Are SOCS suppressors, regulators, and degraders?

Journal of Leukocyte Biology

Volumn 75, Issue 5, 2004, Pages 743-748

  Johnston, James A ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Cytokine signaling; JAKs; Janus kinase; STAT5

Indexed keywords

REGULATOR PROTEIN; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE;

CELL DIFFERENTIATION; CELL FATE; CONFERENCE PAPER; CYTOKINE RESPONSIVE ELEMENT; FEEDBACK SYSTEM; LYMPHOCYTE DIFFERENTIATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CYTOKINES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; REPRESSOR PROTEINS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TH2 CELLS; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES;

JANUS;

EID: 2342541086     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1003507     Document Type: Conference Paper

References (42)

1. Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Hara, T., Miyajima, A. (1995) A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14, 2816-2826.
2. Endo, T., Kanayama, K. (1997) Effects of TNF-α injection into the ovary on blood progesterone concentration in pseudopregnant rabbits. J. Med. 28, 405-410.
3. Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., Akira, S., Kishimoto, T. (1997) Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929.
4. Starr, R., Willson, T. A., Viney, E. M., Murray, L. J., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., Hilton, D. J. (1997) A family of cytokine-inducible inhibitors of signalling. Nature 387, 917-921.
5. Hilton, D. J., Richardson, R. T., Alexander, W. S., Viney, E. M., Willson, T. A., Sprigg, N. S., Starr, R., Nicholson, S. E., Metcalf, D., Nicola, N. A. (1998) Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA 95, 114-119.
6. Kile, B. T., Schulman, B. A., Alexander, W. S., Nicola, N. A., Martin, H. M., Hilton, D. J. (2002) The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci. 27, 235-241.
7. Verdier, F., Chretien, S., Muller, O., Varlet, P., Yoshimura, A., Gisselbrecht, S., Lacombe, C., Mayeux, P. (1998) Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein. J. Biol. Chem. 273, 28185-28190.
8. Ketteler, R., Moghraby, C. S., Hsiao, J. G., Sandra, O., Lodish, H. F., Klingmuller, U. (2003) The cytokine-inducible Scr homology domain-containing protein negatively regulates signaling by promoting apoptosis in erythroid progenitor cells. J. Biol. Chem. 278, 2654-2660.
9. Yasukawa, M., Ohminami, H., Yakushijin, Y., Arai, J., Hasegawa, A., Ishida, Y., Fujita, S. (1999) Fas-independent cytotoxicity mediated by human CD4+ CTL directed against herpes simplex virus-infected cells. J. Immunol. 162, 6100-6106.
10. Narazaki, M., Fujimoto, M., Matsumoto, T., Morita, Y., Saito, H., Kajita, T., Yoshizaki, K., Naka, T., Kishimoto, T. (1998) Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling. Proc. Natl. Acad. Sci. USA 95, 13130-13134.
11. Hansen, J. A., Lindberg, K., Hilton, D. J., Nielsen, J. H., Billestrup, N. (1999) Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins. Mol. Endocrinol. 13, 1832-1843.
12. Cohney, S. J., Sanden, D., Cacalano, N. A., Yoshimura, A., Mui, A., Migone, T. S., Johnston, J. A. (1999) SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell. Biol. 19, 4980-4988.
13. Nicholson, S. E., De Souza, D., Fabri, L. J., Corbin, J., Willson, T. A., Zhang, J. G., Silva, A., Asimakis, M., Farley, A., Nash, A. D., Metcalf, D., Hilton, D. J., Nicola, N. A., Baca, M. (2000) Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. USA 97, 6493-6498.
14. Mooney, R. A., Senn, J., Cameron, S., Inamdar, N., Boivin, L. M., Shang, Y., Furlanetto, R. W. (2001) Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. J. Biol. Chem. 276, 25889-25893.
15. Kamura, T., Burian, D., Yan, Q., Schmidt, S. L., Lane, W. S., Querido, E., Branton, P. E., Shilatifard, A., Conaway, R. C., Conaway, J. W. (2001) Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. J. Biol. Chem. 276, 29748-29753.
16. De Sepulveda, P., Ilangumaran, S., Rottapel, R. (2000) Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation. J. Biol. Chem. 275, 14005-14008.
17. Frantsve, J., Schwaller, J., Sternberg, D. W., Kutok, J., Gilliland, D. G. (2001) Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol. Cell. Biol. 21, 3547-3557.
18. Frantsve, J., Schwaller, J., Sternberg, D. W., Kutok, J., Gilliland, D. G. (2001) Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol. Cell. Biol. 21, 3547-3557.
19. Kamura, T., Sato, S., Haque, D., Liu, L., Kaelin Jr., W. G., Conaway, R. C., Conaway, J. W. (1998) The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12, 3872-3881.
20. Chen, X. P., Losman, J. A., Cowan, S., Donahue, E., Fay, S., Vuong, B. Q., Nawijn, M. C., Capece, D., Cohan, V. L., Rothman, P. (2002) Pim serine/threonine kinases regulate the stability of Socs-1 protein. Proc. Natl. Acad. Sci. USA 99, 2175-2180.
21. Zhang, J. G., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., Moritz, R. L., Cary, D., Richardson, R., Hausmann, G., Kile, B. J., Kent, S. B., Alexander, W. S., Metcalf, D., Hilton, D. J., Nicola, N. A., Baca, M. (1999) The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl. Acad. Sci. USA 96, 2071-2076.
22. Ohh, M., Takagi, Y., Aso, T., Stebbins, C. E., Pavletich, N. P., Zbar, B., Conaway, R. C., Conaway, J. W., Kaelin Jr., W. G. (1999) Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein. J. Clin. Invest. 104, 1583-1591.
23. Eyckerman, S., Broekaert, D., Verhee, A., Vandekerckhove, J., Tavernier, J. (2000) Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Lett. 486, 33-37.
24. Rodier, G., Montagnoli, A., Di Marcotullio, L., Coulombe, P., Draetta, G. F., Pagano, M., Meloche, S. (2001) p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 20, 6672-6682.
25. Haan, S., Ferguson, P., Sommer, U., Hiremath, M., McVicar, D. W., Heinrich, P. C., Johnston, J. A., Cacalano, N. A. (2003) Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. J. Biol. Chem. 278, 31972-31979.
26. Sasaki, A., Inagaki-Ohara, K., Yoshida, T., Yamanaka, A., Sasaki, M., Yasukawa, H., Koromilas, A. E., Yoshimura, A. (2003) The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. J. Biol. Chem. 278, 2432-2436.
27. Toniato, E., Chen, X. P., Losman, J., Flati, V., Donahue, L., Rothman, P. (2002) TRIM8/GERP RING finger protein interacts with SOCS-1. J. Biol. Chem. 277, 37315-37322.
28. Favre, H., Benhamou, A., Finidori, J., Kelly, P. A., Edery, M. (1999) Dual effects of suppressor of cytokine signaling (SOCS-2) on growth hormone signal transduction. FEBS Lett. 453, 63-66.
29. Pezet, A., Favre, H., Kelly, P. A., Edery, M. (1999) Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. J. Biol. Chem. 274, 24497-24502.
30. Kile, B. T., Alexander, W. S. (2001) The suppressors of cytokine signalling (SOCS). Cell. Mol. Life Sci. 58, 1627-1635.
31. Hanada, T., Yoshida, H., Kato, S., Tanaka, K., Masutani, K., Tsukada, J., Nomura, Y., Mimata, H., Kubo, M., Yoshimura, A. (2003) Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity 19, 437-450.
32. Dalpke, A. H., Opper, S., Zimmermann, S., Heeg, K. (2001) Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166, 7082-7089.
33. Stoiber, D., Kovarik, P., Cohney, S., Johnston, J. A., Steinlein, P., Decker, T. (1999) Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ. J. Immunol. 163, 2640-2647.
34. Kinjyo, I., Hanada, T., Inagaki-Ohara, K., Mori, H., Aki, D., Ohishi, M., Yoshida, H., Kubo, M., Yoshimura, A. (2002) SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17, 583-591.
35. Hortner, M., Nielsch, U., Mayr, L. M., Johnston, J. A., Heinrich, P. C., Haan, S. (2002) Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction. J. Immunol. 169, 1219-1227.
36. Roberts, A. I., Lee, L., Schwarz, E., Groh, V., Spies, T., Ebert, E. C., Jabri, B. (2001) NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J. Immunol. 167, 5527-5530.
37. Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., Hirano, T., Chien, K. R., Yoshimura, A. (2003) IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat. Immunol. 4, 551-556.
38. Lang, R., Pauleau, A. L., Parganas, E., Takahashi, Y., Mages, J., Ihle, J. N., Rutschman, R., Murray, P. J. (2003) SOCS3 regulates the plasticity of gp130 signaling. Natl. Immunol. 4, 546-550.
39. Croker, B. A., Krebs, D. L., Zhang, J. G., Wormald, S., Willson, T. A., Stanley, E. G., Robb, L., Greenhalgh, C. J., Forster, I., Clausen, B. E., Nicola, N. A., Metcalf, D., Hilton, D. J., Roberts, A. W., Alexander, W. S. (2003) SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol. 4, 540-545.
40. Egwuagu, C. E., Yu, C. R., Zhang, M., Mahdi, R. M., Kim, S. J., Gery, I. (2002) Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J. Immunol. 168, 3181-3187.
41. Seki, Y., Hayashi, K., Matsumoto, A., Seki, N., Tsukada, J., Ransom, J., Naka, T., Kishimoto, T., Yoshimura, A., Kubo, M. (2002) Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc. Natl. Acad. Sci. USA 99, 13003-13008.
42. Seki, Y., Inoue, H., Nagata, N., Hayashi, K., Fukuyama, S., Matsumoto, K., Komine, O., Hamano, S., Himeno, K., Inagaki-Ohara, K., Cacalano, N., O'Garra, A., Oshida, T., Saito, H., Johnston, J. A., Yoshimura, A., Kubo, M. (2003) SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat. Med. 9, 1047-1054.