-
1
-
-
0033856462
-
PI3-kinase inhibition: A target for drug development?
-
Stein RC, Waterfield MD. PI3-kinase inhibition: A target for drug development? Mol Med Today 2000; 6:347-57.
-
(2000)
Mol Med Today
, vol.6
, pp. 347-357
-
-
Stein, R.C.1
Waterfield, M.D.2
-
2
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
-
Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001; 17:615-75.
-
(2001)
Annu Rev Cell Dev Biol
, vol.17
, pp. 615-675
-
-
Katso, R.1
Okkenhaug, K.2
Ahmadi, K.3
White, S.4
Timms, J.5
Waterfield, M.D.6
-
3
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
4
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296:1655-7.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
5
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Gray JW. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999; 21:99-102.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
Pinkel, D.7
Powell, B.8
Mills, G.B.9
Gray, J.W.10
-
6
-
-
0041672301
-
The oncogene phosphatidylinositol 3′-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma
-
Zhang L, Yang N, Katsaros D, Huang W, Park JW, Fracchioli S, Vezzani C, Rigault de la Longrais LA, Yao W, Rubin SC, Coukos G. The oncogene phosphatidylinositol 3′-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma. Cancer Res 2003; 63:4225-31.
-
(2003)
Cancer Res
, vol.63
, pp. 4225-4231
-
-
Zhang, L.1
Yang, N.2
Katsaros, D.3
Huang, W.4
Park, J.W.5
Fracchioli, S.6
Vezzani, C.7
Rigault De La Longrais, L.A.8
Yao, W.9
Rubin, S.C.10
Coukos, G.11
-
7
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
Campbell IG, Russell SE, Choong DYH, Montgomery KG, Ciavarella ML, Hooi CSF, Cristiano BE, Pearson RB, Phillips WE. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Research 2004; 64:7678-81.
-
(2004)
Cancer Research
, vol.64
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.H.3
Montgomery, K.G.4
Ciavarella, M.L.5
Hooi, C.S.F.6
Cristiano, B.E.7
Pearson, R.B.8
Phillips, W.E.9
-
8
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
In press
-
Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, Peters BA, Velculescu VE, Park BH. The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 2004; In press.
-
(2004)
Cancer Biol Ther
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Konishi, H.7
Karakas, B.8
Blair, B.G.9
Lin, C.10
Peters, B.A.11
Velculescu, V.E.12
Park, B.H.13
-
9
-
-
3442878125
-
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas
-
Broderick DK, Di C, Parrett TJ, Samuels YR, Cummins JM, McLendon RE, Fults DW, Velculescu VE, Bigner DD, Yan H. Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Res 2004; 64:5048-50.
-
(2004)
Cancer Res
, vol.64
, pp. 5048-5050
-
-
Broderick, D.K.1
Di, C.2
Parrett, T.J.3
Samuels, Y.R.4
Cummins, J.M.5
McLendon, R.E.6
Fults, D.W.7
Velculescu, V.E.8
Bigner, D.D.9
Yan, H.10
-
10
-
-
0036351317
-
Analysis of gene function in somatic mammalian cells using small interfering RNAs
-
Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 2002; 26:199-213.
-
(2002)
Methods
, vol.26
, pp. 199-213
-
-
Elbashir, S.M.1
Harborth, J.2
Weber, K.3
Tuschl, T.4
-
11
-
-
0036788304
-
Gene silencing in mammals by small interfering RNAs
-
McManus MT, Sharp PA. Gene silencing in mammals by small interfering RNAs. Nat Rev Genet 2002; 3:737-47.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 737-747
-
-
McManus, M.T.1
Sharp, P.A.2
-
12
-
-
0037062951
-
RNA interference
-
Hannon GJ. RNA interference. Nature 2002; 418:244-51.
-
(2002)
Nature
, vol.418
, pp. 244-251
-
-
Hannon, G.J.1
-
13
-
-
0037213559
-
Mammalian RNAi for the masses
-
Shi Y. Mammalian RNAi for the masses. Trends Genet 2003; 19:9-12.
-
(2003)
Trends Genet
, vol.19
, pp. 9-12
-
-
Shi, Y.1
-
14
-
-
0036066508
-
siRNA-directed inhibition of HIV-1 infection
-
Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK, Collman RG, Lieberman J, Shankar P, Sharp PA. siRNA-directed inhibition of HIV-1 infection. Nat Med 2002; 8:081-6.
-
(2002)
Nat Med
, vol.8
, pp. 81-86
-
-
Novina, C.D.1
Murray, M.F.2
Dykxhoorn, D.M.3
Beresford, P.J.4
Riess, J.5
Lee, S.K.6
Collman, R.G.7
Lieberman, J.8
Shankar, P.9
Sharp, P.A.10
-
15
-
-
0036726313
-
Stable suppression of tumorigenicity by virus-mediated RNA interference
-
Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002; 2:243-7.
-
(2002)
Cancer Cell
, vol.2
, pp. 243-247
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
16
-
-
0037197914
-
RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
-
USA
-
Yu JY, DeRuiter SL, Turner DL. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci USA 2002; 99:6047-52.
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 6047-6052
-
-
Yu, J.Y.1
DeRuiter, S.L.2
Turner, D.L.3
-
17
-
-
0037117550
-
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
-
USA
-
Sui G, Soohoo C, Affar el B, Gay F, Shi Y, Forrester WC. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA 2002; 99:5515-20.
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 5515-5520
-
-
Sui, G.1
Soohoo, C.2
El Affar, B.3
Gay, F.4
Shi, Y.5
Forrester, W.C.6
-
18
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002; 296:550-3.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
19
-
-
0037089589
-
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
-
Paddison PJ, Gaudy AA, Bernstein E, Hannon GJ, Conklin DS. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev 2002; 16:948-58.
-
(2002)
Genes Dev
, vol.16
, pp. 948-958
-
-
Paddison, P.J.1
Gaudy, A.A.2
Bernstein, E.3
Hannon, G.J.4
Conklin, D.S.5
-
21
-
-
0036245628
-
U6 promoter driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells
-
Miyagishi M, Taira K. U6 promoter driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol 2002; 20:497-500.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 497-500
-
-
Miyagishi, M.1
Taira, K.2
-
22
-
-
0036256430
-
Expression of small interfering RNAs targeted against HlV-1 rev transcripts in human cells
-
Lee NS, Dohjima T, Bauer G, Li H, Li MJ, Ehsani A, Salvaterra P, Rossi J. Expression of small interfering RNAs targeted against HlV-1 rev transcripts in human cells. Nat Biotechnol 2002; 20:500-5.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 500-505
-
-
Lee, N.S.1
Dohjima, T.2
Bauer, G.3
Li, H.4
Li, M.J.5
Ehsani, A.6
Salvaterra, P.7
Rossi, J.8
-
23
-
-
0036294527
-
Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
-
Zeng Y, Wagner EJ, Cullen BR. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol Cell 2002; 9:1327-33.
-
(2002)
Mol Cell
, vol.9
, pp. 1327-1333
-
-
Zeng, Y.1
Wagner, E.J.2
Cullen, B.R.3
-
24
-
-
0036273940
-
Gene silencing using micro-RNA designed hairpins
-
McManus MT, Petersen CP, Haines BB, Chen J, Sharp PA. Gene silencing using micro-RNA designed hairpins. Rna 2002; 8:842-50.
-
(2002)
Rna
, vol.8
, pp. 842-850
-
-
McManus, M.T.1
Petersen, C.P.2
Haines, B.B.3
Chen, J.4
Sharp, P.A.5
-
25
-
-
0642303887
-
Inducible shRNA expression for application in a prostate cancer mouse model
-
Czauderna F, Santel A, Hinz M, Fechtner M, Durieux B, Fisch G, Leenders F, Arnold W, Giese K, Klippel A, Kaufmann J. Inducible shRNA expression for application in a prostate cancer mouse model. Nucleic Acids Res 2003; 31:e127.
-
(2003)
Nucleic Acids Res
, vol.31
-
-
Czauderna, F.1
Santel, A.2
Hinz, M.3
Fechtner, M.4
Durieux, B.5
Fisch, G.6
Leenders, F.7
Arnold, W.8
Giese, K.9
Klippel, A.10
Kaufmann, J.11
-
26
-
-
0037440004
-
Functional studies of the PI3-kinase signalling pathway employing synthetic and expressed siRNA
-
Czauderna F, Fechtner M, Aygun H, Arnold W, Klippel A, Giese K, Kaufmann J. Functional studies of the PI3-kinase signalling pathway employing synthetic and expressed siRNA. Nucleic Acids Res 2003; 31:670-82.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 670-682
-
-
Czauderna, F.1
Fechtner, M.2
Aygun, H.3
Arnold, W.4
Klippel, A.5
Giese, K.6
Kaufmann, J.7
-
27
-
-
0036297353
-
Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in marine ovarian cancer cells
-
Zhang L, Conejo-Garcia JR, Yang N, Huang W, Mohamed-Hadley A, Yao W, Benencia F, Coukos G. Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in marine ovarian cancer cells. Biochem Biophys Res Commun 2002; 292:860-8.
-
(2002)
Biochem Biophys Res Commun
, vol.292
, pp. 860-868
-
-
Zhang, L.1
Conejo-Garcia, J.R.2
Yang, N.3
Huang, W.4
Mohamed-Hadley, A.5
Yao, W.6
Benencia, F.7
Coukos, G.8
-
28
-
-
12244291903
-
Expression of endocrine gland-derived vascular endothelial growth factor in ovarian carcinoma
-
Zhang L, Yang N, Conejo-Garcia JR, Katsaros D, Mohamed-Hadley A, Fracchioli S, Schlienger K, Toll A, Levine B, Rubin SC, Coukos G. Expression of endocrine gland-derived vascular endothelial growth factor in ovarian carcinoma. Clin Cancer Res 2003; 9:264-72.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 264-272
-
-
Zhang, L.1
Yang, N.2
Conejo-Garcia, J.R.3
Katsaros, D.4
Mohamed-Hadley, A.5
Fracchioli, S.6
Schlienger, K.7
Toll, A.8
Levine, B.9
Rubin, S.C.10
Coukos, G.11
-
29
-
-
0036899148
-
Generation of a syngeneic mouse model to study the effects of vascular endothelial growth factor in ovarian carcinoma
-
Zhang L, Yang N, Garcia JR, Mohamed A, Benencia F, Rubin SC, Allman D, Coukos G. Generation of a syngeneic mouse model to study the effects of vascular endothelial growth factor in ovarian carcinoma. Am J Pathol 2002; 161:2295-309.
-
(2002)
Am J Pathol
, vol.161
, pp. 2295-2309
-
-
Zhang, L.1
Yang, N.2
Garcia, J.R.3
Mohamed, A.4
Benencia, F.5
Rubin, S.C.6
Allman, D.7
Coukos, G.8
-
30
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411:494-8.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
31
-
-
0036245743
-
Expanding small RNA interference
-
Tuschl T. Expanding small RNA interference. Nat Biotechnol 2002; 20:446-8.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 446-448
-
-
Tuschl, T.1
-
32
-
-
0029949294
-
Retroviral vectors designed for targeted expression of RNA polymerase III-driven transcripts: A comparative study
-
Ilves H, Barske C, Junker U, Bohnlein E, Veres G. Retroviral vectors designed for targeted expression of RNA polymerase III-driven transcripts: A comparative study. Gene 1996; 171:203-8.
-
(1996)
Gene
, vol.171
, pp. 203-208
-
-
Ilves, H.1
Barske, C.2
Junker, U.3
Bohnlein, E.4
Veres, G.5
-
33
-
-
0037021437
-
Small interfering RNA and gene silencing in transgenic mice and rats
-
Hasuwa H, Kaseda K, Einarsdottir T, Okabe M. Small interfering RNA and gene silencing in transgenic mice and rats. FEBS Lett 2002; 532:227-30.
-
(2002)
FEBS Lett
, vol.532
, pp. 227-230
-
-
Hasuwa, H.1
Kaseda, K.2
Einarsdottir, T.3
Okabe, M.4
-
34
-
-
0037422583
-
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
-
USA
-
Qin XF, An DS, Chen IS, Baltimore D. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci USA 2003; 100:183-8.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 183-188
-
-
Qin, X.F.1
An, D.S.2
Chen, I.S.3
Baltimore, D.4
-
35
-
-
0037452812
-
A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA
-
USA
-
Tiscornia G, Singer O, Ikawa M, Verma IM. A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci USA 2003; 100:1844-8.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 1844-1848
-
-
Tiscornia, G.1
Singer, O.2
Ikawa, M.3
Verma, I.M.4
-
36
-
-
0036811055
-
Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3′-ends of siRNAs
-
Hamada M, Ohtsuka T, Kawaida R, Koizumi M, Morita K, Furukawa H, Imanishi T, Miyagishi M, Taira K. Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3′-ends of siRNAs. Antisense Nucleic Acid Drug Dev 2002; 12:301-9.
-
(2002)
Antisense Nucleic Acid Drug Dev
, vol.12
, pp. 301-309
-
-
Hamada, M.1
Ohtsuka, T.2
Kawaida, R.3
Koizumi, M.4
Morita, K.5
Furukawa, H.6
Imanishi, T.7
Miyagishi, M.8
Taira, K.9
-
38
-
-
19444386359
-
Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo
-
Gou D, Narasaraju T, Chintagari NR, Jin N, Wang P, Liu L. Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo. Nucleic Acids Res 2004; 32:e134.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Gou, D.1
Narasaraju, T.2
Chintagari, N.R.3
Jin, N.4
Wang, P.5
Liu, L.6
-
39
-
-
0029119992
-
Retroviral-like sequences specifically expressed in the rat ovary detect genetic differences between normal and transformed rat ovarian surface epithelial cells
-
Godwin AK, Miller PD, Getts LA, Jackson K, Sonoda G, Schray KJ, Testa JR, Hamilton TC. Retroviral-like sequences specifically expressed in the rat ovary detect genetic differences between normal and transformed rat ovarian surface epithelial cells. Endocrinology 1995; 136:4640-9.
-
(1995)
Endocrinology
, vol.136
, pp. 4640-4649
-
-
Godwin, A.K.1
Miller, P.D.2
Getts, L.A.3
Jackson, K.4
Sonoda, G.5
Schray, K.J.6
Testa, J.R.7
Hamilton, T.C.8
-
40
-
-
0037012343
-
Activation of cancer-specific gene expression by the survivin promoter
-
Bao R, Connolly DC, Murphy M, Green J, Weinstein JK, Pisarcik DA, Hamilton TC. Activation of cancer-specific gene expression by the survivin promoter. J Natl Cancer Inst 2002; 94:522-8.
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 522-528
-
-
Bao, R.1
Connolly, D.C.2
Murphy, M.3
Green, J.4
Weinstein, J.K.5
Pisarcik, D.A.6
Hamilton, T.C.7
-
41
-
-
0037444396
-
Female mice chimeric for expression of the simian virus 40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer
-
Connolly DC, Bao R, Nikitin AY, Stephens KC, Poole TW, Hua X, Harris SS, Vanderhyden BC, Hamilton TC. Female mice chimeric for expression of the simian virus 40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer. Cancer Res 2003; 63:1389-97.
-
(2003)
Cancer Res
, vol.63
, pp. 1389-1397
-
-
Connolly, D.C.1
Bao, R.2
Nikitin, A.Y.3
Stephens, K.C.4
Poole, T.W.5
Hua, X.6
Harris, S.S.7
Vanderhyden, B.C.8
Hamilton, T.C.9
|