Pre-ischaemic administration of procaine suppresses ischaemic glutamate release and reduces neuronal damage in the gerbil hippocampus

British Journal of Anaesthesia

Volumn 83, Issue 3, 1999, Pages 472-474

  Adachi, N ^a   Chen, J ^a   Nakanishi, K ^a   Arai, T ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Anaesthetics local, procaine; Brain, ischaemia; Gerbil; Nerve, neurotransmitters; Protein, amino acids

Indexed keywords

AMINO ACID; ASPARTIC ACID; GLUTAMIC ACID; GLYCINE; LOCAL ANESTHETIC AGENT; NEUROTRANSMITTER; PROCAINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DIALYSATE; GERBIL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MICRODIALYSIS; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL;

EID: 0032884215     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/83.3.472     Document Type: Article

References (4)

1. Benveniste H, Drejer J, Schousboe A, Diemer NH. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 1984; 43: 1369-74
2. 2+ and energy levels during in vitro ischemia in the gerbil hippocampal slice. J Neurochem 1994; 62: 626-34
3. Chen J, Adachi N, Liu K, Nagaro T, Aral T. Improvement of ischemic damage in gerbil hippocampal neurons by procaine. Brain Res 1998; 792: 16-23
4. Chen J, Adachi N, Tsubota S, Nagaro T, Arai T. Dexamethasone augments ischemia-induced extracellular accumulation of glutamate in gerbil hippocampus. Eur J Pharmacol 1998; 347: 67-70