Inhibition of Adrenal Cortical Steroid Formation by Procaine Is Mediated by Reduction of the cAMP-Induced 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Messenger Ribonucleic Acid Levels

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 3, 2003, Pages 1148-1157

  Xu, Jing ^a   Lecanu, Laurent ^a   Han, Zeqiu ^a   Yao, Zhixing ^a   Greeson, Janet ^b   Papadopoulos, Vassilios ^a,c  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Samaritan Pharmaceuticals   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUCLADESINE; CORTICOSTEROID; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME P450; GLUCOCORTICOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; PROCAINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADRENAL CORTEX; ADRENAL CORTEX CELL; ANIMAL CELL; ARTICLE; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; DRUG EFFECT; ENZYME ACTIVITY; ENZYME REGULATION; HORMONAL REGULATION; HYPERCORTISOLISM; MESSENGER RNA SYNTHESIS; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RNA STABILITY; STEROIDOGENESIS;

ADRENAL CORTEX; ADRENAL GLAND NEOPLASMS; ANESTHETICS, LOCAL; ANIMALS; BUCLADESINE; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; IMMUNOBLOTTING; LEYDIG CELLS; LIVER; LUCIFERASES; MALE; MICE; MITOCHONDRIA; PROCAINE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROIDS; TRANSFECTION;

EID: 0344304771     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.055178     Document Type: Article

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