Chronic corticosterone administration dose-dependently modulates Aβ((1-42))- and NMDA-induced neurodegeneration in rat magnocellular nucleus basalis

Journal of Neuroendocrinology

Volumn 12, Issue 6, 2000, Pages 486-494

  Abraham I ^d   Harkany, T ^a   Horvath, K M ^d   Veenema, A H ^d   Penke, B ^b   Nyakas, C ^a   Luiten, P G M ^c  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d NONE

Author keywords

amyloid; Corticosterone; Excitotoxicity; Neurodegeneration; Neuroprotection

Indexed keywords

11BETA,17BETA DIHYDROXY 6 METHYL 17ALPHA (1 PROPYNYL)ANDROSTA 1,4,6 TRIEN 3 ONE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CORTICOSTERONE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CHOLINERGIC NERVE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DOSE RESPONSE; HISTOCHEMISTRY; MAGNOCELLULAR NUCLEUS; MALE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OLIVARY NUCLEUS; PRIORITY JOURNAL; RAT;

AMYLOID BETA-PROTEIN; ANIMALS; BASAL NUCLEUS OF MEYNERT; CORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; MALE; N-METHYLASPARTATE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; TIME FACTORS;

EID: 0342369460     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2000.00475.x     Document Type: Article

References (58)

1. Fuxe K, Wikström A, Okret S, Agnati FL, Härfstrand A, Yu Z, Granholm L, Zoli M, Vale W, Gustafsson J. Mapping of glucocorticoid receptor immunoreactive neurones in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor. Endocrinology 1985; 117: 1083-1812.
2. McEwen BS, de Kloet ER, Rostene W. Adrenal steroid receptors and action in the nervous system. Physiol Rev 1986; 66: 1121-1188.
3. Reul JMHM, de Kloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 1985; 117: 2505-2511.
4. Behl C, Lezoualc'h F, Trapp T, Widmann M, Skutella T, Holsboer F. Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurones in vitro. Endocrinology 1997; 138: 101-106.
5. Krugers HJ, Kemper RH, Korf J, Ter Horst GJ, Knollema S. Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels? J Cereb Blood Flow Metab 1998; 18: 386-390.
6. Landfield PW. The role of glucocorticoids in brain ageing and Alzheimer's disease: an integrative physiological hypothesis. Exp Gerontol 1994; 29: 311.
7. Sapolsky RM, Pulsinelli WA. Glucocorticoids potentiate ischemic injury to neurones: therapeutic implications. Science 1985; 229: 1397-1399.
8. Tuor UI. Glucocorticoids and the prevention of hypoxic-ischemic brain damage. Neurosci Biobehav Rev 1997; 21: 175-179.
9. Jaarsma D, Postema F, Korf J. Time course and distribution of neuroneal degeneration in the dentate gyrus of rat after adrenalectomy: a silver impregnation study. Hippocampus 1992; 2: 143-150.
10. MacLennan KM, Smith PF, Darlington CL. Adrenalectomy-induced neuronal degeneration. Progr Neurobiol 1998; 54: 481-498.
11. Lowy MT, Wittenberg L, Novotny S. Adrenalectomy attenuates kainic-acid spectrin proteolysis and heat-shock protein 70 induction in hippocampus and cortex. J Neurochem 1994; 63: 886-894.
12. Sapolsky RM. A mechanism for glucocorticoid toxicity in the hippocampus: increased neuroneal vulnerability to metabolic insults. J Neurosci 1985; 5: 1227-1231.
13. Hortnagl H, Berger ML, Havelec L, Hornykiewicz O. Role of glucocorticoids in the cholinergic degeneration in rat hippocampus induced by ethylcholine aziridium (AF64A). J Neurosci 1993; 13: 2939-2945.
14. Watanabe Y, Gould E, McEwen BS. Stress induces atrophy of apical dendrites of hippocampal pyramidal neurones. Brain Res 1992; 588: 341-345.
15. Sapolsky RM, Uno H, Rebert CS, Finch CE. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J Neurosci 1990; 10: 2897-2902.
16. Johansson A, Olsson T, Carlberg B, Karlsson K, Fagerlund M. Hypercortisolism after stroke: partly cytokine-mediated? J Neurol Sci 1997; 20: 43-47.
17. Weiner MF, Vobach S, Olsson K, Svetlik D, Risser RC. Cortisol secretion and Alzheimer's disease. Biol Psychiatry 1997; 42: 1030-1038.
18. Kerr DS, Campbell LW, Hao S-Y, Landfield PW. Corticosteroid modulation of hippocampal potentials: increased effect with ageing. Science 1989; 245: 1505-1509.
19. Gaykema RPA, Nyakas C, Horvath E, Hersh LB, Majtenyi C, Luiten PGM. Cholinergic fibre aberrations in nucleus basalis lesioned rat and Alzheimer's disease. Neurobiol Aging 1992; 13: 441-448.
20. Geula C, Mesulam MM. Systematic regional variations in the loss of cortical cholinergic fibres in Alzheimer's disease. Cereb Cortex 1996; 6: 165-177.
21. Giovannelli L, Casamenti F, Scali C, Bartolini L, Pepeu G. Differential effects of amyloid peptides β-(1-40) and β-(25 35) injections into the rat nucleus basalis. Neuroscience 1995; 66: 781-792.
22. 2425 35 in rat nucleus basalis induces behavioral dysfunctions impairs learning and memory and disrupts cortical cholinergic innervation. Behav Brain Res 1998; 90: 133-145.
23. Harkany T, Abraham I, Laskay G, Timmerman W, Jost K, Zarandi M, Penke B, Nyakas C, Luiten PGM. Proprionyl-IIGL tetrapeptide antagonizes β-amyloid excitotoxicity in rat nucleus basalis. Neuroreport 1999; 10: 1693-1698.
24. Harkany T, Mulder J, Sasvari M, Abraham I, Konya C, Zarandi M, Penke B, Luiten PGM, Nyakas C. N-methyl-D-aspartate receptor antagonist MK-801 and radical scavengers protect cholinergic nucleus basalis neurones against β-amyloid neurotoxicity. Neurobiol Dis 1999; 6: 109-121.
25. Luiten PGM, Harkany T, Farkas E, Abraham I, de Jong GI, Penke B, Nyakas C. Neuronal and cerebrovascular degeneration in ageing and dementia. The role of calcium homeostasis. Clin Neurosci 1998; 51: 9-10.
26. Mattson MP. Secreted forms of β-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurones. J Neurobiol 1994; 25: 439-450.
27. 2+ antagonist nimodipine, influence of ageing and developmental drug treatment, Neurodegeneration 1995; 4: 1-7.
28. (1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis. Brain Res 1995; 95: 71-75.
29. Ábrahám I, Juhász G, Kékesi AK, Kovács KJ. Effect of intrahippocampal dexamethasone on extracellular level of amino acid transmitters and neuroneal excitability. Brain Res 1996; 733: 56-63.
30. Kovács KJ, Makara GB. Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion. Brain Res 1988; 474: 205-210.
31. Hedreen JC, Bacon SJ, Price DL. A modified histochemical technique to visualize acetylcholinesterase containing axons. J Histochem Cytochem 1985; 33: 134-140.
32. Paxinos G, Watson C. The Rat Brain in Stereotoxic Coordinates, 2nd edn. Sydney: Academic Press, 1986.
33. Cintra A, Zoli M, Rosén L, Agnati LF, Okret S, Wikstrom AC, Gustafsson JA, Fuxe K. Mapping and computer assisted morphometry and microdensitometry of glucocorticoid receptor immunoreactive neurones and glial cells in the rat central nervous system. Neuroscience 1994; 62: 843-897.
34. de Kloet ER, Joëls M. Corticosteroid hormones in neuroprotection and brain damage. Curr Op Endocrinol Diabetes 1996; 3: 184-192.
35. de Kloet ER, Vreugdenhil E, Oitzl MS, Joëls M. Brain corticosteroid receptor balance in health and disease. Endoc Rev 1998; 19: 269-301.
36. Joëls M, de Kloet ER. Mineralocorticoid and glucocorticoid receptors in the brain: implication for ion permeability and transmitter system. Progr Neurobiol 1994; 43: 1-36.
37. Horner H, Packan D, Sapolsky R. Glucocorticoids inhibit glucose transport in cultured hippocampal neurones and glia. Neuroendocrinology 1990; 52: 57-63.
38. Sapolsky RM. Stress, glucocorticoids, and damage to the nervous system: the current state of confusion. Stress 1996; 1: 1-19.
39. Karst H, de Kloet ER. Joëls M. Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long term changes in hippocampal CA1 cells, in the fully kindled state. Eur J Neurosci 1999; 11: 889-898.
40. Karst H, Wadman WJ, Joëls M. Corticosteroid receptor modulation of calcium currents in rat hippocampal CA1 neurones. Brain Res 1994; 649: 234-242.
41. 2+ conductances: relevance to brain ageing. Proc Natl Acad Sci USA 1992; 89: 8527-8531.
42. Sloviter RS, Sollas AL, Dean E, Neubort S. Adrenalectomy-induced granule cell degeneration in the rat hippocampal dentate gyrus: characterization of an in vivo model of controlled neuroneal death. J Comp Neurol 1993; 330: 324-336.
43. Nair SM, Werkman TR, Craig J, Finnel R, Joels M, Eberwine JH. Corticosteroid regulation of ion channel conductances and mRNA levels in individual hippocampal CA1 neurones. J Neurosci 1998; 18: 2685-2696.
44. 2+ channel activity in area CA1 of hippocampus. Proc Natl Acad Sci USA 1991; 88: 6467-6471.
45. Lobner D, Lipton P. Intracellular calcium levels and calcium fluxes in the CAl region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage. J Neurosci 1993; 13: 4861-4871.
46. Koh J, Yang LL, Cotman CW. β-Amyloid protein increases the vulnerability of cultured cortical neurones to excitotoxic damage. Brain Res 1990; 533: 315-320.
47. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurones vulnerable to excitotoxicity. J Neurosci 1992; 12: 376-389.
48. Maurice T, Lockhart BP, Su TP, Privat A. Reversion of β25-35-amyloid peptide-induced amnesia by NMDA receptor-associated glycine site agonists. Brain Res 1996; 731: 249-253.
49. O'Mahony S, Harkany T, Rensink AAM, Abraham I, De Jong GI, Varga JL, Zarándi M, Penke B, Nyakas C, Luiten PGM, Leonard BE. β-Amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: Reversal by NMDA receptor blockade. Brain Res Bull 1998; 45: 405-411.
50. Parpura-Gill A, Beitz Uemura E. The inhibitory effects of β-amyloid on glutamate and glucose uptakes by cultured astrocytes. Brain Res 1997; 754: 65-71.
51. Margarinos AM, McEwen BS, Flugge G, Fuchs E. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurones in subordinate tree shrews. J Neurosci 1996; 16: 3534-3540.
52. Sousa N, Paula-Barbosa MM, Almeida OFX. Ligand and subfield specificity of corticoid-induced neuroneal loss in the rat hippocampal formation. Neuroscience 1999; 89: 1079-1087.
53. Kadakaro M, Ito M, Gross PM. Local cerebral glucose utilization is increased in acutely adrenalectomized rats. Neuroendocrinology 1988; 47: 329-334.
54. Stein-Behrens B, Mattson MP, Chang L, Yeh M, Sapolsky R. Stress exacerbates neurone loss and cytoskeletal pathology in hippocampus. J Neurosci 1994; 14: 5373-5380.
55. McIntosh LJ, Hong KE, Sapolsky RM. Glucocorticoids may alter antioxidant enzyme capacity in the brain: baseline studies. Brain Res 1998; 791: 209-214.
56. Ábráham I, Juhász G, Kékesi AK, Kovács KJ. Corticosterone peak is responsible for stress-induced elevation of glutamate in the hippocampus. Stress 1998; 2: 171-181.
57. Stein-Behrens B, Lin WJ, Sapolsky RM. Physiological elevations of glucocorticoids potentiate glutamate accumulation in the hippocampus. J Neurochem 1994; 63: 596-602.
58. Olney JW, Wozniak DF, Farber NB. Excitotoxic neurodegeneration in Alzheimer's disease. Arch Neurol 1997; 54: 1234-1240.