A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 2, 1997, Pages 379-384

  Cushion, Melanie T ^a   Chen, Franklin ^a   Kloepfer, Natalie ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 (4 CYCLOHEPTYLPHENYL)PROPYL] 3 HYDROXY 1,4 NAPHTHOQUINONE; 2,4 DINITROPHENOL; ACEDAPSONE; ACRIDINE; ACRIFLAVINE; ADENOSINE TRIPHOSPHATE; AMSACRINE; ANTIMYCIN A1; ANTIPROTOZOAL AGENT; CAMPTOTHECIN; CHLORPROMAZINE; CHOLERA TOXIN; COTRIMOXAZOLE; DAPSONE; DIMINAZENE; ETOPOSIDE; IMIPRAMINE; MENOCTONE; NSC 108700; NSC 112922; NSC 117252; NSC 92074; NSC 92203; OLIGOMYCIN; PENTAMIDINE; PERTUSSIS TOXIN; PHENANTHRIDINE DERIVATIVE; POTASSIUM CYANIDE; QUINONE DERIVATIVE; SULFADIAZINE; SULFADOXINE; SULFAMETHOXAZOLE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; BIOLUMINESCENCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; NONHUMAN; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0031039940     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.2.379     Document Type: Article

References (46)

1. Allegra, C. J., J. A. Kovacs, J. C. Drake, J. C. Swan, B. A. Chabner, and H. Masur. 1987. Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent. J. Exp. Med. 165: 926-931.
2. Armstrong, M. Y. K., and M. T. Cushion. 1994. In vitro cultivation, p. 3-24. In P. D. Walzer (ed.), Pneumocystis carinii pneumonia, 2nd ed. Marcel Dekker, Inc., New York, N.Y.
3. Banerji, S., A. E. Wakefield, A. G. Allen, D. J. Maskell, S. E. Peters, and J. M. Hopkin. 1993. The cloning and characterization of the arom gene of Pneumocystis carinii. J. Gen. Microbiol. 139:2901-2914.
4. Bartlett, M. S., R. Eicholtz, and J. W. Smith. 1985. Antimicrobial susceptibility of Pneumocystis carinii in culture. Diagn. Microbiol. Infect. Dis. 3:381-387.
5. Bartlett, M. S., J. J. Marr, S. F. Queener, R. S. Klein, and J. W. Smith. 1986. Activity of inosine analogs against Pneumocystis carinii in culture. Antimicrob. Agents Chemother. 30:181-183.
6. Bartlett, M. S., S. F. Queener, R. R. Tidwell, W. K. Milhous, J. D. Berman, W. Y. Ellis, and J. W. Smith. 1991. 8-Aminoquinolones from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models. Antimicrob. Agents Chemother. 35:277-282.
7. Bartlett, M. S., T. D. Edlind, C. H. Lee, R. Dean, S. F. Queener, M. M. Shaw, and J. W. Smith. 1994. Albendazole inhibits Pneumocystis carinii proliferation in inoculated immunosuppressed mice. Antimicrob. Agents Chemother. 38:1834-1837.
8. Boylan, C. J., and W. L. Current. 1992. Improved rat model of Pneumocystis carinii pneumonia: induced laboratory infections in Pneumocystis-free animals. Infect. Immun. 60:1589-1597.
9. Brun-Pascaud, M., M. Fay, M. Zhong, J. Bauchet, A. Dux-Guyot, and J.-J. Pocidalo. 1992. Use of fluoroquinolones for prophylaxis of murine Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 36:470-472.
10. Calabrese, E. J. 1991. Principles of animal extrapolation, p. 437. Lewis Publishers, Inc., Chelsea, Mich.
11. Chen, F., and M. T. Cushion. 1994. Use of an ATP bioluminescent assay to evaluate viability of Pneumocystis carinii from rats. J. Clin. Microbiol. 32: 2791-2800.
12. Clarkson, A. B., Jr., D. E. Williams, and C. Rosenberg. 1988. Efficacy of DL-α-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 32:1158-1163.
13. Clarkson, A. B., Jr., and F. H. Brohn. 1976. Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism. Science 194: 204-206.
14. Clarkson, A. B., Jr., M. Sarić, and R. W. Grady. 1990. Deferoxamine and eflornithine (DL-α-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia. Antimicrob. Agents Chemother. 34:1833-1835.
15. Comley, J. C. W., R. J. Mullin, L. A. Wolfe, M. H. Hanlon, and R. Ferone. 1991. Microculture screening assay for primary in vitro evaluation of drugs against Pneumocystis carinii. Antimicrob. Agents Chemother. 35:1965-1974.
16. Comotois, R., J. Pouliot, B. Vinet, A. Gervais, and C. Lemieux. 1992. Higher pentamidine levels in AIDS patients with hypoglycemia and azotemia during treatment of Pneumocystis carinii pneumonia. Am. Rev. Respir. Dis. 146: 740-744.
17. Cushion, M. T., J. J. Ruffolo, M. J. Linke, and P. D. Walzer. 1985. Pneumocystis carinii: growth variables and estimates in A549 and WI38 VA 13 human cell lines. Exp. Parasitol. 60:43-54.
18. Cushion, M. T., D. Stanforth, M. J. Linke, and P. D. Walzer. 1985. Method of testing the susceptibility of Pneumocystis carinii to antimicrobial agents in vitro. Antimicrob. Agents Chemother. 28:769-801.
19. Cushion, M. T. 1988. In vitro studies of Pneumocystis carinii. J. Protozool. 36:45-52.
20. Cushion, M. T., and D. Ebbets. 1990. Growth and metabolism of Pneumocystis carinii in axenic culture. J. Clin. Microbiol. 28:1385-1394.
21. Cushion, M. T., M. Kaselis, S. L. Stringer, and J. R. Stringer. 1993. Genetic stability and diversity of Pneumocystis carinii infecting rat colonies. Infect Immun. 61:4801-4813.
22. Cushion, M. T., and S. Orr. Kinetics of two genetically distinct Pneumocystis populations in rat colonies. J. Eukaryot. Microbiol. 43:465.
23. Desjardins, R. E., R. A. Casero, G. P. Willet, G. E. Childs, and C. J. Canfield. 1980. Trypanosoma rhodesiense: semiautomated microtesting for quantitation of antitrypanosomal activity in vitro. Exp. Parasitol. 50:260-271.
24. Dohn, M. T., and P. T. Frame. 1994. Clinical manifestations in adults, p. 331-360. In P. D. Walzer (ed.), Pneumocystis carinii pneumonia, 2nd ed. Marcel Dekker, Inc., New York, N.Y.
25. Dykstra, C. C., and R. R. Tidwell. 1991. Inhibition of topoisomerases from Pneumocystis carinii by aromatic dicationic molecules. J. Protozool. 6:78-81s.
26. Feinberg, J. 1995. Critical look at new therapies, p. 487-503. In F. R. Sattler and P. D. Walzer (ed.), Bailliere's clinical infectious diseases, Pneumocystis carinii. Bailliere Tindall, Philadelphia, Pa.
27. Ferguson, L. R., and R. J. Sundberg. 1991. Petite mutagenesis in Saccharomyces cerevisiae by a series of bis-cationic trypanocidal drugs. Antimicrob. Agents. Chemother. 35:2318-2321.
28. Fishman, J. A., S. F. Queener, R. S. Roth, and M. S. Bartlett. 1993. Activity of topoisomerase inhibitors against Pneumocystis carinii in vitro and in an inoculated mouse model. Antimicrob. Agents Chemother. 37:1543-1546.
29. Frenkel, J. K., J. T. Good, and J. A. Schultz. 1966. Latent Pneumocystis infection of rats, relapse and chemotherapy. Lab. Invest. 15:1559-1577.
30. Griffiths, D. E., and R. L. Houghton. 1974. Studies on energy-linked reactions: modified mitochondrial ATPase oligomycin-resistant mutants of Saccharomyces cerevisiae. J. Biochem. 46:157-167.
31. Hughes, W. T., and B. L. Smith. 1984. Efficacy of diaminophenylsulfone and other drugs in murine Pneumocystis carinii pneumonitis. Antimicrob. Agents Chemother. 26:436-440.
32. Kaneshiro, E. S., Y.-P. Wu, and M. T. Cushion. 1991. Assays for testing Pneumocystis carinii viability. J. Protozool. 38(Suppl.):85-87.
33. Kuzmits, R., H. Rumpold, M. M. Muller, and G. Schopf. 1986. The use of bioluminescence to evaluate the influence of chemotherapeutic drugs on ATP levels of malignant cell lines. J. Clin. Chem. Clin. Biochem. 24:293-298.
34. The members of the European Concerted Action on Pneumocystis carinii. 1996. In vitro systems in Pneumocystis research. Parasitol. Today 12:245-249.
35. Mordelet-Dambrine, M., C. Daniel, R. Farinotti, G. Urzua, L. Barritault, and G. Huchon. 1992. Influence of Pneumocystis carinii pneumonia on serum and tissue concentrations of pentamidine administered to rats by tracheal injections. Am. Rev. Respir. Dis. 146:735-739.
36. Pesanti, E. L., and C. Cox. 1981. Metabolic and synthetic activities of Pneumocystis carinii in vitro. Infect. Immun. 34:908-914.
37. Pifer, L. L., D. Woods, and W. T. Hughes. 1978. Propagation of Pneumocystis carinii in Vero cell culture. Infect. Immun. 20:66-68.
38. Queener, S. F., J. R. Black, M. S. Bartlett, and J. W. Smith. 1994. Primaquine, other 8-aminoquinolones and clindamycin, p. 585-602. In P. D. Walzer (ed.), Pneumocystis carinii pneumonia, 2nd ed. Marcel Dekker, New York, N.Y.
39. Queener, S. F., M. S. Bartlett, J. D. Richardson, M. M. Durkin, M. A. Jay, and J. W. Smith. 1988. Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo. Antimicrob. Agents Chemother. 32:807-813.
40. Sevin, B. U., Z. L. Peng, J. P. Perras, P. Ganjei, M. Penalver, and H. E. Averette. 1988. Application of an ATP-bioluminescence assay in human tumor chemosensitivity testing. Gynecol. Oncol. 31:191-204.
41. Smaldone, G. C., C. Vinciguerra, and L. Morra. 1991. Urine pentamidine as an indicator of lung pentamidine in patients receiving aerosol therapy. Chest 5:1219-1223.
42. Smith, J. W., and M. S. Bartlett. 1984. In vitro cultivation of Pneumocystis p. 107-137. In L. Young (ed.), Pneumocystis carinii pneumonia. Marcel Dekker, Inc., New York, N.Y.
43. Smith, J. W., M. S. Bartlett, and S. F. Queener. 1994. Development of models and their use to discover new drugs for therapy and prophylaxis of Pneumocystis carinii pneumonia, p. 487-509. In P. D. Walzer (ed.), Pneumocystis carinii pneumonia, 2nd ed. Marcel Dekker, Inc., New York, N.Y.
44. Tegoshi, T. 1988. New system of in vitro cultivation of Pneumocystis carinii without feeder cells. J. Kyoto Prefect. Univ. Med. 97:1473-1482.
45. Walzer, P. D. 1994. Development of new anti-Pneumocystis carinii pneumonia. Cumulative experience at a single institution, p. 511-543. In P. D. Walzer (ed.), Pneumocystis carinii pneumonia, 2nd ed. Marcel Dekker, Inc., New York, N.Y.
46. Walzer, P. D. Unpublished data.