Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?

Journal of Nutrition

Volumn 132, Issue 8, 2002, Pages 2123-2126

  Coleman, Rosalind A ^a   Lewin, Tal M ^a   Van Horn, Cynthia G ^a   Gonzalez Baró, Maria R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Diabetes; Oxidation; Triacylglycerol

Indexed keywords

CORTICOTROPIN; FATTY ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETES MELLITUS; FATTY ACID OXIDATION; LIPID DEGRADATION; LIPOGENESIS; MITOCHONDRIAL RESPIRATION; MOLECULAR CLONING; NONHUMAN; PEROXISOME; RAT; REGULATORY MECHANISM;

ANIMALIA;

EID: 0036321931     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.8.2123     Document Type: Article

References (35)

1. Physiological and nutritional regulation of enzymes of triacylglycerol synthesis
2. A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis
3. Very long-chain acyl-CoA synthetases: Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids
4. Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling
5. Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: Evidence for functionally separate pools of acyl-CoA
6. Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats
7. Expression and characterization of recombinant rat acyl-CoA synthetases 1, 4, and 5: Selective inhibition by triacsin C and thiazolidinediones
8. Acyl-CoA synthetase in rat liver peroxisomes: Computer-assisted analysis of cell fractionation experiments
9. Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently
10. Molecular characterization and expression of rat acyl-CoA synthetase 3
11. Alternative translation initiation generates acyl-CoA synthetase 3 isoforms with heterogeneous amino termini
12. Role of arachidonic acid metabolism in ACTH-stimulated cortisol secretion by bovine adrenocortical cells
13. Essential fatty acid deficiency and adrenal cortical function in vitro
14. Cyclic AMP and arachidonic acid: A tale of two pathways
15. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues
16. Marked enhancement of acyl-CoA synthetase activity and RNA, paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker obese rats (fa/fa)
17. Rapid enhancement of acyl-CoA synthetase, LPL, and GLUT-4 mRNAs in adipose tissue of VMH rats
18. Regulation of gene expression by insulin and tumor necrosis factor α in 3T3-L1 cells: Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase
19. Marked reduction of acyl-CoA synthetase activity and mRNA in intra-abdominal visceral fat by physical exercise
20. Multiple promoters in rat acyl-CoA synthetase gene mediate differential expression of multiple transcripts with 5′-end heterogeneity
21. Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation
22. Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is medicated by a peroxisome proliferator response element in the C promoter
23. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARα)
24. Acyl-CoA are functionally channeled in liver: Potential role of acyl-CoA synthetase
25. Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes and mitochondrial associated membrane
26. A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes
27. Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency
28. Increased lipogenic capacity of the islets of obese rats. A role in the pathogenesis of NIDDM
29. Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
30. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
31. Lipotoxic heart disease in obese rats: Implications for human obesity
32. Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats
33. Mechanisms of insulin resistance in A-ZIP/F-1 fatless mice
34. Cellular mechanisms of insulin resistance
35. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism