Effects of cationic diamidines on polyamine content and uptake on Leishmania infantum in in vitro cultures

Biochemical Pharmacology

Volumn 52, Issue 6, 1996, Pages 835-841

  Calonge, Mar ^a   Johnson, Raoul ^a   Balaña Fouce, Rafael ^a   Ordóñez, David ^a  

^a UNIVERSITY OF LEÓN   (Spain)

Author keywords

cationic diamidines; DNA binding; Leishmania; polyamines

Indexed keywords

CATION; CGP 33829A; CGP 35753A; CGP 36958A; CGP 39937A; CGP 40215A; DIAMIDINE DERIVATIVE; POLYAMINE; PUTRESCINE; RADIOISOTOPE; SPERMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DRUG MECHANISM; DRUG UPTAKE; LEISHMANIA INFANTUM; NONHUMAN; POLYAMINE METABOLISM; PRIORITY JOURNAL; PROMASTIGOTE; STRUCTURE ACTIVITY RELATION;

EID: 0030603960     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00348-6     Document Type: Article

References (34)

1. 1. Olliaro PL and Bryceson ADM, Practical progress and new drugs for changing patterns of leishmaniasis. Parasitol Today 9: 323-328, 1993.
2. 2. Van-Voorish WC, Therapy and prophylaxis of systemic protozoan infections. Drugs 40: 176-202, 1990.
3. 3. Napier LD and Sen-Gupta PC, The treatment of kala-azar with diamidino-di-phenoxy-pentane. Preliminary observations on the treatment of 32 cases. Indian Med Gaz 78: 177-183, 1943.
4. 4. Sands M, Kron MA and Brown RN, Pentamidine: a review. Rev Infect Dis 7: 625-634, 1985.
5. 5. Anonymous, Pentamidine isethionate approved for Pneumocystis carinii pneumonia. FDA Drug Bul 14: 25-26, 1984.
6. 6. Pearson PD and Hewlett EL, Pentamidine for the treatment of Pneumocystis carinii pneumonia and other protozoan diseases. Ann Intern Med 103: 782-786, 1985.
7. 7. Bell CA, Hall JE, Kyle DE, Grogl M, Ohemeng KA, Allen MA and Tidwell RR, Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis. Antimicrob Agents Chemother 14: 449-461, 1990.
8. 8. Bell CA, Cory M, Fairley TA, Hall JE and Tidwell RR, Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity. Antimicrob Agents Chemother 35: 1099-1107, 1991.
9. 9. Tidwell RR, Jones SK, Geratz JD, Ohemeng KA, Bell CA, Berger BJ and Hall JE, Development of pentamidine analogues as new agents for the treatment of Pneumocystis carinii pneumonia. Ann NY Acad Sci 616: 421-441, 1990.
10. 10. Dykstra CC and Tidwell RR, Inhibition of Topoisomerases from Pneumocystis carinii by aromatic dicationic molecules. J Protocol 38: 78S-81S, 1991.
11. 11. Bacchi CJ, Content, synthesis and functions of polyamines in Trypanosomatids: relationship to chemotherapy. J Protozool 28: 20-27, 1981.
12. 12. Reguera MR, Balaña-Fouce R, Cubría JC, Alvarez-Bujidos ML and Ordóñez D, Fluorinated analogues of L-ornithine are powerful inhibitors of ornithine decarboxylase and cell growth of Leishmania infantum promastigotes. Life Sci 56: 223-230, 1994.
13. 13. Balaña-Fouce R, Garzón MT, Garrido A and Ordóñez D, Inhibition of diamine oxidase and S-adenosyl-L-methionine decarboxylase by diminazene aceturate (Berenil). Biochem Pharmacol 35: 1597-1600, 1986.
14. 14. Bitonti AJ, Dumont JA and McCann PP, Characterization of Trypanosoma brucei brucei S-adenosyl-methionine decarboxylase and its inhibition by berenil, pentamidine and methylglyoxal bis(guanylhydrazone). Biochem J 237: 685-689, 1986.
15. 15. Karvonen E, Kauppinen L, Partanen T and Pössö H, Irreversible inhibition of putrescine stimulated S-adenosyl-L-methionine decarboxylase by berenil and pentamidine. Biochem J 231: 165-169, 1985.
16. 16. Balaña Fouce R, Ordóñez D and Alunda JM, Putrescine transport system in Leishmania infantum promastigotes. Mol Biochem Parasitai 35: 43-50, 1989.
17. 17. Reguera MR, Balaña-Fouce R, Cubría JC, Alvarez-Bujidos ML and Ordóñez D, Putrescine uptake inhibition by aromatic diamidines in Leishmania infantum promastigotes. Biochem Pharmacol 47: 1859-1866, 1994.
18. 18. Scanek J, Caravatti G, Capraro HG, Furet P, Mett H, Schneider P and Regenass U, S-Adenosylmethionine decarboxylase inhibitors: New aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone). J Med Chem 36: 46-54, 1993.
19. 19. Iovannisci DM and Ullman B, High efficiency plating method for Leishmania promastigotes in semi-defined medium or completely defined medium. J Parasitol 60: 633-635, 1983.
20. 20. Double JC and Brown JR, The interaction of aminolkyl/amino anthraquinones with deoxyribonucleic acid. J Pharm Pharmacol 27: 502-507, 1975.
21. 21. Escribano MI and Legaz ME, High-Performance liquid chromatography of the dansyl derivatives of putrescine, spermidine and spermine. Plant Physiol 87: 519-522, 1988.
22. 22. Bradford MM, A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
23. 23. Walzer PD, Kim CK, Foy J, Kinke MJ and Cushion MT, Cationic antitrypansomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia. Antimicrob Agents Chemother 32: 896-905, 1988.
24. 24. Croft SL, Recent developments in the chemotherapy of leishmaniasis. Trends Pharmacol Sci 9: 376-381, 1988.
25. 25. Cubría JC, Balaña-Fouce R, Alvarez-Bujidos ML, Negro A, Ortiz AI and Ordóñez D, Aromatic diamidines are reversible inhibitors of porcine kidney diamine oxidase. Biochem Pharmacol 45: 1355-1357, 1993.
26. 26. Byers TL, Bush TL, McCann PP and Bitonti AJ, Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine. Biochem J 274: 527-533, 1991.
27. 27. Pegg AE and Pösö H, S-Adenosylmethionine decarboxylase (rat liver). Meth Enzymol 94: 234-239, 1983.
28. 28. Tekwani BL, Bacchi CJ, Secrist III JA and Pegg AE, Irreversible inhibition of S-adenosyl-L-metionine decarboxylase of Trypanosoma brucei brucei by S-adenosyl-L-methionine analogues. Biochem Pharmacol 44: 905-911, 1992.
29. 29. Balaña-Fouce R, Escribano MI and Alunda JM, Putrescine uptake regulation in response to alpha-difluoromethylornithine treatment in Leishmania infantum promastigotes. Mol Cell Biochem 107: 127-133, 1991.
30. 30. Quemener V, Blanchard LC, Chamaillard R, Havouis R, Cipolla B and Moulinoux JP, Polyamine deprivation: a new tool in cancer treatment. Anticancer Res 14: 443-448, 1994.
31. 31. Nathan HC, Bacchi CJ, Hutner SH, Rescigno D, McCann PP and Sjoerdsma A, Antagonism by polyamines of the curative effect of α-difluoromethylornithine in Trypanosoma brucei brucei infections. Biochem Pharmac 30: 3010-3013, 1981.
32. 32. Pearl LH, Skelly JV, Hudson BD and Neidle S, The crystal structure of DNA-binding drug Berenil: a molecular modeling of Berenil-DNA complexes. Nucleic Acid Res 15: 3469-3478, 1987.
33. 33. Basu HS and Marton LJ, The interaction of spermine and pentamidine with DNA. Biochem J 244: 243-246, 1987.
34. 34. Basu HS, Schwiertert HCA, Feuerstein BG and Marton LJ, Effect of variation in the structure of spermine on the association with DNA and the induction of DNA conformational changes. Biochem J 269: 329-334, 1990.