Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an ∼700 kDa Apaf-1 containing apoptosome complex

Leukemia

Volumn 15, Issue 9, 2001, Pages 1388-1397

  Almond, J B ^a   Snowden, R T ^a   Hunter, A ^b   Dinsdale, D ^a   Cain, K ^a   Cohen, G M ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b LEICESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Apoptosis; Apoptosome; B CLL; Caspases; Proteasome inhibitors

Indexed keywords

ADAPTOR PROTEIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CALPASTATIN; CASPASE; CASPASE 2; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CHLORAMBUCIL; CYTOCHROME C; LACTACYSTIN; PREDNISOLONE; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; B CELL LEUKEMIA; B LYMPHOCYTE; CANCER CHEMOTHERAPY; CANCER STAGING; CELL MEMBRANE PERMEABILITY; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL;

EID: 0034844509     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402201     Document Type: Article

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