-
4
-
-
0344412889
-
Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization
-
Biebermann H, Krude H, Elsner A, Chubanov V, Gudermann T, Gruters A. Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization. Diabetes 2003; 52: 2984-2988
-
(2003)
Diabetes
, vol.52
, pp. 2984-2988
-
-
Biebermann, H.1
Krude, H.2
Elsner, A.3
Chubanov, V.4
Gudermann, T.5
Gruters, A.6
-
5
-
-
0008075191
-
Plasma leptin levels in healthy children and adolescents. Dependence on body mass index, body fat mass, gender, pubertal stage and testosterone
-
Blum WF, Englaro P, Hanitsch S et al. Plasma leptin levels in healthy children and adolescents. Dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 1997; 822: 904-910
-
(1997)
J Clin Endocrinol Metab
, vol.822
, pp. 904-910
-
-
Blum, W.F.1
Englaro, P.2
Hanitsch, S.3
-
7
-
-
0030833768
-
Fat as a risk for overconsumption: Satiation, satiety, and patterns of eating
-
Blundell JE, Mac Diarmid JI. Fat as a risk for overconsumption: satiation, satiety, and patterns of eating. J Am Diet Assoc 1997; 97: S63-S69
-
(1997)
J Am Diet Assoc
, vol.97
-
-
Blundell, J.E.1
Mac Diarmid, J.I.2
-
8
-
-
0030594830
-
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
Caro JF, Kolaczyski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MK, Considine RV. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996; 348: 159-161
-
(1996)
Lancet
, vol.348
, pp. 159-161
-
-
Caro, J.F.1
Kolaczyski, J.W.2
Nyce, M.R.3
Ohannesian, J.P.4
Opentanova, I.5
Goldman, W.H.6
Lynn, R.B.7
Zhang, P.L.8
Sinha, M.K.9
Considine, R.V.10
-
9
-
-
0030928715
-
Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
-
Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997; 138: 4489-4492
-
(1997)
Endocrinology
, vol.138
, pp. 4489-4492
-
-
Cheung, C.C.1
Clifton, D.K.2
Steiner, R.A.3
-
10
-
-
0034905674
-
Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severly obese children
-
Dubern B, Clement K, Pelloux V, Froguel P, Giradet JP, Guy-Grand B, Tounian P. Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severly obese children. J Pediatr 2001; 139: 2004-2009
-
(2001)
J Pediatr
, vol.139
, pp. 2004-2009
-
-
Dubern, B.1
Clement, K.2
Pelloux, V.3
Froguel, P.4
Giradet, J.P.5
Guy-Grand, B.6
Tounian, P.7
-
11
-
-
0343953074
-
Dominant and recessive inheritance of morbid obesity associated with melanocortin4 receptor deficiency
-
Farooqi IS, Yeo GSH, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O'Rahilly S. Dominant and recessive inheritance of morbid obesity associated with melanocortin4 receptor deficiency. J Clin Invest 2000; 106: 271-279
-
(2000)
J Clin Invest
, vol.106
, pp. 271-279
-
-
Farooqi, I.S.1
Yeo, G.S.H.2
Keogh, J.M.3
Aminian, S.4
Jebb, S.A.5
Butler, G.6
Cheetham, T.7
O'Rahilly, S.8
-
12
-
-
0030333003
-
Obesità and physical activity
-
Review
-
Ferro-Luzzi A, Martino L. Obesità and physical activity. Review. Ciba Found Symp 1996; 201: 207-221
-
(1996)
Ciba Found Symp
, vol.201
, pp. 207-221
-
-
Ferro-Luzzi, A.1
Martino, L.2
-
13
-
-
0027227288
-
Molecular cloning expression, and gene localization of a fourth melanocortin receptor
-
Gantz I, Miwa H et al. Molecular cloning expression, and gene localization of a fourth melanocortin receptor. J Biol Chem 1993; 268: 15174-15179
-
(1993)
J Biol Chem
, vol.268
, pp. 15174-15179
-
-
Gantz, I.1
Miwa, H.2
-
14
-
-
12144289073
-
Melanocortin-4 receptor gene variant I103 is negatively associated with obesity
-
Geller F, Reichwald K, Dempfle A, Illig T, Vollmert C, Herpertz S, Siffert W, Platzer M, Hess C, Gudermann T, Biebermann H, Wichmann HE, Schafer H, Hinney A, Hebebrand J. Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet 2004; 74: 572-581
-
(2004)
Am J Hum Genet
, vol.74
, pp. 572-581
-
-
Geller, F.1
Reichwald, K.2
Dempfle, A.3
Illig, T.4
Vollmert, C.5
Herpertz, S.6
Siffert, W.7
Platzer, M.8
Hess, C.9
Gudermann, T.10
Biebermann, H.11
Wichmann, H.E.12
Schafer, H.13
Hinney, A.14
Hebebrand, J.15
-
15
-
-
0033010326
-
Identification and functional analysis of novel human melanocortin-4 receptor variants
-
Gu W, Tu Z et al. Identification and functional analysis of novel human melanocortin-4 receptor variants. Diabetes 1999; 48: 635-639
-
(1999)
Diabetes
, vol.48
, pp. 635-639
-
-
Gu, W.1
Tu, Z.2
-
17
-
-
0012939957
-
Bestimmung von insulinresistenz und insulinsensitivität bei kindern und jugendlichen
-
Heinze E, Horn T, Wabitsch M, Wudy S, Sorgo W, Homoki J. Bestimmung von Insulinresistenz und Insulinsensitivität bei Kindern und Jugendlichen. Monatsschr Kinderheilkd 2002; 150: 1095-1100
-
(2002)
Monatsschr Kinderheilkd
, vol.150
, pp. 1095-1100
-
-
Heinze, E.1
Horn, T.2
Wabitsch, M.3
Wudy, S.4
Sorgo, W.5
Homoki, J.6
-
18
-
-
0041708012
-
Binge eating as a phenotype of melanocortin 4 receptor gene mutations
-
Herpertz S, Siffert W, Hebebrand J. Binge eating as a phenotype of melanocortin 4 receptor gene mutations. N Engl J Med 2003; 349: 606-609
-
(2003)
N Engl J Med
, vol.349
, pp. 606-609
-
-
Herpertz, S.1
Siffert, W.2
Hebebrand, J.3
-
19
-
-
0141564582
-
Melanocortin-4 receptor gene: Case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity
-
Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter AK, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schafer H, Gudermann T, Hebebrand J. Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity. J Clin Endocrinol Metab 2003; 88: 4258-4267
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4258-4267
-
-
Hinney, A.1
Hohmann, S.2
Geller, F.3
Vogel, C.4
Hess, C.5
Wermter, A.K.6
Brokamp, B.7
Goldschmidt, H.8
Siegfried, W.9
Remschmidt, H.10
Schafer, H.11
Gudermann, T.12
Hebebrand, J.13
-
20
-
-
0033343736
-
Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
-
Hinney A, Schmidt A, Notteborn K et al. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. J Clin Endocrinol Metab 1999; 84: 1483-1486
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1483-1486
-
-
Hinney, A.1
Schmidt, A.2
Notteborn, K.3
-
21
-
-
18644363563
-
Melanocortin4 receptor sequence variations are seldom a cause of human obesity: The Swedish obese subjects, the HERITAGE family study, and a Memphis cohort
-
Jacobson P, Ukkola O, Rankinen T, Snyder EE, Leon AS, Rao DC, Skinner JS, Wilmore JH, Lonn L, Cowan Jr GS, Sjostrom L, Bouchard C. Melanocortin4 receptor sequence variations are seldom a cause of human obesity: the Swedish obese subjects, the HERITAGE family study, and a Memphis cohort. J Clin Endocrinol Metab 2002; 87: 4438-4441
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 4438-4441
-
-
Jacobson, P.1
Ukkola, O.2
Rankinen, T.3
Snyder, E.E.4
Leon, A.S.5
Rao, D.C.6
Skinner, J.S.7
Wilmore, J.H.8
Lonn, L.9
Cowan Jr., G.S.10
Sjostrom, L.11
Bouchard, C.12
-
22
-
-
12244281827
-
Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity
-
Larsen LH, Echwald SM, Sorensen TI, Andersen T, Wulff BS, Pedersen O. Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity. J Clin Endocrinol Metab 2005; 90: 219-224
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 219-224
-
-
Larsen, L.H.1
Echwald, S.M.2
Sorensen, T.I.3
Andersen, T.4
Wulff, B.S.5
Pedersen, O.6
-
23
-
-
0037439274
-
Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations
-
Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Perron C, Froguel P, Vaisse C. Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. Hum Mol Genet 2003; 12: 145-153
-
(2003)
Hum Mol Genet
, vol.12
, pp. 145-153
-
-
Lubrano-Berthelier, C.1
Durand, E.2
Dubern, B.3
Shapiro, A.4
Dazin, P.5
Weill, J.6
Perron, C.7
Froguel, P.8
Vaisse, C.9
-
24
-
-
0037066620
-
The role of melanocortins in body weight regulation: Opportiunities for the treatment of obesity
-
MacNeil DJ et al. The role of melanocortins in body weight regulation: opportiunities for the treatment of obesity. Eur J Pharmacol 2002; 440: 141-157
-
(2002)
Eur J Pharmacol
, vol.440
, pp. 141-157
-
-
MacNeil, D.J.1
-
25
-
-
0037350649
-
A novel nonsense mutation in the melanocortin-4 receptor associated with obesity in a Spanish population
-
Marti A, Corbalan MS, Forga L, Martinez JA, Hinney A, Hebebrand J. A novel nonsense mutation in the melanocortin-4 receptor associated with obesity in a Spanish population. Int J Obes Relat Metab Disord 2003; 27: 385-388
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, pp. 385-388
-
-
Marti, A.1
Corbalan, M.S.2
Forga, L.3
Martinez, J.A.4
Hinney, A.5
Hebebrand, J.6
-
26
-
-
0036257961
-
Low frequency of melanocortin-4 receptor (MC4R) mutations in a mediterranean population with early-onset obesity
-
Miraglia Del Giudice E, Cirillo G, Nigro V, Santoro N, D'Urso L, Raimondo P, Cozzolino D, Scafato D, Perrone L. Low frequency of melanocortin-4 receptor (MC4R) mutations in a mediterranean population with early-onset obesity. Int J Obes Relat Metab Disord 2002; 26: 647-651
-
(2002)
Int J Obes Relat Metab Disord
, vol.26
, pp. 647-651
-
-
Miraglia Del Giudice, E.1
Cirillo, G.2
Nigro, V.3
Santoro, N.4
D'Urso, L.5
Raimondo, P.6
Cozzolino, D.7
Scafato, D.8
Perrone, L.9
-
27
-
-
0037927578
-
Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity
-
Nijenhuis WA et al. Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity. J Biol Chem 2003; 278: 22939-22945
-
(2003)
J Biol Chem
, vol.278
, pp. 22939-22945
-
-
Nijenhuis, W.A.1
-
28
-
-
0024547855
-
Genetic and environmental influences on level of habitual physical activity and exercise participation
-
Perusse I, Tremblay A, Leblanc C, Bouchard C. Genetic and environmental influences on level of habitual physical activity and exercise participation. Am J Epidemiol 1989; 129: 1012-1022
-
(1989)
Am J Epidemiol
, vol.129
, pp. 1012-1022
-
-
Perusse, I.1
Tremblay, A.2
Leblanc, C.3
Bouchard, C.4
-
29
-
-
0037469715
-
Bedeutung des melanokortinergen systems für die gewichtsregulation
-
Raab M, Hinney A, Grassl W, Remschmidt H, Hebebrand J. Bedeutung des melanokortinergen Systems für die Gewichtsregulation. Dtsch Med Wochenschr 2003; 128: 447-452
-
(2003)
Dtsch Med Wochenschr
, vol.128
, pp. 447-452
-
-
Raab, M.1
Hinney, A.2
Grassl, W.3
Remschmidt, H.4
Hebebrand, J.5
-
30
-
-
0030481072
-
The loop system beteween neuropeptide Y and leptin in normal and obese rodents
-
Rohner-Jeanrenaud F, Cusin I, Siansbury A, Zakrzewska KE, Jeanrenaud B. The loop system beteween neuropeptide Y and leptin in normal and obese rodents. Horm Metab Res 1996; 28: 642-648
-
(1996)
Horm Metab Res
, vol.28
, pp. 642-648
-
-
Rohner-Jeanrenaud, F.1
Cusin, I.2
Siansbury, A.3
Zakrzewska, K.E.4
Jeanrenaud, B.5
-
31
-
-
0033362016
-
Phenotypes in three pedigrees with autosomal dominant obesity caused by happloinsufficiency mutations in the melanocortin-4 receptor gene
-
Sina M, Hinney A, Ziegler A et al. Phenotypes in three pedigrees with autosomal dominant obesity caused by happloinsufficiency mutations in the melanocortin-4 receptor gene. Am J Hum Genet 1999; 65: 1501-1507
-
(1999)
Am J Hum Genet
, vol.65
, pp. 1501-1507
-
-
Sina, M.1
Hinney, A.2
Ziegler, A.3
-
32
-
-
0034049630
-
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity
-
Stumvoll M et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 2000; 23: 295-301
-
(2000)
Diabetes Care
, vol.23
, pp. 295-301
-
-
Stumvoll, M.1
-
33
-
-
0032754997
-
Two important systems in energy homeostasis: Melanocortins and melanin-concentrating hormone
-
Tritos NA, Maratos-Flier E. Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone. Neuropeptides 1999;33:339-349
-
(1999)
Neuropeptides
, vol.33
, pp. 339-349
-
-
Tritos, N.A.1
Maratos-Flier, E.2
-
34
-
-
0033927916
-
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
-
Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 2000; 106: 253-262
-
(2000)
J Clin Invest
, vol.106
, pp. 253-262
-
-
Vaisse, C.1
Clement, K.2
Durand, E.3
Hercberg, S.4
Guy-Grand, B.5
Froguel, P.6
-
35
-
-
1442327719
-
Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults
-
Valli-Jaakola K, Lipsanen-Nyman M, Oksanen L, Hollenberg AN, Kontula K, Bjorbaek C, Schalin-Jantti C. Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finnish children and adults. J Clin Endocrinol Metab 2004; 89: 940-945
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 940-945
-
-
Valli-Jaakola, K.1
Lipsanen-Nyman, M.2
Oksanen, L.3
Hollenberg, A.N.4
Kontula, K.5
Bjorbaek, C.6
Schalin-Jantti, C.7
-
36
-
-
17944364621
-
Adipositas im kindes- und jugendalter. Basis-informationen und leitlinien für diagnostik, therapie und prävention
-
Wabitsch M, Kunze D. Adipositas im Kindes- und Jugendalter. Basis-informationen und Leitlinien für Diagnostik, Therapie und Prävention. Monatsschr Kinderheilkd 2001; 149: 805-806
-
(2001)
Monatsschr Kinderheilkd
, vol.149
, pp. 805-806
-
-
Wabitsch, M.1
Kunze, D.2
-
37
-
-
0036645562
-
Cardiovascular health in childhood: A Statement for health professionals from the Committee on atherosclerosis, hypertension and obesity in the young (AHOY)
-
Williams CL, Hayman LL et al. Cardiovascular health in childhood: A Statement for health professionals from the Committee on atherosclerosis, hypertension and obesity in the young (AHOY). Circulation 2002; 106: 143-160
-
(2002)
Circulation
, vol.106
, pp. 143-160
-
-
Williams, C.L.1
Hayman, L.L.2
-
38
-
-
0037341511
-
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms
-
Yeo GS, Lank EJ, Farooqi IS, Keogh J, Challis BG, O'Rahilly S. Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms. Hum Mol Genet 2003; 12: 561-574
-
(2003)
Hum Mol Genet
, vol.12
, pp. 561-574
-
-
Yeo, G.S.1
Lank, E.J.2
Farooqi, I.S.3
Keogh, J.4
Challis, B.G.5
O'Rahilly, S.6
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