Chemoenzymatic approach to enantiopure streptogramin B variants: Characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis

Journal of the American Chemical Society

Volumn 127, Issue 26, 2005, Pages 9571-9580

  Mahlert, Christoph ^a   Sieber, Stephan A ^a,b   Grünewald, Jan ^a   Marahiel, Mohamed A ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIODIVERSITY; BIOSYNTHESIS; ECOLOGY; ENZYME KINETICS; MICROBIOLOGY; YEAST;

ANTIMICROBIAL AGENTS; CHEMOENZYMATIC APPROACH; MULTIRESISTANT COCCI; STREPTOGRAMIN B VARIANTS;

ENZYMES;

BACTERIAL ENZYME; CYCLOPEPTIDE; ESTER; LACTONE; MIKAMYCIN B; PEPTIDE DERIVATIVE; PEPTIDE SYNTHASE; PHENYLGLYCINE; POLYPEPTIDE ANTIBIOTIC AGENT; PRISTINAMYCIN I CYCLASE; RECOMBINANT ENZYME; RECOMBINANT SNBDE THIOL ESTER HYDROLASE; STREPTOGRAMIN DERIVATIVE; THIOESTER; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CHEMICAL REACTION; CLONING; COVALENT BOND; CYCLIZATION; DYNAMIC KINETIC RESOLUTION ASSAY; ENZYME ANALYSIS; ENZYME SPECIFICITY; MACROLACTAMIZATION; PEPTIDE BOND; PROTEIN DOMAIN; PROTEIN VARIANT; RACEMIZATION; RING CLOSING METATHESIS; STEREOCHEMISTRY; STREPTOMYCES; STREPTOMYCES PRISTINAESPIRALIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CYCLIZATION; KINETICS; PEPTIDE SYNTHASES; STEREOISOMERISM; STREPTOGRAMIN B; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIOLESTER HYDROLASES;

EID: 21644433696     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja051254t     Document Type: Article

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