P2X receptors: Targets for novel analgesics?

Neuroscientist

Volumn 11, Issue 4, 2005, Pages 345-356

  Kennedy, Charles ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

P2X receptors; P2Y receptors; Pain

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; A 317491; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; IP 51; MESSENGER RNA; PURINE P2X RECEPTOR; PURINERGIC RECEPTOR AFFECTING AGENT; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; SURAMIN; UNCLASSIFIED DRUG;

ANALGESIA; CHRONIC PAIN; CONCENTRATION RESPONSE; DRUG TARGETING; NEUROPHARMACOLOGY; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RECEPTOR BLOCKING; REVIEW; SENSORY NERVE;

ADENOSINE TRIPHOSPHATE; ANALGESICS; ANIMALS; GENE EXPRESSION REGULATION; HUMANS; MODELS, BIOLOGICAL; NEURONS, AFFERENT; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PAIN; PAIN MEASUREMENT; RECEPTORS, PURINERGIC P2;

EID: 22844436446     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/1073858404274063     Document Type: Review

References (60)

1. 3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci 22:8139-47.
2. Barden JA, Bennett MR. 2000. Distribution of P2X purinoceptor clusters on individual rat dorsal root ganglion cells. Neurosci Lett 287:183-6.
3. 3 purinoceptor in sensory neurones: effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci 12:256-68.
4. 12 receptors show a novel sensitivity to extracellular pH. J Pharmacol Exp Ther 300:673-80.
5. Burgard EC, Niforatos W, Van Biesen T, Lynch KJ, Tourna E, Metzger RE, and others. 1999. P2X receptor-mediated ionic currents in dorsal root ganglion neurones. J Neurophysiol 82:1590-8.
6. Burnstock G. 2001. Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 22:182-7.
7. Burnstock G, Kennedy C. 1985. Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol 16:433-40.
8. Burnstock G, Wood JN. 1996. Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr Op Neurobiol 6:526-32.
9. Caterina MJ, Julius D. 1999. Sense and specificity: a molecular identity for nociceptors. Curr Opin Neurobiol 9:525-30.
10. Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN. 1995. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377:428-31.
11. Chizh BA, Illes P. 2000. P2X receptors and nociception. Pharm Rev 53:553-68.
12. 3-deficient mice. Nature 407:1011-15.
13. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16:2495-507.
14. Cook SP, McCleskey EW. 2002. Cell damage excites nociceptors through release of cytosolic ATP. Pain 95:41-7.
15. Dorn G, Patel S, Wotherspoon G, Hemmings-Mieszczak M, Barclay J, Natt FJC, and others. 2004. siRNA relieves chronic neuropathic pain. Nucleic Acid Res 32:e49.
16. Egan TM, Khakh B. 2004. Contribution of calcium ions to P2X channel responses. J Neurosci 24:3413-20.
17. 3 receptors in the rat trigeminal ganglion after inferior alveolar nerve injury. Neurosci Lett 254:37-40.
18. Grubb BD, Evans RJ. 1999. Characterization of cultured dorsal root ganglion neuron P2X receptors. Eur J Neurosci 11:149-54.
19. Hamilton SG, McMahon SB, Lewin GR. 2001. Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin. J Physiol 534:437-45.
20. Holton P. 1959. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol 145:494-504.
21. 3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain 99:11-19.
22. 2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A 99:17179-84.
23. 4 receptor orthologues. Br J Pharmacol 129:388-94.
24. 6 receptors by N-linked glycosylation: identification of a novel αβ-methyleneATP-sensitive phenotype. Mol Pharmacol 65:979-85.
25. 3 receptor expression and function following spinal nerve ligation in the rat. Exp Brain Res 147:511-19.
26. 2-purinoceptor subtypes-an update. Arch Int Pharmacodynam 303:30-50.
27. Kennedy C, Assis TS, Currie A, Rowan EG. 2003. Crossing the pain barrier: P2 receptors as targets for novel analgesics. J Physiol 553:683-94.
28. Kennedy C, Leff P. 1995a. How should P2X-purinoceptors be characterised pharmacologically? Trends Pharmacol Sci 16:168-74.
29. Kennedy C, Leff P. 1995b. Painful connection for ATP. Nature 377:285-386.
30. Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Seguela P, and others. 2001. International Union of Pharmacology XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev 53:107-18.
31. Lawson SN. 1992. Morphological and biochemical cell types of sensory neurons. In: Scott SA, editor. Sensory neurons: diversity, development and plasticity. New York: Oxford University Press. p 27-59.
32. 3 receptor subunits can account for ATP currents in sensory neurons. Nature 377:432-5.
33. Li C, Peoples RW, Lanthorn TH, Li ZW, Weight FF. 1999. Distinct ATP-activated currents in different types of neurons dissociated from rat dorsal root ganglion. Neurosci Lett 263:57-60.
34. 3 receptors in rat sensory neurons. Neuroreport 9:2545-50.
35. Millan MJ. 1999. The induction of pain: an integrative review. Prog Neurobiol 57:1-164.
36. Nakatsuka T, Gu JG. 2001. ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord. J Neurosci 21:6522-31.
37. Nakatsuka T, Tsuzuki K, Ling JX, Sonobe H, Gu JG. 2003. Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord. J Neurophysiol 89:3243-3252.
38. North RA. 2002. Molecular physiology of P2X receptors. Physiol Rev 82:1013-67.
39. 3 purinoceptors in sensory neurons in naïve rats and following neuropathic injury. Pain 80:273-82.
40. Okada M, Nakagawa T, Minami M, Satoh M. 2002. Analgesic effects of intrathecal administration of P2Y nuclcotide receptor agonists UTP and UDP in normal and neuropathic pain model rats. J Pharmacol Exp Ther 303:66-73.
41. 3 subunit. J Biol Chem 276:21077-82.
42. Perl ER. 1992. Function of dorsal root ganglion neurons: an overview. In: Scott SA, editor. Sensory neurons: diversity, development and plasticity. New York: Oxford University Press. p 3-23.
43. 3 receptor subunits in rat primary afferents: relation to population markers and specific cell types. J Chem Neuroanat 20:141-62.
44. Petruska JC, Napaporn J, Johnson RD, Gu JG, Cooper BY. 2000b. Subclassified acutely dissociated cells of rat DRG: histochemistry and patterns of capsaicin-, proton-, and ATP-activated currents. J Neurophysiol 84:2365-79.
45. 3 receptors present in neurones of the rat dorsal root ganglia. Br J Pharmacol 124:176-80.
46. Robertson SJ, Rae MG, Rowan EG, Kennedy C. 1996. Characterization of a P2X-purinoccptor in cultured neurones of the rat dorsal root ganglia. Br J Pharmacol 118:951-6.
47. Snider WD, McMahon SB. 1998. Tackling pain at the source: new ideas about nociceptors. Neuron 20:629-32.
48. 3 receptors. Nature 407:1015-17.
49. Torres GE, Egan TM, Voigt MM. 1999. Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners. J Biol Chem 274:6653-9.
50. Tsuzuki K, Ase A, Séguéla P, Nakatsuka T, Wang CY, She JX, Gu JG. 2003. TNP-ATP-resistant P2X ionic currents on the central terminals and somata of rat primary sensory neurons. J Neurophysiol 89:3235-42.
51. 3 mRNA regulation by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia. Pain 91:351-60.
52. Ueno S, Tsuda M, Iwanaga T, Inoue K. 1999. Cell type-specific ATP-activated responses in rat dorsal root. Br J Pharmacol 126:429-36.
53. 3 receptor localizes into lipid rafts in neuronal cells. J Neurosci Res 76:653-61.
54. Vial C, Roberts JA, Evans RJ. 2004. Molecular properties of ATP-gated P2X receptor ion channels. Trends Pharmacol Sci 25:487-93.
55. 3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci 10:3470-8.
56. Wismer CT, Faltynek CR, Jarvis MF, McGaraughty S. 2003. Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists in the hind paw of a rat. Brain Res 965:187-93.
57. Woolf CJ, Salter MW. 2000. Neuronal plasticity: increasing the gain in pain. Science 288:1765-8.
58. 2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats. Eur J Pharmacol 504:45-53.
59. Xiang Z, Bo X, Burnstock G. 1998. Localisation of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia. Neurosci Lett 256:105-8.
60. 3 receptor in injured human sensory neurons. Neuroreport 11:993-6.