Fibromyalgia - From syndrome to disease. Overview of pathogenetic mechanisms

Journal of Rehabilitation Medicine, Supplement

Volumn , Issue 41, 2003, Pages 89-94

  Henriksson, Karl G ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Allodynia; Fibromyalgia; Hyperalgesia; Muscle pain

Indexed keywords

CYTOKINE; ESTROGEN; ESTROGEN RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; KETAMINE; LIDOCAINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHATE; PLACEBO; SODIUM CHLORIDE; STAPHYLOCOCCUS TOXOID; SUBSTANCE P;

ALLODYNIA; CEREBROSPINAL FLUID; CHRONIC PAIN; COGNITIVE DEFECT; CONFERENCE PAPER; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; DRUG EFFECT; DYSAUTONOMIA; EMOTIONAL STRESS; FATIGUE; FIBROMYALGIA; HUMAN; HYPERALGESIA; IMMUNOPATHOLOGY; INJECTION; MUSCULOSKELETAL DISEASE; MYALGIA; NEUROENDOCRINE SYSTEM; NOCICEPTION; NONHUMAN; PAIN; PAIN ASSESSMENT; PATHOGENESIS; PHYSICAL STRESS; PSYCHOSOCIAL CARE; SENSITIZATION; SLEEP DISORDER; SPINAL CORD DORSAL HORN;

FIBROMYALGIA; HUMANS; HYPERALGESIA; NOCICEPTORS; PAIN; SYNDROME;

EID: 0038305208     PISSN: 16501969     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (51)

1. Henriksson KG. Is fibromyalgia a central pain state? J Musculoskeletal Pain 2002; 10: 45-47.
2. Bennett RM. The clinical neurobiology of fibromyalgia and myofascial pain: Therapeutic implications. J Musculoskeletal Pain, 2002: 10: HMP, The Haworth Medical Press, Inc New York.
3. Bennett RM. Rheumatic Disease Clinics of North America. Rational Management of Fibromyalgia. W.B. Saunders Company 2002: 28: 2.
4. Wolfe F, Smythe HA, Yunus MB, Bennet RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: Report of the Multicenter Criteria Committee. Arthritis Rheum 1990; 22: 160-172.
5. Henriksson Ch, Qvarsebo Å, Carlberg U, Henriksson KG, Kjällman M, Lundberg G. Eight day diary in fibromyalgia. Abstract in 10th World Congress on Pain, IASP Press Seattle; 2002. p. 536.
6. Lindh C, Liu Z, Lyrenäs S, Ordeberg G, Nyberg F. Elevated cerebrospinal fluid substance P-like immunoreactivity in patients with painful osteoarthritis, but not in patients with rhizopatic pain from a herniated lumbar disc. Scand J Rheumatol 1997; 26: 468-472.
7. Vaeroy H, Helle R, Forre O, Kass E, Terenius L. Elevated CSF levels of substance P and high incidence of Raynaud's phenomenon in patients with fibromyalgia: New features for diagnosis. Pain 1988; 32: 21-26.
8. Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, et al. Elevated cerebrospinal levels of substance P in patients with fibromyalgia syndrome. Arthritis Rheum 1994; 37: 1593-1601.
9. Eneström S, Bengtsson A, Frödin T. Dermal IgG deposits and increase of mast cells in patients with fibromyalgia - Relevant findings or epiphenomena? Scand J Rheumatol 1997; 26: 308-313.
10. Gracely RH, Petzke F, Wolf JM, Clauw DJ. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 2002; 46: 1333-1343.
11. Crofford LJ, Clauw DJ. Fibromyalgia: Where are we a decade after the American College of rheumatology classification criteria were developed? Arthritis Rheum 2002; 46: 1136-1138.
12. Mountz JM, Bradley LA, Modell JG, Alexander RW, Triana-Alexander M, Aaron LA, et al. Fibromyalgia in women. Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels. Arthritis Rheum 1995; 38: 926-938.
13. Bradley LA, McKendree-Smith NL, Alberts KR, Alarcon GS, Mountz JM, Deutsch G. Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia. Current Rheumatology Reports 2000; 2: 141-148.
14. 2 laser stimulation in subjects with fibromyalgia syndrome. Pain 1994; 58: 185-193.
15. Lorentz J, Grasedck K, Bromm B. Middle and long latency somatosensory evoked potentials after painful laser stimulation in patients with fibromyalgia syndrome. Electroencephal Clin Neurophysiol 1996; 100: 165-168.
16. Arroyo JF, Cohen ML. Abnormal responses to electrocutaneous stimulation in fibromyalgia. J Rheumatol 1993; 20: 1925-1931.
17. Vecchiet L, Giamberardino MA, De Bigontina P, Dragani L. Comparative sensory evaluation of parietal tissues in painful and nonpainful areas in fibromyalgia and myofascial pain syndrome. In: Gebhart GF, Hammond DL, Jensen TS, editors. Progress in Pain Research and Management. IASP Press, Seattle, 1994; 2: p. 177-185.
18. Bendtsen L, Norregaard J, Jensen R, Olesen J. Evidence of qualitatively altered nociception in patients with fibromyalgia. Arthritis Rheum 1997; 40: 98-102.
19. Mense S. Neurobiological concepts of fibromyalgia - The possible role of descending spinal tracts. Scand J Rheumatol 2002; 29 suppl 113: 24-29.
20. Kosek E, Hansson P. Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. Pain 1997; 70: 41-51.
21. Kosek E, Ekholm J, Hansson P. Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls. Pain 1996; 64: 415-423.
22. Sörensen J, Bengtsson A, Bäckman E, Henriksson KG, Bengtsson M. Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine and ketamine. Scand J Rheumatol 1995; 24: 360-365.
23. Sörensen J, Bengtsson A, Ahlner J, Henriksson KG, Ekselius L. Fibromyalgia - Are there different mechanisms in the processing of pain? J Rheumatol 1997; 24: 1615-1621.
24. Graven-Nielsen T, Aspegren Kendall S, Henriksson KG, Bengtsson M, Sörensen J, Johnson A, et al. Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients. Pain 2000; 85: 483-491.
25. Sörenson J, Graven-Nielsen T, Henriksson KG, Bengtsson M, Arendt-Nielsen L. Hyperexcitability in fibromyalgia. J Rheumatology 1998; 25: 152-155.
26. Staud R, Vierck CJ, Cannon RL, Mauderli AP, Price DD. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Pain 2001; 91: 165-175.
27. Bengtsson A. The muscle in fibromyalgia. Rheumatol 2002; 41: 721-724.
28. Lund N, Bengtsson A, Thorborg P. Muscle tissue oxygen pressure in primary fibromyalgia. Scand J Rheumatol 1986; 15: 165-173.
29. Elert J, Kendall AS, Larsson B, Månsson B, Gerdle B. Chronic pain and difficulty in relaxing postural muscles in patients with fibromyalgia and chronic whiplash associated disorders. J Rheumatol 2001; 28: 1361-1368.
30. Bengtsson A, Henriksson KG, Larsson J. Reduced high-energy phosphate levels in the painful muscles of patients with primary fibromyalgia. Arthritis Rheum 1986; 29: 817-821.
31. Park JH, Phothimat P, Oates CO, Hernanz-Schulman M, Olsen NJ. Use of P-31 magnetic resonance spectroscopy to detect metabolic abnormalities in muscles of patients with fibromyalgia. Arthritis Rheum 1998; 41: 406-413.
32. Bengtsson M, Bengtsson A, Jorfeldt L. Diagnostic epidural opioid blockade in primary fibromyalgia at rest and during exercise. Pain 1989; 39: 171-180.
33. Bengtsson A, Henriksson KG, Jorfeldt L, Kågedal B, Lennmarken C, Lindström F. Primary fibromyalgia. A clinical and laboratory study of 55 patients. Scand J Rheumatol 1986; 15: 340-347.
34. Henriksson Ch, Carlberg U, Henriksson KG, Kjällman M, Lundberg G. Fibromyalgi. Rapport Stimulansbidrag för habilitering och rehabilitering. Socialstyrelsen, 2000; ISSN 1403-3348.
35. Lápossy E, Maleitzke R, Hrycaj P, Mennet W, Muller W. The frequency of transition of chronic low back pain to fibromyalgia. Scand J Rheumatol 1995; 24: 29-53.
36. Buskila D, Neumann L, Vaisberg G, Alkalay D, Wolfe F. Increased rates of fibromyalgia following cervical injury. A controlled study of 161 cases of traumatic injury. Arthritis Rheum 1997; 40: 446-452.
37. Buskila D, Neumann L. The development of widespread pain after injuries. J Musculoskeletal Pain 2002; 10: 261-267.
38. Vecchiet L. Muscle pain and aging. J Musculoskel Pain 2002; 10: 5-22.
39. Amandusson A, Hermanson O, Blomqvist A. Colocalization of oestrogen receptor immunoreactivity and preproenkephalin MRNA expression to neurons in the superficial laminae of the spinal and medullary dorsal horn of rats. Eur J Neurosci 1996; 8: 2440-2445.
40. Pillemer SR, Bradley LA, Crofford LJ, Moldofsky H, Chrousos GP. The neuroscience and endocrinology of fibromyalgia. Arthritis Rheum 1997; 40: 1928-1939.
41. Geenen R, Jacobs JWG, Bijlsma JWJ. Evaluation and management of endocrine dysfunction in fibromyalgia. Rheum Dis Clin N Am 2002; 28: 389-404.
42. Russell IJ, Vipraio GA. Serotonin (5HT) in serum and platelets (PLT) from fibromyalgia patients (FS) and normal controls (NC). Arthritis Rheum 1994; 37 (suppl): S214.
43. Russell IJ. Neurochemical pathogenesis of fibromyalgia syndrome. J Musculoskel Pain 1997; 7: 183-191.
44. Bennett RM, Clark SR, Campbell SM, Burckhardt CS. Low levels of somatomedin C in patients with the fibromyalgia syndrome. A possible link between sleep and muscle pain. Arthritis Rheum 1992; 35: 1113-1116.
45. Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, et al. Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 2001; 410: 471-475.
46. Ek M, Engblom D, Saha S, Blomqvist A, Jakobsson PJ, Ericsson-Dahlstrand A. Pathway across the blood-brain barrier. Nature 2001; 410: 430-431.
47. Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH. Cytokines play an aetiopathogenetic role in fibromyalgia: A hypothesis and pilot study. Rheumatol 2001; 40: 743-749.
48. Zachrisson O, Regland B, Jahreskog M, Jonsson M, Kron M, Gottfries CG. Treatment with staphylococcus toxoid in fibromyalgia/chronic fatigue syndrome - A randomised controlled trial. Eur J Pain 2002; 6: 455-466.
49. Martinez-Lavin M. The autonomic nervous system and fibromyalgia. J Musculoskel Pain 2002; 10: 221-228.
50. Watkins LR, Mair SF, Goehler LE. Immune activation; The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain 1995; 63: 289-302.
51. Henriksson Ch, Liedberg G. Factors of importance for work disability in women with fibromyalgia. J Rheumatol 2002; 27: 1271-1276.