Biodistribution, Kinetics, and Efficacy of Highly Phosphorylated and Non-phosphorylated β-Glucuronidase in the Murine Model of Mucopolysaccharidosis VII

Journal of Biological Chemistry

Volumn 276, Issue 46, 2001, Pages 43160-43165

  Sands, Mark S ^a   Vogler, Carole A ^b   Ohlemiller, Kevin K ^a   Roberts, Marie S ^a   Grubb, Jeffrey H ^b   Levy, Beth ^b   Sly, William S ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

USA

Indexed keywords

CELLS; DISEASES; SUBSTRATES; TISSUE;

BIODISTRIBUTION;

ENZYMES;

BETA GLUCURONIDASE; RECOMBINANT PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG UPTAKE; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME REPLACEMENT; EVOKED BRAIN STEM AUDITORY RESPONSE; HEARING LOSS; HISTOCHEMISTRY; HISTOPATHOLOGY; MOUSE; MUCOPOLYSACCHARIDOSIS TYPE 7; NONHUMAN; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; TISSUE DISTRIBUTION; ANIMAL; BRAIN STEM; CHEMISTRY; DISEASE MODEL; ENZYMOLOGY; FIBROBLAST; HUMAN; INSECT; KINETICS; LYSOSOME; METABOLISM; MUTATION; NEWBORN; PHENOTYPE; PHOSPHORYLATION; PROTEIN BINDING; TIME;

ANIMALIA; MURINAE;

ANIMALS; ANIMALS, NEWBORN; BRAIN STEM; DISEASE MODELS, ANIMAL; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FIBROBLASTS; GLUCURONIDASE; HUMANS; INSECTS; KINETICS; LYSOSOMES; MICE; MUCOPOLYSACCHARIDOSIS VII; MUTATION; PHENOTYPE; PHOSPHORYLATION; PROTEIN BINDING; RECOMBINANT PROTEINS; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0035900762     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107778200     Document Type: Article

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