The JNK and p38 signal transduction following axotomy

Restorative Neurology and Neuroscience

Volumn 19, Issue 1-2, 2001, Pages 29-39

  Herdegen, Thomas ^a   Waetzig, Vicki ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

c Jun; Cell body response; JNKs; p38; Regeneration

Indexed keywords

CELL ADHESION MOLECULE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ARTICLE; CELL ACTIVITY; CELL DIFFERENTIATION; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; MITOSIS INHIBITION; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE CONDUCTION; NERVE FIBER; NERVE FIBER TRANSECTION; NERVE FIBER TRANSPORT; NERVE REGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SYNAPSE;

ANIMALS; AXOTOMY; CELL SURVIVAL; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE REGENERATION; NEURITES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 0035554343     PISSN: 09226028     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (93)

1. Matrix survival signaling: From fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase
2. Growth regulation via p38 mitogen-activated protein kinase in developing liver
3. Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia
4. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
5. The role of local actin instability in axon formation
6. Repetitive electroconvulsive seizures induce activity of c-Jun N-terminal kinase and compartment-specific desensitization of c-Jun phosphorylation in the rat brain
7. Fetal spinal cord transplants and exogenous neurotrophic support enhance c-Jun expression in mature axotomized neurons after spinal cord injury
8. Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-lb/Jun N-terminal kinase-3
9. Expression of Jun, Fos, and ATF-2 proteins in axotomized explanted and cultured adult rat dorsal root ganglia
10. Differential expression of SAPK isoforms in the rat brain. An in situ hybridisation study in the adult rat brain and during post-natal development
11. Stress activated protein kinases, a novel family of mitogen-activated protein kinases, are heterogeneously expressed in the adult rat brain and differentially distributed from extracellular-signal-regulated protein kinases
12. c-Jun regulation in rat neonatal motoneurons postaxotomy
13. Axonal regeneration from CNS neurons in the cerebellum and brainstem of adult rats: Correlation with the patterns of expression and distribution of messenger RNAs for L1, CHL1, c-jun and growth-associated protein-43
14. The p38 pathway provides negative feedback for Ras proliferative signaling
15. Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons
16. Axonal transport of activating transcription factor-2 is modulated by nerve growth factor in nociceptive neurons
17. Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons
18. Intrinsic neuronal determinants of regeneration
19. Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy
20. Evolution of the Purkinje cell response to injury and regenerative potential during postnatal development of the rat cerebellum
21. Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells
22. CEP-1347/KT7515 prevents motor neuronal programmed cell death and injury-induced dedifferentiation in vivo
23. Cyclic AMP-induced neuronal differentiation via activation of p38 mitogen-activated protein kinase
24. An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons
25. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury
26. Inducible and constitutive transcription factors in the mammalian nervous system: Control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
27. The c-Jun transcription factor bipotential mediator of neuronal death, survival and regeneration
28. AP-1 proteins in the adult brain: Facts and fiction about effectors of neuroprotection and neurodegeneration
29. c-jun is dispensable for developmental cell death and axogenesis in the retina
30. Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
31. Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2
32. Expression of c-jun in the lateral vestibular nucleus following spinal cord injury and peripheral nerve graft transplantation in adult rats
33. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions
34. Rapid phosphorylation of Elk-1 transcription factor and activation of MAP kinase signal transduction pathways in response to visual stimulation
35. Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons
36. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
37. Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia In vivo
38. Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration
39. Microinjection of activated phosphatidylinositol-3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway
40. Up-regulation of ERK (MAP kinase) and MEK (MAP kinase kinase) transcription after rat facial nerve transection
41. Co-expression of c-Jun and ATF2 characterizes the surviving retinal ganglion cells which maintain axonal connections after partial optic nerve injury
42. Human c-Jun N-terminal kinase expression and activation in the nervous system
43. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
44. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
45. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
46. Stress-activated protein kinases are negatively regulated by cell density
47. Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: Evidence for a role in the regeneration process
48. Distinct localization of SAPK isoforms in neurons of adult mouse brain implies multiple signaling modes of SAPK pathway
49. Constitutive activity and differential localization of p38alpha and p38beta MAPKs in adult mouse brain
50. Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation
51. Bcl-2 overexpression per se does not promote regeneration of neonatal crushed optic fibers
52. Neuronal activity-dependent cell survival mediated by transcription factor MEF2
53. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway
54. Developmental expression in the mouse nervous system of the p493F12 SAP kinase
55. Beta-arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3
56. Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures
57. Selective expression of JNK isoforms and stress-specific JNK activity in different neural cell lines
58. JNK and p38 stresskinases - Degenerative effectors of signal-transduction-cascades in the nervous system
59. Regulation and function of the JNK subgroup of MAP kinases
60. Cdc42Hs, but not Racl, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiting p38/RK
61. Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells
62. Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: Possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis
63. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase
64. Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration
65. Inhibition of aberrant and constitutive phosphorylation of the high-molecular-mass neurofilament subunit by CEP-1347 (KT7515), an inhibitor of the stress-activated protein kinase signaling pathway
66. Activation of novel protein kinases C delta and C epsilon upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts
67. Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation
68. Expression of cfos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra
69. The cytoskeletal network controls c-Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell-type-specific manner
70. Stress-induced activation of c-Jun N-terminal kinase in sensory ganglion neurons: Accumulation in nuclear domains enriched in splicing factors and distribution in perichromatin fibrils
71. Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway
72. Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: Differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
73. Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells
74. Ras-signaling pathways: Positive and negative regulation of tau expression in PC12 cells
75. Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation
76. MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo
77. Seizure-induced neuronal death is associated with induction of c-Jun N-terminal kinase and is dependent on genetic background
78. Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT)
79. Retinal ganglion cells lose trophic responsiveness after axotomy
80. Differential and prolonged expression of Fos-lacZ and Jun-lacZ in neurons, glia, and muscle following sciatic nerve damage
81. Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase lb (Jun N-terminal kinase-3)
82. The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
83. Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus
84. Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells
85. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest
86. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
87. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways
88. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
89. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation
90. Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli
91. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
92. MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton
93. Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase