C/EBPα inhibits cell growth via direct repression of E2F-DP-mediated transcription

Molecular and Cellular Biology

Volumn 20, Issue 16, 2000, Pages 5986-5997

  Slomiany, B A ^a   D'Arigo, K L ^a   Kelly, M M ^a   Kurtz, D T ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; DIHYDROFOLATE REDUCTASE; TRANSCRIPTION FACTOR E2F; CARRIER PROTEIN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; E2F1 PROTEIN, MOUSE; ISOPROTEIN; NUCLEAR PROTEIN; RETINOBLASTOMA BINDING PROTEIN 1; TFDP1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTOR E2F1;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL CYCLE S PHASE; CELL GROWTH; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; ANIMAL; CELL DIVISION; CELL LINE; GENETICS;

ANIMALS; CARRIER PROTEINS; CCAAT-ENHANCER-BINDING PROTEINS; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; MICE; NUCLEAR PROTEINS; PROTEIN ISOFORMS; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033624014     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.16.5986-5997.2000     Document Type: Article

References (52)

1. Nucleotide sequences required for the regulation of a rat alpha2u-globulin gene by glucocorticoids
2. Identification of nuclear proteins that bind to the glucocorticoid regulatory region of a rat alpha 2u-globulin gene
3. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/ enhancer binding protein
4. Reporter constructs with low background activity utilizing the CAT gene
5. Suppression of tumorgenicity of human prostate carcinoma cells by replacing a mutated Rb gene
6. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
7. Glucocorticoids stimulate p21 gene expression by targeting multiple transcriptional elements within a steroid responsive region of the p21(waf1/cip1) promoter in rat hepatoma cells
8. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
9. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
10. Domains A and B in the Rb pocket interact to form a transcriptional repressor motif
11. Role of the CCAAT/enhancer binding protein-α transcription factor in the glucocorticoid stimulation of p21(waf1/cip1) gene promoter activity in growth-arrested rat hepatoma cells
12. C/EBP alpha: A critical regulator of genes governing integrative metabolic processes
13. Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control
14. WAF1 a potential mediator of p53 tumor suppression
15. Retinoblastoma gene product Rb accumulates during myogenic differentiation and is deinduced by the expression of SV40 large T antigen
16. CCAAT/ enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells
17. Context-dependent transcriptional regulation
18. Activation of the murine dihydrofolate reductase promoter by E2F1: A requirement for CBP recruitment
19. MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation
20. Induction patterns of 70 genes during nine days after hepatectomy define the temporal course of liver regeneration
21. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
22. Regulation of cell proliferation by the E2F transcription factors
23. Signaling pathways through which insulin regulates CCAAT/ enhancer binding protein alpha (C/EBPα) phosphorylation and gene expression in 3T3-L1 adipocytes: Correlation with GLUT4 gene expression
24. The retinoblastoma protein: A master regulator of cell cycle, differentiation, and apoptosis
25. Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter
26. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53
27. Hormonal inducibility of rat α(2u) globulin genes in transfected mouse cells
28. Biological role of the CCAAT/enhancer-binding protein family of transcription factors
29. CCAAT/enhancer-binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program
30. p53-Dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
31. The HIP binding site is required for growth regulation of the dihydrofolate reductase promoter
32. Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBPα) gene expression during hepatocyte proliferation in the regenerating liver and in culture
33. Control of pRB phosphorylation
34. CCAAT/ enhancer-binding protein delta regulates mammary epithelial cell G(0) growth arrest and apoptosis
35. The role of C/EBP isoforms in the control of inflammatory and native immunity functions
36. Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes
37. Sequence requirements for secondary glucocorticoid inducibility of rat alpha 2u globulin genes
38. Role of the retinoblastoma protein in the pathogenesis of human cancer
39. Functional and physical associations between NF-kappa B and C/EBP family members: A Rel domain-bZIP interaction
40. CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein
41. CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice
42. Regenerating livers of old rats contain high levels of C/EBPalpha that correlate with altered expression of cell cycle associated proteins
43. C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice
44. The human estrogen receptor has two independent non-acidic transcriptional activation functions
45. CCAAT-enhancer binding proteins: A component of a differentiation switch
46. E2F-mediated growth regulation requires transcription factor cooperation
47. Impaired energy homeostasis in C/EBP alpha knockout mice
48. Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein
49. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity
50. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins
51. Role of pRb-related proteins in simian virus 40 large T-antigen-mediated transformation