Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat

European Journal of Neuroscience

Volumn 22, Issue 1, 2005, Pages 21-27

  Lin, Suizhen ^a,c   Wei, Xing ^b   Bales, Kelly R ^a   Paul, Aaron B C ^a   Ma, Zhizhong ^b   Yan, Guangmei ^c   Paul, Steven M ^a   Du, Yansheng ^b  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Apoptosis; Granule neurons; Minocycline; p38 mitogen activated protein kinase

Indexed keywords

BILIRUBIN; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DISEASE; CELL LOSS; CEREBELLUM; CEREBELLUM HYPOPLASIA; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GRANULE CELL; HOMOZYGOSITY; HYPERBILIRUBINEMIA; IN VITRO STUDY; IN VIVO STUDY; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT; RAT STRAIN;

ANIMALS; ANTI-BACTERIAL AGENTS; CELLS, CULTURED; CEREBELLAR CORTEX; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENZYME INHIBITORS; HOMOZYGOTE; HUMANS; INFANT, NEWBORN; JAUNDICE, NEONATAL; KERNICTERUS; MINOCYCLINE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PURKINJE CELLS; RATS; RATS, GUNN;

EID: 23044460297     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2005.04182.x     Document Type: Article

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