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Volumn 57, Issue 6, 2005, Pages 421-431

Eph-modulated cell morphology, adhesion and motility in carcinogenesis

Author keywords

Adhesion; Eph; Invasion; Metastasis; Motility; Neo angiogenesis; RTK

Indexed keywords

EPHRIN; EPHRIN RECEPTOR; INTEGRIN; PROTEIN TYROSINE KINASE;

EID: 23044435769     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540500138337     Document Type: Review
Times cited : (61)

References (87)
  • 1
    • 0036303033 scopus 로고    scopus 로고
    • Mechanisms and functions of Eph and ephrin signalling
    • Kullander, K., and Klein, R. (2002) Mechanisms and functions of Eph and ephrin signalling. Nat. Rev. Mol. Cell Biol. 3, 475-486.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 475-486
    • Kullander, K.1    Klein, R.2
  • 2
    • 5044240692 scopus 로고    scopus 로고
    • Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly
    • Poliakov, A., Cotrina, M., and Wilkinson, D. G. (2004) Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev. Cell. 7, 465-480.
    • (2004) Dev. Cell , vol.7 , pp. 465-480
    • Poliakov, A.1    Cotrina, M.2    Wilkinson, D.G.3
  • 3
    • 0036668277 scopus 로고    scopus 로고
    • Eph family functions from an evolutionary perspective
    • Drescher, U. (2002) Eph family functions from an evolutionary perspective. Curr. Opin. Genet. Dev. 12, 397-402.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 397-402
    • Drescher, U.1
  • 5
    • 0037272448 scopus 로고    scopus 로고
    • Molecular control of arterial-venous blood vessel identity
    • Adams, R. H. (2003) Molecular control of arterial-venous blood vessel identity. J. Anat. 202, 105-112.
    • (2003) J. Anat. , vol.202 , pp. 105-112
    • Adams, R.H.1
  • 6
    • 0037605875 scopus 로고    scopus 로고
    • Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells
    • Sharfe, N., Freywald, A., Toro, A., and Roifman, C. M. (2003) Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells. J. Immunol. 170, 6024-6032.
    • (2003) J. Immunol. , vol.170 , pp. 6024-6032
    • Sharfe, N.1    Freywald, A.2    Toro, A.3    Roifman, C.M.4
  • 7
    • 11244321555 scopus 로고    scopus 로고
    • EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation
    • Yu, G., Luo, H., Wu, Y., and Wu, J. (2004) EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J. Biol. Chem. 279, 55531-9.
    • (2004) J. Biol. Chem. , vol.279 , pp. 55531-55539
    • Yu, G.1    Luo, H.2    Wu, Y.3    Wu, J.4
  • 8
    • 7244245371 scopus 로고    scopus 로고
    • A relative signalling model for the formation of a topographic neural map
    • Reber, M., Burrola, P., and Lemke, G. (2004) A relative signalling model for the formation of a topographic neural map. Nature 431, 847-853.
    • (2004) Nature , vol.431 , pp. 847-853
    • Reber, M.1    Burrola, P.2    Lemke, G.3
  • 9
    • 0035287509 scopus 로고    scopus 로고
    • Eph receptors and neural plasticity
    • Gerlai, R. (2001) Eph receptors and neural plasticity. Nat. Rev. Neurosci. 2, 205-209.
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 205-209
    • Gerlai, R.1
  • 10
    • 0036785161 scopus 로고    scopus 로고
    • Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis
    • Nakamoto, M., and Bergemann, A. D. (2002) Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis. Microsc. Res. Tech. 59, 58-67.
    • (2002) Microsc. Res. Tech. , vol.59 , pp. 58-67
    • Nakamoto, M.1    Bergemann, A.D.2
  • 12
    • 4644290521 scopus 로고    scopus 로고
    • Eph receptor tyrosine kinases in tumor and tumor microenvironment
    • Brantley-Sieders, D., Parker, M., and Chen, J. (2004) Eph receptor tyrosine kinases in tumor and tumor microenvironment. Curr. Pharm. Des. 10, 3431-3442.
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 3431-3442
    • Brantley-Sieders, D.1    Parker, M.2    Chen, J.3
  • 13
    • 0034693857 scopus 로고    scopus 로고
    • Eph receptors and ephrin ligands: Embryogenesis to tumorigenesis
    • Dodelet, V. C., and Pasquale, E. B. (2000) Eph receptors and ephrin ligands: embryogenesis to tumorigenesis. Oncogene 19, 5614-5619.
    • (2000) Oncogene , vol.19 , pp. 5614-5619
    • Dodelet, V.C.1    Pasquale, E.B.2
  • 14
    • 0037103042 scopus 로고    scopus 로고
    • Human osteosarcoma expresses specific ephrin profiles: Implications for tumorigenicity and prognosis
    • Varelias, A., Koblar, S. A., Cowled, P. A., Carter, C. D., and Clayer, M. (2002) Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis. Cancer 95, 862-869.
    • (2002) Cancer , vol.95 , pp. 862-869
    • Varelias, A.1    Koblar, S.A.2    Cowled, P.A.3    Carter, C.D.4    Clayer, M.5
  • 15
    • 2442419137 scopus 로고    scopus 로고
    • Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application. Biochem
    • Fox, B. P. and Kandpal, R. P. (2004) Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application. Biochem. Biophys. Res. Commun. 318, 882-892.
    • (2004) Biophys. Res. Commun. , vol.318 , pp. 882-892
    • Fox, B.P.1    Kandpal, R.P.2
  • 16
    • 0025373765 scopus 로고
    • Overexpression confers an oncogenic potential upon the eph gene
    • Maru, Y., Hirai, H., and Takaku, F. (1990) Overexpression confers an oncogenic potential upon the eph gene. Oncogene 5, 445-447.
    • (1990) Oncogene , vol.5 , pp. 445-447
    • Maru, Y.1    Hirai, H.2    Takaku, F.3
  • 18
    • 0037093097 scopus 로고    scopus 로고
    • Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior
    • Carles-Kinch, K., Kilpatrick, K. E., Stewart, J. C., and Kinch, M. S. (2002) Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior. Cancer Res. 62, 2840-2847.
    • (2002) Cancer Res. , vol.62 , pp. 2840-2847
    • Carles-Kinch, K.1    Kilpatrick, K.E.2    Stewart, J.C.3    Kinch, M.S.4
  • 19
    • 0035865227 scopus 로고    scopus 로고
    • Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells
    • Gale, N. W., Baluk, P., Pan, L., Kwan, M., Holash, J., DeChiara, T. M., McDonald, D. M., and Yancopoulos, G. D. (2001) Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev. Biol. 230, 151-160.
    • (2001) Dev. Biol. , vol.230 , pp. 151-160
    • Gale, N.W.1    Baluk, P.2    Pan, L.3    Kwan, M.4    Holash, J.5    Dechiara, T.M.6    McDonald, D.M.7    Yancopoulos, G.D.8
  • 20
    • 0036679339 scopus 로고    scopus 로고
    • Ephrin-B ligands play a dual role in the control of neural crest cell migration
    • Santiago, A. and Erickson, C. A. (2002) Ephrin-B ligands play a dual role in the control of neural crest cell migration. Development 129, 3621-3632.
    • (2002) Development , vol.129 , pp. 3621-3632
    • Santiago, A.1    Erickson, C.A.2
  • 21
    • 0033773863 scopus 로고    scopus 로고
    • Protein tyrosine kinases in malignant melanoma
    • Easty, D. J. and Bennett, D. C. (2000) Protein tyrosine kinases in malignant melanoma. Melanoma Res. 10, 401-411.
    • (2000) Melanoma Res. , vol.10 , pp. 401-411
    • Easty, D.J.1    Bennett, D.C.2
  • 22
    • 0034282516 scopus 로고    scopus 로고
    • Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules
    • Chiari, R., Hames, G., Stroobant, V., Texier, C., Maillere, B., Boon, T., and Coulie, P. G. (2000) Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules. Cancer Res. 60, 4855-4863.
    • (2000) Cancer Res. , vol.60 , pp. 4855-4863
    • Chiari, R.1    Hames, G.2    Stroobant, V.3    Texier, C.4    Maillere, B.5    Boon, T.6    Coulie, P.G.7
  • 23
    • 0031946730 scopus 로고    scopus 로고
    • Overexpression of Lerk-5/Eplg5 messenger RNA: A novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas
    • Vogt, T., Stolz, W., Welsh, J., Jung, B., Kerbel, R. S., Kobayashi, H., Landthaler, M., and McClelland, M. (1998) Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas. Clin. Cancer Res. 4, 791-797.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 791-797
    • Vogt, T.1    Stolz, W.2    Welsh, J.3    Jung, B.4    Kerbel, R.S.5    Kobayashi, H.6    Landthaler, M.7    McClelland, M.8
  • 25
    • 0037378465 scopus 로고    scopus 로고
    • Differential regulation of EphA2 in normal and malignant cells
    • Walker-Daniels, J., Hess, A. R., Hendrix, M. J., and Kinch, M. S. (2003) Differential regulation of EphA2 in normal and malignant cells. Am. J. Pathol. 162, 1037-1042.
    • (2003) Am. J. Pathol. , vol.162 , pp. 1037-1042
    • Walker-Daniels, J.1    Hess, A.R.2    Hendrix, M.J.3    Kinch, M.S.4
  • 26
    • 0028345221 scopus 로고
    • Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis
    • Andres, A. C., Reid, H. H., Zurcher, G., Blaschke, R. J., Albrecht, D., and Ziemiecki, A. (1994) Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. Oncogene 9, 1461-1467.
    • (1994) Oncogene , vol.9 , pp. 1461-1467
    • Andres, A.C.1    Reid, H.H.2    Zurcher, G.3    Blaschke, R.J.4    Albrecht, D.5    Ziemiecki, A.6
  • 30
    • 4644307189 scopus 로고    scopus 로고
    • Expression of EphA2 and E-cadherin in colorectal cancer: Correlation with cancer metastasis
    • Saito, T., Masuda, N., Miyazaki, T., Kanoh, K., Suzuki, H., Shimura, T., Asao, T., and Kuwano, H. (2004) Expression of EphA2 and E-cadherin in colorectal cancer: correlation with cancer metastasis. Oncol. Rep. 11, 605-611.
    • (2004) Oncol. Rep. , vol.11 , pp. 605-611
    • Saito, T.1    Masuda, N.2    Miyazaki, T.3    Kanoh, K.4    Suzuki, H.5    Shimura, T.6    Asao, T.7    Kuwano, H.8
  • 31
    • 2342577589 scopus 로고    scopus 로고
    • The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells
    • Nakada, M., Niska, J. A., Miyamori, H., McDonough, W. S., Wu, J., Sato, H., and Berens, M. E. (2004) The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res. 64, 3179-3185.
    • (2004) Cancer Res. , vol.64 , pp. 3179-3185
    • Nakada, M.1    Niska, J.A.2    Miyamori, H.3    McDonough, W.S.4    Wu, J.5    Sato, H.6    Berens, M.E.7
  • 32
    • 0034619758 scopus 로고    scopus 로고
    • The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
    • Ogawa, K., Pasqualini, R., Lindberg, R. A., Kain, R., Freeman, A. L., and Pasquale, E. B. (2000) The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene 19, 6043-6052.
    • (2000) Oncogene , vol.19 , pp. 6043-6052
    • Ogawa, K.1    Pasqualini, R.2    Lindberg, R.A.3    Kain, R.4    Freeman, A.L.5    Pasquale, E.B.6
  • 37
    • 0036635253 scopus 로고    scopus 로고
    • Ephrins in reverse, park and drive
    • Cowan, C. A., and Henkemeyer, M. (2002) Ephrins in reverse, park and drive. Trends Cell Biol. 12, 339-346.
    • (2002) Trends Cell Biol. , vol.12 , pp. 339-346
    • Cowan, C.A.1    Henkemeyer, M.2
  • 38
    • 0242352659 scopus 로고    scopus 로고
    • Ephrin signalling: One raft to rule them all? One raft to sort them? One raft to spread their call and in signalling bind them?
    • Gauthier, L. R., and Robbins, S. M. (2003) Ephrin signalling: One raft to rule them all? One raft to sort them? One raft to spread their call and in signalling bind them? Life Sci. 74, 207-216.
    • (2003) Life Sci. , vol.74 , pp. 207-216
    • Gauthier, L.R.1    Robbins, S.M.2
  • 39
    • 1442358805 scopus 로고    scopus 로고
    • Recruitment of Eph receptors into signalling clusters does not require ephrin contact
    • Wimmer-Kleikamp, S. H., Janes, P. W., Squire, A., Bastiaens, P. I., and Lackmann, M. (2004) Recruitment of Eph receptors into signalling clusters does not require ephrin contact. J. Cell Biol. 164, 661-666.
    • (2004) J. Cell Biol. , vol.164 , pp. 661-666
    • Wimmer-Kleikamp, S.H.1    Janes, P.W.2    Squire, A.3    Bastiaens, P.I.4    Lackmann, M.5
  • 40
    • 0034130476 scopus 로고    scopus 로고
    • Control of cell behaviour by signalling through Eph receptors and ephrins
    • Mellitzer, G., Xu, Q., and Wilkinson, D. G. (2000) Control of cell behaviour by signalling through Eph receptors and ephrins. Curr. Opin. Neurobid. 10, 400-408.
    • (2000) Curr. Opin. Neurobid. , vol.10 , pp. 400-408
    • Mellitzer, G.1    Xu, Q.2    Wilkinson, D.G.3
  • 41
    • 0035846705 scopus 로고    scopus 로고
    • Signals from Eph and ephrin proteins: A developmental tool kit
    • Boyd, A. W., and Lackmann, M. (2001) Signals from Eph and ephrin proteins: a developmental tool kit. Sci. STKE, 2001, RE20.
    • (2001) Sci. STKE , vol.2001
    • Boyd, A.W.1    Lackmann, M.2
  • 42
    • 3042680296 scopus 로고    scopus 로고
    • Ephrin-B2 reverse signalling is required for axon pathfinding and cardiac valve formation but not early vascular development
    • Cowan, C. A., Yokoyama, N., Saxena, A., Chumley, M. J., Silvany, R. E., Baker, L. A., Srivastava, D., and Henkemeyer, M. (2004) Ephrin-B2 reverse signalling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev. Biol. 271, 263-271.
    • (2004) Dev. Biol. , vol.271 , pp. 263-271
    • Cowan, C.A.1    Yokoyama, N.2    Saxena, A.3    Chumley, M.J.4    Silvany, R.E.5    Baker, L.A.6    Srivastava, D.7    Henkemeyer, M.8
  • 44
    • 0141839883 scopus 로고    scopus 로고
    • EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion
    • Zimmer, M., Palmer, A., Kohler, J., and Klein, R. (2003) EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat. Cell Biol. 5, 869-878.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 869-878
    • Zimmer, M.1    Palmer, A.2    Kohler, J.3    Klein, R.4
  • 45
    • 0141839882 scopus 로고    scopus 로고
    • Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion
    • Marston, D. J., Dickinson, S., and Nobes, C. D. (2003) Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion. Nat. Cell Biol. 5, 879-888.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 879-888
    • Marston, D.J.1    Dickinson, S.2    Nobes, C.D.3
  • 46
    • 0034714357 scopus 로고    scopus 로고
    • Regulated cleavage of a contact-mediated axon repellent
    • Hattori, M., Osterfield, M., and Flanagan, J. G. (2000) Regulated cleavage of a contact-mediated axon repellent. Science 289, 1360-1365.
    • (2000) Science , vol.289 , pp. 1360-1365
    • Hattori, M.1    Osterfield, M.2    Flanagan, J.G.3
  • 47
    • 0036568740 scopus 로고    scopus 로고
    • Ephrins are not only unattractive
    • Holmberg, J., and Frisen, J. (2002) Ephrins are not only unattractive. Trends Neurosci. 25, 239-243.
    • (2002) Trends Neurosci. , vol.25 , pp. 239-243
    • Holmberg, J.1    Frisen, J.2
  • 48
    • 0033560751 scopus 로고    scopus 로고
    • Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins
    • Huynh-Do, U., Stein, E., Lane, A. A., Liu, H., Cerretti, D. P., and Daniel, T. O. (1999) Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins. EMBO J. 18, 2165-2173.
    • (1999) EMBO J. , vol.18 , pp. 2165-2173
    • Huynh-Do, U.1    Stein, E.2    Lane, A.A.3    Liu, H.4    Cerretti, D.P.5    Daniel, T.O.6
  • 49
    • 0034676025 scopus 로고    scopus 로고
    • Ephrin-A5 modulates cell adhesion and morphology in an integrin- Dependent manner
    • Davy, A., and Robbins, S. M. (2000) Ephrin-A5 modulates cell adhesion and morphology in an integrin- dependent manner. EMBO J. 19, 5396-5405.
    • (2000) EMBO J. , vol.19 , pp. 5396-5405
    • Davy, A.1    Robbins, S.M.2
  • 50
  • 51
    • 0033785409 scopus 로고    scopus 로고
    • Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
    • Miao, H., Burnett, E., Kinch, M., Simon, E., and Wang, B. (2000) Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2, 62-69.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 62-69
    • Miao, H.1    Burnett, E.2    Kinch, M.3    Simon, E.4    Wang, B.5
  • 52
    • 0036045804 scopus 로고    scopus 로고
    • EphrinA 1-induced cytoskeletal re-organization requires FAK and p130(cas)
    • Carter, N., Nakamoto, T., Hirai, H., and Hunter, T. (2002) EphrinA 1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat. Cell Biol. 4, 565-573.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 565-573
    • Carter, N.1    Nakamoto, T.2    Hirai, H.3    Hunter, T.4
  • 53
    • 0242456170 scopus 로고    scopus 로고
    • Axis of evil: Molecular mechanisms of cancer metastasis
    • Bogenrieder, T., and Herlyn, M. (2003) Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 22, 6524-6536.
    • (2003) Oncogene , vol.22 , pp. 6524-6536
    • Bogenrieder, T.1    Herlyn, M.2
  • 54
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: Diversity and escape mechanisms
    • Friedl, P., and Wolf, K. (2003) Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3, 362-374.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 55
    • 1842828975 scopus 로고    scopus 로고
    • Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins
    • Noren, N. K., and Pasquale, E. B. (2004) Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins. Cell Signal. 16, 655-666.
    • (2004) Cell Signal. , vol.16 , pp. 655-666
    • Noren, N.K.1    Pasquale, E.B.2
  • 56
    • 0032031705 scopus 로고    scopus 로고
    • Eph receptors discriminate specific ligand oligomers to determine alternative signalling complexes, attachment, and assembly responses
    • Stein, E., Lane, A. A., Cerretti, D. P., Schoecklmann, H. O., Schroff, A. D., Van Etten, R. L., and Daniel, T. O. (1998) Eph receptors discriminate specific ligand oligomers to determine alternative signalling complexes, attachment, and assembly responses. Genes Dev. 12, 667-678.
    • (1998) Genes Dev. , vol.12 , pp. 667-678
    • Stein, E.1    Lane, A.A.2    Cerretti, D.P.3    Schoecklmann, H.O.4    Schroff, A.D.5    Van Etten, R.L.6    Daniel, T.O.7
  • 57
    • 0036500192 scopus 로고    scopus 로고
    • Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3- Expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
    • Lawrenson, I. D., Wimmer-Kleikamp, S. H., Lock, P., Schoenwaelder, S. M., Down, M., Boyd, A. W., Alewood, P. F., and Lackmann, M. (2002) Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3- expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. J. Cell Sci. 115, 1059-1072.
    • (2002) J. Cell Sci. , vol.115 , pp. 1059-1072
    • Lawrenson, I.D.1    Wimmer-Kleikamp, S.H.2    Lock, P.3    Schoenwaelder, S.M.4    Down, M.5    Boyd, A.W.6    Alewood, P.F.7    Lackmann, M.8
  • 58
    • 0034960682 scopus 로고    scopus 로고
    • The EphAS receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner
    • Gu, C., and Park, S. (2001) The EphAS receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner. Mol. Cell Biol. 21, 4579-4597.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 4579-4597
    • Gu, C.1    Park, S.2
  • 59
    • 0037127210 scopus 로고    scopus 로고
    • Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity
    • Zou, J. X., Liu, Y., Pasquale, E. B., and Ruoslahti, E. (2002) Activated SRC oncogene phosphorylates R-ras and suppresses integrin activity. J. Biol. Chem. 277, 1824-1827.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1824-1827
    • Zou, J.X.1    Liu, Y.2    Pasquale, E.B.3    Ruoslahti, E.4
  • 60
    • 12544252826 scopus 로고    scopus 로고
    • Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase: Role of Rho family small GTPases
    • Miao, H., Strebhardt, K., Pasquale, E. B., Shen, T. L., Guan, J. L., and Wang, B. (2004) Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase: Role of Rho family small GTPases. J. Biol. Chem. 280, 923-32.
    • (2004) J. Biol. Chem. , vol.280 , pp. 923-932
    • Miao, H.1    Strebhardt, K.2    Pasquale, E.B.3    Shen, T.L.4    Guan, J.L.5    Wang, B.6
  • 61
    • 0034072748 scopus 로고    scopus 로고
    • Expression of Eph receptors and ephrins is differentially regulated by E-cadherin
    • Orsulic, S., and Kemler, R. (2000) Expression of Eph receptors and ephrins is differentially regulated by E-cadherin. J. Cell Sci. 113, 1793-1802.
    • (2000) J. Cell Sci. , vol.113 , pp. 1793-1802
    • Orsulic, S.1    Kemler, R.2
  • 62
    • 0038457473 scopus 로고    scopus 로고
    • Molecular plasticity of human melanoma cells
    • Hendrix, M. J., Seftor, E. A., Hess, A. R., and Seftor, R. E. (2003) Molecular plasticity of human melanoma cells. Oncogene 22, 3070-3075.
    • (2003) Oncogene , vol.22 , pp. 3070-3075
    • Hendrix, M.J.1    Seftor, E.A.2    Hess, A.R.3    Seftor, R.E.4
  • 63
    • 0037168958 scopus 로고    scopus 로고
    • Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells
    • Potla, L., Boghaert, E. R., Armellino, D., Frost, P., and Damle, N. K. (2002) Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells. Cancer Lett. 175, 187-195.
    • (2002) Cancer Lett. , vol.175 , pp. 187-195
    • Potla, L.1    Boghaert, E.R.2    Armellino, D.3    Frost, P.4    Damle, N.K.5
  • 64
    • 0037980379 scopus 로고    scopus 로고
    • Metastasis suppressor pathways - An evolving paradigm
    • Shevde, L. A., and Welch, D. R. (2003) Metastasis suppressor pathways - an evolving paradigm. Cancer Lett. 198, 1-20.
    • (2003) Cancer Lett. , vol.198 , pp. 1-20
    • Shevde, L.A.1    Welch, D.R.2
  • 65
    • 1842732148 scopus 로고    scopus 로고
    • Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth
    • Noren, N. K., Lu, M., Freeman, A. L., Koolpe, M., and Pasquale, E. B. (2004) Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proc. Natl. Acad. Sci. USA 101, 5583-5588.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5583-5588
    • Noren, N.K.1    Lu, M.2    Freeman, A.L.3    Koolpe, M.4    Pasquale, E.B.5
  • 66
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville, S., and Hall, A. (2002) Rho GTPases in cell biology. Nature 420, 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 68
    • 0036911338 scopus 로고    scopus 로고
    • Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells
    • Nagashima, K., Endo, A., Ogita, H., Kawana, A., Yamagishi, A., Kitabatake, A., Matsuda, M., and Mochizuki, N. (2002) Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol. Biol. Cell 13, 4231-4242.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 4231-4242
    • Nagashima, K.1    Endo, A.2    Ogita, H.3    Kawana, A.4    Yamagishi, A.5    Kitabatake, A.6    Matsuda, M.7    Mochizuki, N.8
  • 69
    • 0034790653 scopus 로고    scopus 로고
    • Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction
    • Elowe, S., Holland, S. J., Kulkarni, S., and Pawson, T. (2001) Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction. Mol. Cell Biol. 21, 7429-7441.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 7429-7441
    • Elowe, S.1    Holland, S.J.2    Kulkarni, S.3    Pawson, T.4
  • 70
    • 0037458569 scopus 로고    scopus 로고
    • Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signalling and biological activity
    • Tong, J., Elowe, S., Nash, P., and Pawson, T. (2003) Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signalling and biological activity. J. Biol. Chem. 278, 6111-6119.
    • (2003) J. Biol. Chem. , vol.278 , pp. 6111-6119
    • Tong, J.1    Elowe, S.2    Nash, P.3    Pawson, T.4
  • 71
    • 0031001812 scopus 로고    scopus 로고
    • Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
    • Holland, S. J., Gale, N. W., Gish, G. D., Roth, R. A., Songyang, Z., Cantley, L. C., Henkemeyer, M., Yancopoulos, G. D., and Pawson, T. (1997) Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J. 16, 3877-3888.
    • (1997) EMBO J. , vol.16 , pp. 3877-3888
    • Holland, S.J.1    Gale, N.W.2    Gish, G.D.3    Roth, R.A.4    Songyang, Z.5    Cantley, L.C.6    Henkemeyer, M.7    Yancopoulos, G.D.8    Pawson, T.9
  • 74
    • 0345169031 scopus 로고    scopus 로고
    • Lateral phosphorylation propagation: An aspect of feedback signalling?
    • Tischer, C. and Bastiens, P. I. (2003) Lateral phosphorylation propagation: an aspect of feedback signalling? Nat. Rev. Mol. Cell Biol. 4, 971-974.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 971-974
    • Tischer, C.1    Bastiens, P.I.2
  • 75
    • 0035421804 scopus 로고    scopus 로고
    • Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells
    • Luo, H., Wan, X., Wu, Y., and Wu, J. (2001) Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. J. Immunol. 167, 1362-1370.
    • (2001) J. Immunol. , vol.167 , pp. 1362-1370
    • Luo, H.1    Wan, X.2    Wu, Y.3    Wu, J.4
  • 76
    • 0037131355 scopus 로고    scopus 로고
    • Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation
    • Kikawa, K. D., Vidale, D. R., Van Etten, R. L., and Kinch, M. S. (2002) Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. J. Biol. Chem. 277, 39274-39279.
    • (2002) J. Biol. Chem. , vol.277 , pp. 39274-39279
    • Kikawa, K.D.1    Vidale, D.R.2    Van Etten, R.L.3    Kinch, M.S.4
  • 78
    • 0038119084 scopus 로고    scopus 로고
    • The EphAS receptor phosphorylates and activates low molecular weight phosphotyrosine protein phosphatase in vitro
    • Park, S. (2003) The EphAS receptor phosphorylates and activates low molecular weight phosphotyrosine protein phosphatase in vitro. J. Biochem. Mol. Biol. 36, 288-293.
    • (2003) J. Biochem. Mol. Biol. , vol.36 , pp. 288-293
    • Park, S.1
  • 87


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