Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways

Food and Chemical Toxicology

Volumn 43, Issue 10, 2005, Pages 1483-1495

  Ho, Yuan Soon ^a   Wu, Chih Hsiung ^b   Chou, Hsiao Min ^a   Wang, Ying Jan ^c   Tseng, How ^a   Chen, Chien Ho ^a   Chen, Li Ching ^d   Lee, Chia Hwa ^a   Lin, Shyr Yi ^b,e  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d TZU CHI UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Cell cycle; Colon cancer; Cytotoxicity; Econazle

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; ECONAZOLE; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL LINE; COLON CANCER; CYTOMETRY; CYTOTOXICITY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUDE MOUSE; PROTEIN BLOOD LEVEL; TUMOR XENOGRAFT; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 8; CASPASES; CDC2-CDC28 KINASES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; DNA FRAGMENTATION; ECONAZOLE; FLOW CYTOMETRY; G0 PHASE; G1 PHASE; HUMANS; IMMUNOPRECIPITATION; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROLOGOUS;

MUS MUSCULUS;

EID: 21844434671     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.04.002     Document Type: Article

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