Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene

Carcinogenesis

Volumn 25, Issue 4, 2004, Pages 637-643

  Boyiri, Telih ^a   Guttenplan, Joseph ^b,c   Khmelnitsky, Michael ^b   Kosinska, Wieslawa ^b   Lin, Jyh Ming ^a   Desai, Dhimant ^a   Amin, Shantu ^a   Pittman, Brian ^a   El Bayoumy, Karam ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

^b NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHRYSENE DERIVATIVE; DNA; TRIOCTANOIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER INCIDENCE; CARCINOGEN TESTING; CHEMICAL CARCINOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DECAPITATION; DNA ADDUCT; FEMALE; GENE STRUCTURE; GENETIC ANALYSIS; HISTOPATHOLOGY; IN VIVO STUDY; MUTAGENESIS; MUTANT; MUTATIONAL ANALYSIS; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; RAT; TRANSGENIC ANIMAL;

ADENOCARCINOMA; ADENOMA; ADMINISTRATION, ORAL; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHRYSENES; DNA ADDUCTS; ENVIRONMENTAL POLLUTANTS; FEMALE; FIBROADENOMA; MAMMARY NEOPLASMS, EXPERIMENTAL; MUTATION, MISSENSE; POINT MUTATION; RATS; RATS, INBRED F344; REFERENCE VALUES; TRANSCRIPTION FACTORS; VIRAL PROTEINS;

EID: 10844241185     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh040     Document Type: Article

References (49)

1. Jemal,A., Murray,T., Samuels,A., Ghafuor,A., Ward,E. and Thun,M.J. (2003) Cancer statistics, 2003. CA Cancer J. Clin., 53, 5-26.
2. WHO The World Health Report. World Health Organization, Geneva, 1997.
3. Wynder,E.L., Cohen,L.A., Muscat,J.E., Winters,B., Dwyer,J.T. and Blackburn,G. (1997) Breast cancer: weighing the evidence for a promoting role of dietary fat. J. Natl Cancer Inst., 89, 766-775.
4. Lipworth,L. (1995) Epidemiology of breast cancer. Eur. J. Cancer Prev., 4, 7-30.
5. Doll,R. (1996) Nature and nurture: possibilities for cancer control (commentary). Carcinogenesis, 17, 177-184.
6. Willett,W.C., Colditz,G.A. and Mueller,N. (1996) Strategies for minimizing cancer risk. Sci. Am., 88-95.
7. Cohen,L.A., Rose,D.P. and Wynder,E.L. (1993) A rationale for dietary intervention in postmenopausal breast cancer patients: an update. Nutr. Cancer, 19, 1-10.
8. El-Bayoumy,K., Johnson,B.E., Roy,A.K., Upadhyaya,P. and Partian,S.J. (1994) Biomonitoring of nitropolynuclear aromatic hydrocarbons via protein and DNA adducts. Health Effects Institute, Research Report Number 64, April.
9. Fu,P.P. and Herreno-Saenz,D. (1999) Nitro-polycyclic aromatic hydrocarbons: a class of genotoxic environmental pollutants. Environ. Carcinogen. Ecotoxicol. Rev., C17, 1-43.
10. Tokiwa,H., Sera,N., Horikawa,K., Nakanishi,Y. and Shigematu,N. (1993) The presence of mutagens/carcinogens in the excised lung and analysis of lung cancer induction. Carcinogenesis, 14, 1933-1938.
11. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans (1989) Diesel and Gasoline Engine Exhausts and Some Nitroarenes. IARC Scientific Publications, IARC, Lyon, vol. 46, pp. 1-458.
12. Eighth Report on Carcinogens, National Toxicology Program (full report) (1998) US Department of Health and Human Services, Washington DC.
13. El-Bayoumy,K., Rivenson,A., Upadhyaya,P., Chae,Y.-H. and Hecht,S.S. (1993) Induction of mammary cancer by 6-nitrochrysene in female CD rats. Cancer Res., 53, 3719-3722.
14. Chae,Y.-H., Yun,C.-H., Guengerich,F.P., Kadlubar,F.F. and El-Bayoumy,K. (1993) Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene. Cancer Res., 53, 2028-2034.
15. Boyiri,T., Leszczynska,J., Desai,D., Amin,S., Nixon,D.W. and El-Bayoumy,K. (2002) Metabolism and DNA binding of the environmental pollutant 6-nitrochrysene in primary culture of human breast cells and in cultured MCF-10A, MCF-7 and MDA-MB-435s cell lines. Int. J. Cancer, 100, 395-400.
16. Zwirner-Baier,I. and Neumann,H.-G. (1999) Genetic toxicology and environmental mutagenesis. Mutat. Res., 441, 135-144.
17. 32P-Postlabelling analysis of DNA adducts in human and rat mammary epithelial cells. Carcinogenesis, 9, 1071-1072.
18. Perera,F.P., Estabrook,A., Hewer,A., Channing,K., Rundle,A., Mooney,L.A., Whyatt,R. and Phillips,D.H. (1995) Carcinogen-DNA adducts in human breast tissue. Cancer Epidemiol. Biomarkers Prev., 4, 233-238.
19. Li,D., Wang,M., Dhingra,K. and Hittleman,W.N. (1996) Aromatic DNA adducts in adjacent tissues of breast cancer patients: clues to breast cancer etiology. Cancer Res., 56, 287-293.
20. Pfau,W., Stone,E.M., Brockstedt,U., Carmichael,P.L., Marquardt,H. and Phillips,D.H. (1998) DNA adducts in human breast tissue: association with N-acetyltransferase-2 (NAT2) and NAT1 genotypes. Cancer Epidemiol. Biomarkers Prev., 7, 1019-1025.
21. Wang,M., Dhingra,K., Hittleman,W.N., Liehr,J.G., de Andrade,M. and Li,D. (1996) Lipid peroxidation-induced putative malondialdehyde-DNA adducts in human breast tissues. Cancer Epidemiol. Biomarkers Prev., 5, 705-710.
22. Chae,Y.-H., Delclos,K.B., Blaydes,B. and El-Bayoumy,K. (1996) Metabolism and DNA binding of the environmental colon carcinogen 6-nitrochrysene in rats. Cancer Res., 56, 2052-2058.
23. Neumann,M.S. and Cathcart,J.A. (1940) The orientation of chrysene. J. Org. Chem., 5, 618-622.
24. El-Bayoumy,K., Desai,D., Boyiri,T., Rosa,J., Krzeminki,J., Sharma,A.K., Pittman,B. and Amin,S. (2002) Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland. Chem. Res. Toxicol., 15, 972-978.
25. Russo,A., Grasso,G., Sanfilippo,G. and Giannone,G. (1976) [Criteria for applying target biopsy and histological features in the diagnosis of gastric cancer in situ (author's transl)]. Tumori., 62, 39-46.
26. Jakubczak,J.L., Merlino,G., French,J.E., Muller,W.J., Paul,B., Adhya,S. and Garges,S. (1996) Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage transgene target. Proc. Natl Acad. Sci. USA, 93, 9073-9078.
27. Zimmer,D.M., Harbach,P.R., Mattes,W.B. and Aaron,C.S. (1999) Comparison of mutant frequencies at the transgenic lambda lacl and cll/ cl loci in control and ENU-treated Big Blue mice. Environ. Mol. Mutagen., 33, 249-256.
28. Gollapudi,B.B., Jackson,K.M. and Stott,W.T. (1999) Hepatic lacl and cll mutation in transgenic (LIZ) rats treated with dimethylnitrosamine. Mutat. Res., 419, 131-135.
29. Davies,R., Gant,T.W., Smith,L.L. and Styles,J.A. (1999) Tamoxifen induces G,C → T,A mutations in the cll gene in the liver of lambda/lacI transgenic rats but not at 5′-CpG-3′ dinucleotide sequences as found in the lacI transgene. Carcinogenesis, 20, 1351-1356.
30. Swiger,R.R., Cosentino,L., Shima,N., Bielas,J.H., Cruz-Munoz,W. and Heddle,J.A. (1999) The cll locus in the Muta™ Mouse System. Environ. Mol. Mutagen., 34, 201-207.
31. Hochberg,Y. and Tamhane,A.C. (1987) Multiple Comparisons Procedures. John Wiley & Sons, New York, pp. 3-5.
32. Miller,R.G. (1981) Simultaneous Statistical Inference. Springer-Verlag, New York, 2nd Edn, p. 37.
33. Fleiss,J.L. (1986) The Design and Analysis of Clinical Experiments. Wiley & Sons, New York, pp. 220-240.
34. Zhang,S., Glickman,B.W. and de Boer,J.G. (2001) Spontaneous mutation of the lacI transgene in rodents: absence of species, strain and insertion-site influence. Environ. Mol. Mutagen., 37, 141-146.
35. Shane,B.S., Smith-Dunn,D.L., de Boer,J.G., Glickman,B.W. and Cunningham,M.L. (2000) Mutant frequencies and mutation spectra of dimethylnitrosamine (DMN) at the lacI and cII loci in the livers of Big Blue transgenic mice. Mutat. Res., 452, 197-210.
36. Stuart,G.R., Thorleifson,E., Okochi,E., de Boer,J.G., Ushijima,T., Nagao,M. and Glickman,B.W. (2000) Interpretation of mutational spectra from different genes: analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue rats. Mutat. Res., 452, 101-121.
37. Ono,T., Ikehata,H., Nakamura,S., Saito,Y., Hosoi,Y., Takai,Y., Yamada,S., Onodera,J. and Yamamoto,K. (2000) Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse. Mutat. Res., 447, 165-177.
38. Greenblatt,M.S., Bennett,W.P., Hollstein,M. and Harris,C.C. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54, 4855-4878.
39. Russo,J., Tay,L.K. and Russo,I.H. (1982) Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res. Treat., 2, 5-73.
40. Imaida,K., Uneyama,C., Ogasawara,H., Hayashi,S., Fukuhara,K., Miyata,N. and Takahashi,M. (1992) Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species. Cancer Res., 52, 1542-1545.
41. El-Bayoumy,K. (1992) Environmental carcinogens that may be involved in human breast cancer etiology. Chem. Res. Toxicol., 5, 585-590.
42. Okochi,E., Watanabe,N., Shimade,U., Takahashi,S., Wakazono,K., Shirai,T., Sugimura,T., Nagao,M. and Ushijima,T. (1999) Preferential induction of guanine deletion at 5′-GGGA-3 in rat mammary glands by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcinogenesis, 20, 1933-1938.
43. Okonogi,H., Stuart,G.R., Okochi,E., Ushijima,T., Sugimura,T., Glickman,B.W. and Nagao,M. (1997) Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene. Mutat. Res., 395, 93-99.
44. 1. Carcinogenesis, 17, 2347-2356.
45. Dycaico,M.J., Provost,G.S., Kretz,P.L., Ransom,S.L., Moores,J.C. and Short,J.M. (1994) The use of shuttle vectors for mutation analysis in transgenic mice and rats. Mutat. Res., 307, 461-468.
46. Stuart,G.R., Holcroft,J., de Boer,J.G. and Glickman,B.W. (2000) Prostate mutations in rats induced by the suspected human carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Res., 60, 266-268.
47. Lefevre,P.A., Tinwell,H. and Ashby,J. (1997) Mutagenicity of the potent rat hepatocarcinogen 6BT to the liver of transgenic (lacI) rats: consideration of a reduced mutation assay protocol. Mutagenesis, 12, 45-47.
48. Manjanatha,M.G., Shelton,S.D., Culp,S.J., Blankenship,L.R. and Casciano,D.A. (2000) DNA adduct formation and molecular analysis of in vivo lacI mutations in the mammary tissue of Big Blue rats treated with 7,12-dimethylbenz(a)anthracene. Carcinogenesis, 21, 265-273.
49. Ruggeri,B., DiRado,M., Zhang,S.Y., Bauer,B., Goodrow,T. and Klein-Szanto,A.J. (1993) Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. Proc. Natl Acad. Sci. USA, 90, 1013-1017.