Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII

Biochemical Journal

Volumn 379, Issue 2, 2004, Pages 461-469

  Woloszynek, Josh C ^a   Roberts, Marie ^a   Coleman, Trey ^a   Vogler, Carole ^b   Sly, William ^b   Semenkovich, Clay F ^a   Sands, Mark S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

glucuronidase; Enzyme replacement; Lysosomal storage; Mucopolysaccharidosis; Sly syndrome

Indexed keywords

ASSAYS; CELLS; COMPLEXATION; ENZYMES; GENES; MATHEMATICAL MODELS; METABOLISM; NUTRITION; PATHOLOGY; PROTEINS; TISSUE;

BIOCHEMICAL ASSAY; ENZYME REPLACEMNT THERAPY (ERT); MICROARRAY ANALYSIS; MULTIPLE PATHWAY;

DISEASES;

BETA GLUCURONIDASE; LYSOSOME ENZYME; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME DEFICIENCY; ENZYME REPLACEMENT; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; LIVER; LYSOSOME STORAGE DISEASE; MALE; MALNUTRITION; MOLECULAR DYNAMICS; MOUSE; MUCOPOLYSACCHARIDOSIS TYPE 7; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMALS; GENE EXPRESSION PROFILING; GLUCURONIDASE; LIVER; LYSOSOMES; MALE; MICE; MICE, MUTANT STRAINS; MUCOPOLYSACCHARIDOSIS VII; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

ANIMALIA; MURINAE;

EID: 2342508995     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031048     Document Type: Article

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