Intracranial injection of recombinant adeno-associated virus improves cognitive function in a murine model of mucopolysaccharidosis type VII

Molecular Therapy

Volumn 3, Issue 3, 2001, Pages 351-358

  Frisella, W Anthony ^a   O'Connor, Lynn H ^a   Vogler, Carole A ^b   Roberts, Marie ^a   Walkley, Steve ^c   Levy, Beth ^b   Daly, Thomas M ^a   Sands, Mark S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Adeno associated virus; Central nervous system; Gene therapy; Lysosomal storage diseases; Morris water maze; glucuronidase

Indexed keywords

BETA GLUCURONIDASE; GANGLIOSIDE GM2; GANGLIOSIDE GM3; GLYCOSAMINOGLYCAN; LYSOSOME ENZYME;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION FUNCTION; DEGRADATION; DISEASE ASSOCIATION; DISEASE MODEL; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME LOCALIZATION; HIPPOCAMPUS; HISTOPATHOLOGY; INJECTION SITE; LIPID STORAGE; LYSOSOME; LYSOSOME STORAGE DISEASE; MALE; MAZE TEST; MENTAL DEFICIENCY; MOUSE; MUCOPOLYSACCHARIDOSIS TYPE 7; NEWBORN; NEWBORN PERIOD; NONHUMAN; PROTEIN EXPRESSION; TOXICITY; VIRUS RECOMBINANT;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MURINAE;

EID: 0034986419     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0274     Document Type: Article

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