E2F-1 and E2F-3 are functionally distinct in their ability to promote myeloid cell cycle progression and block granulocyte differentiation

Cell Growth and Differentiation

Volumn 9, Issue 1, 1998, Pages 59-69

  Strom, David K ^a   Cleveland, John L ^b,c   Chellappan, Srikumar ^d   Nip, John ^a   Hiebert, Scott W ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 3; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F3; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL CYCLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GRANULOCYTE; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

APOPTOSIS; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL LINE; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; E2F2 TRANSCRIPTION FACTOR; E2F3 TRANSCRIPTION FACTOR; E2F4 TRANSCRIPTION FACTOR; E2F5 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTES; HUMANS; INTERLEUKIN-3; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0031975921     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. 1-S-regulatory genes. Mol. Cell. Biol., 15: 4215-4224, 1995.
2. Li, Y., Slansky, J. E., Myers, D. J., Drinkwater, N. R., Kaelin, W. G., and Farnham, P. J. Cloning, chromosomal location, and characterization of mouse E2F1. Mol. Cell. Biol., 14: 1861-1869, 1994.
3. Sala, A., Nicolaides, N. C., Engelhard, A., Bellon, T., Lawe, D. C., Arnold, A., Grana, X., Giordano, A., and Calabretta, B. Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells. Cancer Res., 54: 1402-1406, 1994.
4. Mudrak, I., Ogris, E., Rotheneder, H., and Wintersberger, E. Coordinated transactivation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein. Mol. Cell. Biol., 14: 1886-1892, 1994.
5. Sanchez, I., and Dynlacht, B. D. Transcriptional control of the cell cycle. Curr. Opin. Cell Biol., 8: 318-324, 1996.
6. Beijersbergen, R. L., and Bernards, R. Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins. Biochim. Biophys. Acta, 1287: 103-120, 1996.
7. Meyers, S., and Hiebert, S. W. Direct and indirect alteration of transcriptional regulation in cancer. Grit. Rev. Eukaryotic Gene Expr., 5: 365-383, 1995.
8. Weintraub, S. J., Chow, K. N., Luo, R. X., Zhang, S. H., He, S., and Dean, D. C. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature (Lond.), 375: 812-815, 1995.
9. Chellappan, S., Kraus, V. B., Kroger, B., Munger, K., Howley, P. M., Phelps, W. C., and Nevins, J. R. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. USA, 89: 4549-4553, 1992.
10. Dyson, N., Dembski, M., Fattaey, A., Ngwu, C., Ewen, M., and Helin, K. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J. Virol., 67: 7641-7647, 1993.
11. Chittenden, T., Livingston, D. M., and DeCaprio, J. A. Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol. Cell. Biol., 13: 3975-3983, 1993.
12. Moberg, K., Starz, M. A., and Lees, J. A. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol., 16: 1436-1449, 1996.
13. Ginsberg, D., Vairo, G., Chittenden, T., Xiao, Z. X., Xu, G., Wydner, K. L., DeCaprio, J. A., Lawrence, J. B., and Livingston, D. M. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev., 8: 2665-2679, 1994.
14. Beijersbergen, R. L., Kerkhoven, R. M., Zhu, L., Carlee, L., Voorhoeve, P. M., and Bernards, R. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev., 8: 2680-2690, 1994.
15. Hijmans, E. M., Voorhoeve, P. M., Beijersbergen, R. L., van't Veer, L. J., and Bernards, R. E2F-5, a new E2F family member that interacts with p130 in vivo. Mol. Cell. Biol., 15: 3082-3089, 1995.
16. Mudryj, M., Devoto, S. H., Hiebert, S. W., Hunter, T., Pines, J., and Nevins, J. R. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell, 65: 1243-1253, 1991.
17. Johnson, D. G. Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity. Oncogene, 11: 1685-1692, 1995.
18. Cobrinik, D., Whyte, P., Peeper, D. S., Jacks, T., and Weinberg, R. A. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev., 7: 2392-2404, 1993.
19. Vairo, G., Livingston, D. M., and Ginsberg, D. Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev., 9: 869-881, 1995.
20. Dobrowolski, S. F., Stacey, D. W., Harter, M. L., Stine, J. T., and Hiebert, S. W. An E2F dominant negative mutant blocks E1A-induced cell cycle progression. Oncogene, 9: 2605-2612, 1994.
21. Johnson, D. G., Schwarz, J. K., Cress, W. D., and Nevins, J. R. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (Lond.), 365: 349-352, 1993.
22. INK4A-mediated growth suppression. Mol. Cell. Biol., 16: 1047-1057, 1996.
23. Duronio, R. J., O'Farrell, P. H., Xie, J. E., Brook, A., and Dyson, N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev., 9: 1445-1455, 1995.
24. Hiebert, S. W., Packham, G., Strom, D. K., Haffner, R., Oren, M., Zambetti, G., and Cleveland, J. L. E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis. Mol. Cell. Biol., 15: 6864-6874, 1995.
25. Kowalik, T. F., DeGregori, J., Schwarz, J. K., and Nevins, J. R. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol., 69: 2491-2500, 1995.
26. Qin, X. Q., Livingston, D. M., Kaelin, W. G., Jr., and Adams, P. D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA, 91: 10918-10922, 1994.
27. Shan, B., and Lee, W. H. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol., 14: 8166-8173, 1994.
28. Wu, X., and Levine, A. J. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA, 91: 3602-3606, 1994.
29. Nip. J., Strom, D. K., Fee, B. E., Zambetti, G., Cleveland, J. L., and Hiebert, S. W. E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis. Mol. Cell. Biol., 17: 1049-1056, 1997.
30. Guy, C. T., Zhou, W., Kaufman, S., and Robinson, M. O. E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes. Mol. Cell. Biol., 16: 685-693, 1996.
31. Askew, D. S., Ashmun, R. A., Simmons, B. C., and Cleveland, J. L. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene, 6: 1915-1922, 1991.
32. Hateboer, G., Kerkhoven, R. M., Shvarts, A., Bernards, R., and Beijersbergen, R. L. Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovims transforming proteins. Genes Dev., 10: 2960-2970, 1996.
33. Hofmann, F., Martelli, F., Livingston, D. M., and Wang, Z. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitinproteasome pathway. Genes Dev., 10: 2949-2959, 1996.
34. Lees, J. A., Saito, M., Vidal, M., Valentine, M., Look, T., Harlow, E., Dyson, N., and Helin, K. The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol., 13: 7813-7825, 1993.
35. Buck, V., Allen, K. E., Sorensen, T., Bybee, A., Hijmans, E. M., Voorhoeve, P. M., Bernards, R., and La Thangue, N. B. Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene, 11: 31-38, 1995.
36. Itoh, A., Levinson, S. F., Morita, T., Kourembanas, S., Brody, J. S., and Mitsialis, S. A. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. Cell. Mol. Biol. Res., 41: 147-154, 1995.
37. Sardet, C., Vidai, M., Cobrinik, D., Geng, Y., Onufryk, C., Chen, A., and Weinberg, R. A. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. USA, 92: 2403-2407, 1995.
38. Corbeil, H. B., Whyte, P., and Branton, P. E. Characterization of transcription factor E2F complexes during muscle and neuronal differentiation. Oncogene, 11: 909-920, 1995.
39. Shin, E. K., Shin, A., Paulding, C., Schaffhausen, B., and Yee, A. S. Multiple change in E2F function and regulation occur upon muscle differentiation. Mol. Cell. Biol., 15: 2252-2262, 1995.
40. Kiess, M., Gill, R. M., and Hamel, P. A. Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130. during L6 myoblast differentiation. Cell Growth Differ., 6: 1287-1298, 1995.
41. Mudryj, M., Hiebert, S. W., and Nevins, J. R. A role for the adenovirus-inducible E2F transcription factor in a proliferation-dependent signal transduction pathway. EMBO J., 7: 2179-2184, 1990.
42. Gu, W., Schneider, J. W., Condorelli, G., Kaushal, S., Mahdavi, V., and Nadal Ginard, B. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell, 72: 309-324, 1993.
43. Cleveland, J. L., Dean, M., Rosenberg, N., Wang, J. Y. J., and Rapp, U. R. Tyrosine kinase oncogenes abrogate interteukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc. Mol. Cell. Biol., 9: 5685-5695, 1989.
44. Scholer, H. R., Hatzopoulos, A. K., Balling, R., Suzuki, N., and Gruss, P. A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J., 8: 2543-2550, 1989.
45. Sasaki, K., Murakami, T., Ogino, T., Takahashi, M., and Kawasaki, S. Flow cytometric estimation of cell cycle parameters using a monoclonal antibody to bromodeoxyuridine. Cytometry, 7: 391-395, 1986.