MTPA (Mosher) amides of cyclic secondary amines: Conformational aspects and a useful method for assignment of amine configuration

Journal of Organic Chemistry

Volumn 61, Issue 6, 1996, Pages 2056-2064

  Hoye, Thomas R ^a   Renner, Matthew K ^a  

^a University of Minnesota   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE CONFIGURATION; AMIDE BOND; CHIRAL ALCOHOLS; CONFORMATIONAL ASPECTS; COUPLING CONSTANTS; CYCLIC AMINES; METHOXY; NMR CHEMICAL SHIFTS; PRIMARY AMINES; PYRROLIDINES; ROTAMERS; SECONDARY AMINES; TRIFLUOROMETHYL;

AMIDES; CONFORMATIONS;

AMINES;

EID: 0001692739     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo952043h     Document Type: Article

References (25)

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18. Compound numbers incorporating a slash (a/c or b/d) represent a rapidly equilibrating pair of chair conformations that gives rise to a single, time-averaged set of chemical shifts and coupling constants.
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23. Selected protons have been removed for clarity in this and all subsequent figures.
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25. The CAS name for this compound is [R-(R*,R*)]-2- methyl-1-3,3,3-trifluoro-2-methoxy-1-oxo-2-phenylpropyl)piperidine.