P38 MAPK activation by TGF-β1 increases MLC phosphorylation and endothelial monolayer permeability

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 282, Issue 1 26-1, 2002, Pages

  Goldberg, Peter L ^a   Macnaughton, Darren E ^a   Clements, Richard T ^a   Minnear, Fred L ^a   Vincent, Peter A ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Cycloheximide; Endothelial cells; Mitogen activated protein kinase; Myosin light chain phosphorylation; Transforming growth factor 1

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOHEXIMIDE; HEAT SHOCK PROTEIN 70; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MYOSIN LIGHT CHAIN; RAS PROTEIN; RHO FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CELL LYSATE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DEPHOSPHORYLATION; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

EID: 0036086629     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2002.282.1.l146     Document Type: Article

References (35)

1. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells
2. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
3. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
4. Inhibition of serine-threonine protein phosphatases decreases barrier function of rat pulmonary microvascular endothelial cells
5. Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells
6. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
7. Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor
8. Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation
9. Regulation of endothelial cell gap formation and paracellular permeability
10. Monitoring fibroblast behavior in tissue culture with an applied electric field
11. Myosin light chain kinase-regulated endothelial cell contraction: The relationship between isometric tension, actin polymerization, and myosin phosphorylation
12. Thrombospondin-1 induces tyrosine phosphorylation of adherens junction proteins and regulates an endothelial paracellular pathway
13. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
14. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells
15. Rearrangement of adherens junction by transforming growth factor-β: Role of contraction
16. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
17. Regulation of cell motility by mitogenactivated protein kinase
18. Regulation of vascular endothelial barrier function
19. Activators and effectors of ras p21 proteins
20. Culture of rat and pig aortic endothelial cells: Differences in their isolation, growth rate and glycosaminoglyean synthesis
21. Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta 1 on gene expression
22. Differential effect of MLC kinase in TNF-α-induced endothelial cell apoptosis and barrier dysfunction
23. TGF-beta is a critical mediator of acute lung injury
24. p 38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
25. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
26. The activity of guanine exchange factor net1 is essential for transforming growth factor-beta-mediated stress fiber formation
27. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase
28. Adenovector-mediated gene transfer of active transforming growth factor-beta 1 induces prolonged severe fibrosis in rat lung
29. Electrical method for detection of endothelial cell shape change in real time: Assessment of endothelial barrier function
30. Extracellular matrix production regulation by TGF-beta in corneal endothelial cells
31. Rho GTPases and signaling networks
32. Regulation of endothelial cell gap formation and barrier function by myosin-associated phosphatase activities
33. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
34. Keratinocyte growth factor decreases pulmonary edema, transforming growth factor-beta and platelet-derived growth factor-BB expression, and alveolar type II cell loss in bleomycin-induced lung injury
35. Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells