; Hartnett, K. A.; Tidwell, R. R.; Aizenman, E. Eur. J. Pharmacol. 1993, 244, 175.
15. Donkor, I. O.; Berger, M. L. Bioorg. Med. Chem. Lett. 1997, 7, 1455.
16. Huang, T. L.; Zhang, Q.; White, A. T.; Queener, S. F.; Bartlett, M. S.; Smith, J. W.; Donkor, I. O. Bioorg. Med. Chem. Lett. 1996, 6, 2087.
17. Tao, B.; Huang, T. L.; Zhang, Q.; Jackson, L.; Queener, S. F.; Donkor, I. O. Eur. J. Med. Chem., in press.
18. Reynolds, I. J. J. Pharmacol. Exp. Ther. 1990, 255, 1001.
19. Reynolds, I. J.; Miller, R. J. Mol. Pharmacol. 1988, 33, 581.