Relation of the [3H]γ-hydroxybutyric acid (GHB) binding site to the γ-aminobutyric acid(B) (GABA(B)) receptor in rat brain

Biochemical Pharmacology

Volumn 52, Issue 8, 1996, Pages 1235-1243

  Snead III, O Carter ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

absence seizures; binding; epilepsy; G protein; GABA(B) receptor; pertussis toxin; presynaptic; hydroxybutyrate

Indexed keywords

2 HYDROXYSACLOFEN; 3 AMINOPROPANEPHOSPHINIC ACID; 3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 4 HYDROXYBUTYRIC ACID; 4 HYDROXYBUTYRIC ACID ANTAGONIST; 5,5 DIMETHYL 2 MORPHOLINEACETIC ACID; ARECAIDINE; BACLOFEN; GABAERGIC RECEPTOR AFFECTING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; GUANYLYLIMIDODIPHOSPHATE; NCS 382; PERTUSSIS TOXIN; PHACLOFEN; POSTSYNAPTIC RECEPTOR; PRESYNAPTIC RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG; 3-AMINOPROPYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; FUSED ALICYCLIC AROMATIC COMPOUND; ORGANOPHOSPHORUS COMPOUND; OXYBATE SODIUM;

ABSENCE; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; BRAIN REGION; CONTROLLED STUDY; FRONTAL CORTEX; GRAND MAL SEIZURE; HIPPOCAMPUS; MALE; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; THALAMUS; TISSUE DISTRIBUTION; ANIMAL; BRAIN; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; METABOLISM; SEIZURE; SPRAGUE DAWLEY RAT; STEREOISOMERISM;

ANIMALS; AUTORADIOGRAPHY; BACLOFEN; BENZOCYCLOHEPTENES; BINDING SITES; BRAIN; GABA AGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GUANOSINE TRIPHOSPHATE; MALE; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; SEIZURES; SODIUM OXYBATE; STEREOISOMERISM;

EID: 0030601495     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00477-7     Document Type: Article

References (52)

1. 1. Snead OC III, Furner R and Liu CC, In vivo conversion of γ-aminobutyric acid and 1,4-butanediol to γ-hydroxybutyric acid in rat brain: Studies using stable isotopes. Biochem Pharmacol 38: 4375-4380, 1989.
2. 2. Cash CD, Gamma-hydroxybutyrate: An overview of the pros and cons for it being a neurotransmitter and/or a useful therapeutic agent. Neurosci Biobehav Rev 18: 291-304, 1994.
3. 3. Snead OC III, γ-Hydroxybutyric acid in subcellular fractions of rat brain. J Neurochem 48: 196-201, 1987.
4. 4. Cash CD, Maitre M and Mandel P, Purification from human brain and some properties of two NADPH-linked aldehyde reductases which reduce succinic semialdehyde to 4-hydroxybutyric acid. J Neurochem 33: 1169-1175, 1979.
5. 5. Weissman-Nanopoulos D, Rumigny JF, Mandel P, Vincendon G and Maitre M, Immunocytochemical localization in rat brain of the enzyme that synthesizes γ-hydroxybutyric acid. Neurochem Int 4: 5223-5229, 1982.
6. 6. Rumigny JF, Maitre M, Cash CD and Mandel P, Regional and subcellular localization in rat brain of the enzymes that can synthesize γ-hydroxybutyric acid. J Neurochem 36: 1433-1438, 1981.
7. 7. Vayer P, Ehrhardt J-D, Gobaille S, Mandel P and Maitre M, Gamma hydroxybutyrate distribution and turnover rates in discrete brain regions of the rat. Neurochem Int 12: 53-59, 1988.
8. 8. Benavides J, Rumigny JF, Bourguignon JJ, Wermuth CG, Mandel P and Maitre M, High affinity binding sites for γ-hydroxybutyric acid in rat brain. Life Sci 30: 953-961, 1982.
9. 3H]hydroxybutyrate binding sites as determined by quantitative autoradiography. J Neurochem 49: 1025-1032, 1987.
10. 10. Maitre M, Cash CD, Weissman-Nanopouios D and Mandel P, Depolarization-evoked release of γ-hydroxybutyrate from rat brain slices. J Neurochem 41: 287-290, 1983.
11. 11. Hechler V, Bourguignon JJ, Wermuth CG, Mandel P and Maitre M, γ-Hydroxybutyrate uptake by rat brain striatal slices. Neurochem Res 10: 387-396, 1985.
12. B binding sites: Relation to the development of experimental absence seizures. Brain Res 659: 147-156, 1994.
13. 13. Snead OC III, Gamma hydroxybutyrate in monkey. I. Electroencephalographic, behavioral, and pharmacokinetic studies. Neurology 28: 636-642, 1978.
14. 14. Snead OC III, γ-Hydroxybutyrate model of generalized absence seizures: Further characterization and comparison with other absence models. Epilepsia 29: 361-368, 1988.
15. B receptors. J Neurol Transm 35(Suppl): 155-177, 1992.
16. 16. Snead OC III, Hechler V, Vergnes M, Marescaux C and Maitre M, Increased γ-hydroxybutyric acid receptors in thalamus of a genetic animal model of petit mal epilepsy. Epilepsy Res 7: 121-128, 1990.
17. B receptor site distribution in the rat central nervous system. Neuroscience 20: 365-383, 1987.
18. B receptor-mediated hyperpolarization. Neuroscience 66: 133-141, 1995.
19. B receptors. Eur J Pharmacol 212: 291-294, 1992.
20. B receptors. Trends Pharmacol Sci 14: 259-261, 1993.
21. B receptor subtypes in the rat cerebral cortex. J Pharmacol Exp Ther 262: 114-118, 1992.
22. B receptors. Int Rev Neurobiol 36: 97-223, 1994.
23. 23. Maitre M, Hechler V, Vayer P, Gobaille S, Cash CD, Schmidtt M and Bourguignon JJ, A specific γ-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties. J Pharmacol Exp Ther 255: 657-663, 663, 1990.
24. B receptor binding by guanyl nucleotides. J Neurochem 42: 652-657, 1984.
25. B receptors to the same channels in hippocampus. Science 234: 1261-1265, 1986.
26. 3H]γ-hydroxybutyric acid binding sites in the thalamus and cortex. Neuroscience 56: 11-21, 1993.
27. 27. Banerjee PK and Snead OC III, Thalamic mediodorsal and intralaminar nuclear lesions disrupt the generation of experimentally induced generalized absence-like seizures in rats. Epilepsy Res 17: 193-205, 1994.
28. 28. Snead OC III and Nichols AC, γ-Hydroxybutyric acid binding sites: Evidence for coupling to a chloride anion channel. Neuropharmacology 26: 1519-1523, 1987.
29. 29. Paxinos G and Watson C, The Rat Brain in Stereotaxic Coordinates. Academic Press, New York, 1986.
30. B receptors in rat hippocampus. Eur J Pharmacol 211: 337-341, 1992.
31. B receptor antagonists; From synthesis to therapeutic applications. Trends Pharmacol Sci 14: 391-394, 1993.
32. 32. Bolser DC, Blythin DJ, Chapman RW, Egan RW, Hey JA, Rizzo C, Kuo S-C and Kreutner W, The pharmacology of SCH 50911: A novel, orally-active GABA-B receptor antagonist. J Pharmacol Exp Ther 274: 1393-1398, 1995.
33. B receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J Pharmacol Exp Ther 274: 1399-1403, 1995.
34. 34. Snead OC III, The γ-hydroxybutyrate model of absence seizures: Correlation of regional brain levels of γ-hydroxybutyric acid and γ-butyrolactone with spike wave discharges. Neuropharmacology 30: 163-167, 1991.
35. B binding sites in rat central nervous system: A quantitative autoradiographic study. Neuroscience 34: 341-357, 1990.
36. 36. Munson PJ, LIGAND: A computerized analysis of ligand binding data. Methods Enzymol 92: 543-576, 1983.
37. 37. McPherson GA, A practical computer based approach to the analysis of radioligand binding experiments. Comput Programs Biomed 17: 107-114, 1983.
38. 38. Winer BJ, Statistical Principles in Experimental Design. McGraw Hill, New York, 1971.
39. B-mediated mechanisms in experimental generalized absence seizures. Eur J Pharmacol 213: 343-349, 1992.
40. B neurotransmission in the control of absence seizures in the rat. Neuroscience 48: 87-93, 1992.
41. B receptor activation in absence seizures of lethargic (lh/lh) mice. Science 257: 398-401, 1992.
42. 42. Liu Z, Snead OC III, Vergnes M, Depaulis A and Marescaux C, Intrathalamic injections of γ-hydroxybutyric acid increase genetic absence seizures in rats. Neurosci Lett 125: 19-21, 1991.
43. B and γ-hydroxybutyric acid receptor antagonists. Pharmacol Biochem Behav 53: 73-79, 1996.
44. 44. Enna SJ and Maggi A, Biochemical pharmacology of GABAergic agonists. Life Sci 34: 1727-1736, 1979.
45. A receptor function in the γ-hydroxybutyrate model of generalized absence seizures. Neuropharmacology 32: 401-409, 1993.
46. B) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): A possible mechanism for the generation of absence-like seizures induced by GHB. J Pharmacol Exp Ther 273: 1534-1543, 1995.
47. 47. Calabresi P, Mercuri NB, De Murtas M and Bernardi G, Involvement of GABA systems in feedback regulation of glutamate- and GABA-mediated synaptic potentials in rat neostriatum. J Physiol (Lond) 440: 581-599, 1991.
48. i2. FEBS Lett 271: 231-235, 1990.
49. o: Antisense oligonucleotide studies. J Physiol (Lond) 470: 1-11, 1993.
50. 50. Schutz W and Freissmuth M, Reverse intrinsic activity of antagonists on G protein-coupled receptors. Trends Pharmacol Sci 13: 376-385, 1992.
51. 51. Reisine T, Pertussis toxin in the analysis of receptor mechanisms. Biochem Pharmacol 39: 1499-1504, 1990.
52. 52. Potier B and Dutar P, Presynaptic inhibitory effect of baclofen on hipocampal synaptic transmission involves a pertussis toxin-sensitive G protein. Eur J Pharmacol 231: 427-433, 1993.