Identification, design, synthesis, and pharmacological activity of (4-ethyl-piperazin-1-yl)-phenylmethanone derivatives with neuroprotective properties against β-amyloid-induced toxicity

Neuropharmacology

Volumn 49, Issue 1, 2005, Pages 86-96

  Lecanu, Laurent ^a   Yao, Wenguo ^a   Piechot, Alexander ^c   Greeson, Janet ^b   Tzalis, Dimitrios ^c   Papadopoulos, Vassilios ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b Samaritan Pharmaceuticals   (United States)

^c Taros Custom Chemicals   (Germany)

Author keywords

Alzheimer's disease; Amyloid; ATP; Glutamate; Piperazinyl

Indexed keywords

3 (4 BENZOYLPIPERAZIN 1 YLMETHYL) 6,6A EPOXY 6,9 DIMETHYL 3A,4,5,6,6A,7,9A,9B OCTAHYDRO 3H AZULENO[4,5 B]FURAN 2 ONE; ACETIC ACID 5 ACETOXY 3 (4 BENZOYLPIPERAZIN 1 YLMETHYL) 4 HYDROXY 4A,8 DIMETHYL 2 OXODODECAHYDROAZULENO[6,5 B]FURAN 7 YL ESTER; ACETIC ACID 7 ACETOXY 3 (4 BENZOYLPIPERAZIN 1 YLMETHYL) 5 HYDROXY 4A,8 DIMETHYL 2 OXODODECAHYDROAZULENO[6,5 B]FURAN 4 YL ESTER; AMYLOID BETA PROTEIN[1-42]; AZULENE DERIVATIVE; NEUROPROTECTIVE AGENT; SP 008; SP 015; SP 016; SP 017; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTEMISIA; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SYNTHESIS; INULA; MENTAL FUNCTION; MITOCHONDRION; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; CELL SURVIVAL; CHROMATOGRAPHY, THIN LAYER; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FREE RADICALS; NEUROPROTECTIVE AGENTS; PC12 CELLS; PEPTIDE FRAGMENTS; PHYTOESTROGENS; PIPERAZINES; PLANT PREPARATIONS; RATS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 21344448607     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.01.028     Document Type: Article

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