Combination diet and exercise interventions for the treatment of dyslipidemia: An effective preliminary strategy to lower cholesterol levels?

Journal of Nutrition

Volumn 135, Issue 8, 2005, Pages 1829-1835

  Varady, Krista A ^a   Jones, Peter J H ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Cholesterol; Coronary heart disease; Diet; Dyslipidemia; Exercise

Indexed keywords

CHOLESTEROL; FISH OIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; SATURATED FATTY ACID; TRIACYLGLYCEROL;

CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DIET THERAPY; DYSLIPIDEMIA; EXERCISE; HUMAN; ISCHEMIC HEART DISEASE; LIFESTYLE; LOW FAT DIET; NUTRITIONAL SUPPORT; OAT; REVIEW;

EID: 23244465844     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.8.1829     Document Type: Review

References (60)

1. Ferdinand, K. C. (2004) The importance of aggressive lipid management in patients at risk: evidence from recent clinical trials. Clin. Cardiol. 27: 12-15.
2. Meagher, E. A. (2004) Addressing cardiovascular disease in women: focus on dyslipidemia. J. Am. Board Fam. Pract. 17: 424-437.
3. Watkins, L. O. (2004) Epidemiology and burden of cardiovascular disease. Clin. Cardiol. 27: 2-6.
4. National Cholesterol Education Program (2001) Third Report of the Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. NIH Publication no. 01-3670. National Institutes of Health, Bethesda, MD.
5. Bellosta, S., Paoletti, R. & Corsini, A. (2004) Safety of statins: focus on clinical pharmacokinetics and drug interactions. Circulation 109: 50-57.
6. Taylor, A. J., Grace, K., Swiecki, J., Hyatt, R., Gibbs, H., Sheikh, M., O'Malley, P. G. Lowenthal, S. P., West, M., Spain, J., Maneval, K. & Jones, D. L. (2001) Lipid-lowering efficacy, safety, and costs of a large-scale therapeutic statin formulary conversion program. Pharmacotherapy 21: 1130-1139.
7. de Denus, S., Spinier, S. A., Miller, K. & Peterson, A. M. (2004) Statins and liver toxicity: a meta-analysis. Pharmacotherapy 24: 584-591.
8. Lozada, A. & Dujovne, C. A. (1994) Drug interactions with fibric acids. Pharmacol. Ther. 63: 163-176.
9. Blane, G. F. (1987) Comparative toxicity and safety profile of fenofibrate and other fibric acid derivatives. Am. J. Med. 27: 26-36.
10. Kajinami, K. & Takekoshi, N. (2002) Cholesterol absorption inhibitors in development as potential therapeutics. Expert Opin. Investig. Drugs. 11: 831-835.
11. Yu-Poth, S., Zhao, G., Etherton, T., Naglak, M., Jonnalagadda, S. & Kris-Etherton, P. M. (1999) Effects of the National Cholesterol Education Program's Step I and Step II dietary intervention programs on cardiovascular disease risk factors: a meta-analysis. Am. J. Clin. Nutr. 69: 632-646.
12. Kris-Etherton, P. M., Binkoski, A. E., Zhao, G., Coval, S. M., Clemmer, K. F., Hecker, K. D., Jacques, H. & Etherton T. D. (2002) Dietary fat: assessing the evidence in support of a moderate-fat diet; the benchmark based on lipoprotein metabolism. Proc. Nutr. Soc. 61: 287-298.
13. Fahlman, M. M., Boardley, D., Lambert, C. P. & Flynn, M. G. (2002) Effects of endurance training and resistance training on plasma lipoprotein profiles in elderly women. J. Gerontol. A. Biol. Sci. Med. Sci. 57: 54-60.
14. Leon, A. S. & Sanchez, O. A. (2001) Response of blood lipids to exercise training alone or combined with dietary intervention. Med. Sci. Sports Exerc. 33:502-515.
15. Durstine, J. L., Grandjean, P. W., Davis, P. G., Ferguson, M. A., Alderson, N. L. & DuBose, K. D. (2001) Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports Med. 31: 1033-1062.
16. Miller, E. R., Erlinger, T. P., Young, D. R., Jehn, M., Charleston, J., Rhodes, D., Wasan, S. K. & Appel, L. J. (2002) Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT). Hypertension 40: 612-618.
17. Andersen, R. E., Wadden, T. A., Bartlett, S. J., Zemel, B., Verde T. J. & Franckowiak, S. C. (1999) Effects of lifestyle activity vs structured aerobic exercise in obese women: a randomized trial. J. Am. Med. Assoc. 281: 335-340.
18. Wilund, K. R., Ferrell, R. E., Phares, D. A., Goldberg, A. P. & Hagberg, J. M. (2002) Changes in high-density lipoprotein-C subfractions with exercise training may be dependent on cholesteryl ester transfer protein (CETP) genotype. Metabolism 51: 774-778.
19. Simkin-Silverman, L., Wing, R. R., Hansen, D. H., Klem, M. L., Pasagian-Macaulay, A. P., Meilahn, E. N. & Kuller, L. H. (1995) Prevention of cardiovascular risk factor elevations in healthy premenopausal women. Prev. Med. 24: 509-517.
20. Stefanick, M. L., Mackey, S., Sheehan, M., Ellsworth, N, Haskell, W. L. & Wood, P. D. (1998) Effects of diet and exercise in men and postmenopausal women with low levels of HDL cholesterol and high levels of LDL cholesterol. N. Engl. J. Med. 339: 12-20.
21. Williams, P. T., Krauss, R. M., Stefanick, M. L., Vranizan, K. M. & Wood, P. D. (1994) Effects of low-fat diet, calorie restriction, and running on lipoprotein subfraction concentrations in moderately overweight men. Metabolism 43: 655-663.
22. Niebauer, J., Hambrecht, R., Velich, T., Hauer, K., Marburger, C., Kalberer, B., Weiss, C., von Hodenberg, E., Schliert, G., Schuler, G., Zimmermann, R. & Kubler, W. (1997) Attenuated progression of coronary artery disease after 6 years of multifactorial risk intervention: role of physical exercise. Circulation 96: 2534-2541.
23. Sharman, M. J., Gomez, A. L., Kraemer, W. J. & Volek, J. S. (2004) Very low-carbohydrate and low-fat diets affect fasting lipids and postprandial lipemia differently in overweight men. J. Nutr. 134: 880-885.
24. Beauchesne-Rondeau, E., Gascon, A., Bergeron, J. & Jacques, H. (2003) Plasma lipids and lipoproteine in hypercholesterolemic men fed a lipid-lowering diet containing lean beef, lean fish, or poultry. Am. J. Clin. Nutr. 77: 587-593.
25. Leon, A. S., Gaskill, S. E., Rice, T., Bergeron, J., Gagnon, J., Rao, D. C., Skinner, J. S., Wilmore, J. H. & Bouchard, C. (2002) Variability in the response of HDL cholesterol to exercise training in the HERITAGE Family Study. Int. J. Sports Med. 23: 1-9.
26. Lavie, C. J. & Milani, R. V. (1996) Effects of cardiac rehabilitation and exercise training programs in patients > or = 75 years of age. Am. J. Cardiol. 78: 675-677.
27. McCarty, M. F. (2004) An elevation of triglycerides reflecting decreased triglyceride clearance may not be pathogenic-relevance to high-carbohydrate diets. Med. Hypotheses 63: 1065-1073.
28. Abeywardena, M. Y. (2003) Dietary fats, carbohydrates and vascular disease: Sri Lankan perspectives. Atherosclerosis 171: 157-161.
29. Archer, W. R., Lamarche, B., Deriaz, O., Landry, N., Corneau, L., Despres, J. P., Bergeron, J., Couture, P. & Bergeron, N. (2003) Variations in body composition and plasma lipids in response to a high-carbohydrate diet. Obes. Res. 11: 978-986.
30. Mamo, J. C., James, A. P., Scares, M. J., Purcell, K., Griffiths, D. & Schwenke, J. L. (2004) Carbohydrate rich diets exacerbate postprandial lipaemia in moderately dyslipidemic subjects, whereas red meat protein-enriched diets have no adverse effects. Asia Pac. J. Clin. Nutr. 13: 52-54.
31. Orzano, A. J. & Scott, J. G. (2004) Diagnosis and treatment of obesity in adults: an applied evidence-based review. J. Am. Board Fam. Pract. 17: 359-369.
32. Avenell, A., Broom, J., Brown, T. J., Poobalan, A., Aucott, L., Stearns, S. C., Smith, W. C., Jung, R. T., Campbell, M. K. & Grant, A. M. (2004) Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement. Health Technol. Assess. 8: 1-182.
33. Sowers, J. R. (2003) Obesity as a cardiovascular risk factor. Am. J. Med. 115: 37-41.
34. Schaefer, E. J., Lichtenstein, A. H., Lamon-Fava, S., McNamara, J. R., Schaefer, M. M., Rasmussen, H. & Ordovas, J. M. (1995) Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet. J. Am. Med. Assoc. 274: 1450-1455.
35. Davidson, M. H. (2002) Strategies to improve Adult Treatment Panel III guideline adherence and patient compliance. Am. J. Cardiol. 89: 8-20.
36. Van Horn, L. & Kavey, R. E. (1997) Diet and cardiovascular disease prevention: what works? Ann. Behav. Med. 19: 197-212.
37. Sherman, A. M., Bowen, D. J., Vitolins, M., Perri, M. G., Rosal, M. C., Sevick, M. A. & Ockene, J. K. (2000) Dietary adherence: characteristics and interventions. Control. Clin. Trials 21: 206-211.
38. Herrmann, W., Biermann, J. & Kostner, G. M. (1995) Comparison of effects of N-3 to N-6 fatty acids on serum level of lipoprotein(a) in patients with coronary artery disease. Am. J. Cardiol. 76: 459-462.
39. Warner, J. G., Ullrich, I. H., Albrink, M. J. & Yeater, R. A. (1989) Combined effects of aerobic exercise and omega-3 fatty acids in hyperlipidemic persons. Med. Sci. Sports Exerc. 21: 498-505.
40. Kelley, M. J., Hoover-Plow, J. Nichols-Bernhard, J. F., Verity, L. S. & Brewer, H. (1994) Oat bran lowers total and low-density lipoprotein cholesterol but not lipoprotein(a) in exercising adults with borderline hypercholesterolemia. J. Am. Diet. Assoc. 94: 1419-1421.
41. Berg, A., Konig, D., Deibert, P., Grathwohl, D., Berg, A., Baumstark, M. W., Franz & I. W. (2003) Effect of an oat bran enriched diet on the atherogenic lipid profile in patients with an increased coronary heart disease risk. A controlled randomized lifestyle intervention study. Ann. Nutr. Metab. 47:306-311.
42. Varady, K. A., Ebine, N., Vanstone, C. A., Parsons, W. E., Jones, P. J. (2004) Plant sterols and endurance training combine to favorably alter plasma lipid profiles in previously sedentary hypercholesterolemic adults after 8 wk. Am. J. Clin. Nutr. 80: 1159-1166.
43. Wijendran, V. & Hayes, K. C. (2004) Dietary n-6 and n-3 fatty acid balance and cardiovascular health. Annu. Rev. Nutr. 24: 597-615.
44. Hooper, L., Thompson, R. L., Harrison, R. A., Summerbell, C. D., Moore, H., Worthington, H. V., Durrington, P. N., Ness, A. R., Capps, N. E., Davey-Smith, G., Riemersma, R. A. & Ebrahim, S. B. (2004) Omega 3 fatty acids for prevention and treatment of cardiovascular disease. Cochrane Database Syst. Rev. 4: CD003177.
45. Lewis, A., Lookinland, S., Beckstrand, R. L. & Tiedeman, M. E. (2004) Treatment of hypertriglyceridemia with omega-3 fatty acids: a systematic review. J. Am. Acad. Nurse Pract. 16: 384-395.
46. Nestel, P., Shige, H., Pomeroy, S., Cehun, M., Abbey, M. & Raederstorff, D. (2002) The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am. J. Clin. Nutr. 76: 326-330.
47. Grimsgaard, S., Bonaa, K. H., Hansen, J. B. & Nordoy, A. (1997) Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am. J. Clin. Nutr. 66: 649-659.
48. Mori, T. A., Burke, V. & Puddey, I. B. (2000) Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am. J. Clin. Nutr. 71: 1085-1094.
49. Davidson, M. H., Maki, K. C., Kalkowski, J., Schaefer, E. J., Torri, S. A. & Drennan, K. B. (1997) Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. J. Am. Coll. Nutr. 16: 236-243.
50. Minihane, A. M., Khan, S., Leigh-Firbank, E. C., Talmud, P., Wright, J. W., Murphy, M. C., Griffin, B. A. & Williams, C. M. (2000) ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler. Thromb. Vasc. Biol. 20: 1990-1997.
51. Theobald, H. E., Chowienczyk, P. J., Whittall, R., Humphries, S. E. & Sanders, T. A. (2004) LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women. Am. J. Clin. Nutr. 79: 558-563.
52. Trinidad, T. P., Loyola, A. S., Mallillin, A. C., Valdez, D. H., Askali, F. C., Castillo, J. C., Resaba, R. L. & Masa, D. B. (2004) The cholesterol-lowering effect of coconut flakes in humans with moderately raised serum cholesterol. J. Med. Food 7: 136-140.
53. Romero, A. L., Romero, J. E., Galaviz, S. & Fernandez, M. L. (1998) Cookies enriched with psyllium or oat bran lower plasma LDL cholesterol in normal and hypercholesterolemic men from Northern Mexico. J. Am. Coll, Nutr. 17: 601-608.
54. Gerhardt, A. L. & Gallo, N. B. (1998) Full-fat rice bran and oat bran similarly reduce hypercholesterolemia in humans. J. Nutr. 128: 865-869.
55. Behall, K. M., Scholfield, D. J. & Hallfrisch, J. (1997) Effect of β-glucan level in oat fiber extracts on blood lipids in men and women. J. Am. Coll. Nutr. 16: 46-51.
56. Kerckhoffs, D. A., Brouns, F., Hornstra, G. & Mensink, R. P. (2002) Effects on the human serum lipoprotein profile of β-glucan, soy protein and isoflavones, plant sterols and stanols, garlic and tocotrienols. J. Nutr. 132: 2494-2505.
57. Davidson, M. H., Dugan, L. D., Burns, J. H., Bova, J., Story, K. & Drennan, K. B. (1991) The hypocholesterolemic effects of beta-glucan in oatmeal and oat bran. A dose-controlled study. J. Am. Med. Assoc. 265: 1833-1839.
58. Katan, M. B., Grundy, S. M., Jones, P., Law, M., Miettinen, T. & Paoletti, R.; Stresa Workshop Participants. (2003) Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo. Clin. Proc. 78: 965-978.
59. Ostlund, R. E. (2004) Phytosterols and cholesterol metabolism. Curr. Opin. Lipidol. 15: 37-41.
60. St-Onge, M. P. & Jones, P. J. (2003) Phytosterols and human lipid metabolism: efficacy, safety, and novel foods. Lipids 38: 367-375.