Hypermethylation of tumor suppressor genes (p16INK4A, p14 ARF and APC) in adenocarcinomas of the upper gastrointestinal tract

International Journal of Cancer

Volumn 111, Issue 2, 2004, Pages 224-228

  Sarbia, Mario ^a   Geddert, Helene ^b   Klump, Bodo ^c   Kiel, Sybille ^b   Iskender, Erol ^b   Gabbert, Helmut Erich ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Barrett's esophagus; Cardiac cancer; Gastric cancer

Indexed keywords

APC PROTEIN; PROTEIN P14; PROTEIN P16;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; BARRETT ESOPHAGUS; CONTROLLED STUDY; DNA METHYLATION; ESOPHAGUS CARCINOMA; FEMALE; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BARRETT ESOPHAGUS; CARDIA; DNA METHYLATION; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GENES, APC; GENES, P16; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 3142663169     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20212     Document Type: Article

References (29)

1. Devesa SS, Blot, WJ, Fraumeni, JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998;83:2049-53.
2. Falk GW. Barrett's esophagus. Gastroenterology 2002;122:1569-91.
3. Hamilton SR, LA Aaltonen, eds. World Health Organization classification of tumours, pathology and genetics of tumours of the digestive system. Lyon: IARC Press, 2000.
4. Tajima Y, Nakanishi Y, Yoshino T, Kokawa A, Kusano M, Shimoda T. Clinicopathological study of early adenocarcinoma of the gastric cardia: comparison with early adenocarcinoma of the distal stomach and esophagus. Oncology 2001;61:1-9.
5. Wijnhoven BPL, Siersema PD, Hop WCJ, van Dekken H, Tilanus HW. Adenocarcinoma of the distal oesophagus and gastric cardia are one clinical entity. Br J Surg 1998;86:529-35.
6. El-Rifai W, Frierson HF, Moskaluk CA, Harper JC, Petroni GR, Bissonette EA, Jones DR, Knuutila S, Powell SM. Genetic differences between adenocarcinomas arising in Barrett's esophagus and gastric mucosa. Gastroenterology 2001;121:592-8.
7. Craig Stocks S, Pratt N, Sales M, Johnston DA, Thompson AM, Carey FA, Kernohan NM. Chromosomal imbalances in gastric and esophageal adenocarcinoma: specific comparative genomic hybridization-detected abnormalities segregate with junctional adenocarcinomas. Genes Chromosomes Cancer 2001;32:50-8.
8. Taniere P, Martel-Planche G, Maurici D, Lombard-Bohas C, Scoazec JY, Montesano R, Berger F, Hainaut P. Molecular and clinical differences between adenocarcinomas of the esophagus and of the gastric cardia. Am J Pathol 2001;158:33-40.
9. Herman JG. Hypermethylation of tumor suppressor genes in cancer. Semin Cancer Biol 1999;9:359-67.
10. Momparler RL, Bovenzi V. DNA methylation and cancer J Cell Physiol 2000;183:145-54.
11. Jones PA, Baylin SB. The fundamental role of epigenetics in cancer. Nat Rev Genet 2002;3:415-28.
12. Esteller M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 2002;62:4519-24.
13. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 2002;61:3225-9.
14. Paz MF, Fraga MF, Avila S, Guo M, Pollan M, Herman J G, Esteller M. A systematic profile of DNA methylation in human cancer cell lines. Cancer Res 2003;63:1114-21.
15. Kawakami K, Brabender J, Lord RV, Groshen S, Greenwald BD, Krasna MJ, Yin J, Fleisher S, Abraham JM, Sidransky D, Huss HAT, Demeester TR, et al. Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. J Natl Cancer Inst 2000;22:1805-11.
16. Eads CA, Danenberg KD, Kawakami K, Saltz LB, Blake C, Shibata D, Danenberg DV, Laird PW. MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 2000;28:E32.
17. Esteller M, Sparks A, Toyotam M, Sanchez-Cespedes M, Capellam G, Peinado MA, Gonzalez S, Tarafa G, Sidransky D, Meltzer SJ, Baylin SB, Herman JG. Analysis of Adenomatous Polyposis Coli promoter hypermethylation in human cancer. Cancer Res 2000;60:4366-71.
18. Kang GH, Shim YH, Jung HY, Kim WH, Ro JY, Rhyu MG. CpG island methylation in premalignant stages of gastric carcinoma. Cancer Res 2001;61:2847-51.
19. ARF gene in gastric cancer. Int J Cancer 2000;87:654-8.
20. To KF, Leung WK, Lee TL, Yu J, Tong JHM, Chan MWY, Ng EKW, Chung SCS, Sung JJY. Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. Int J Cancer 2002;102:623-8.
21. Kim DH, Nelson HH, Wiencke JK, Zheng S, Christiani DC, Wain JC, Mark EJ, Kelsey KT. p16 (INK4A) and histology-specific methylation of CpG islands by exposure to tobacco in non-small cell lung cancer. Cancer Res 2001;61:3419-24.
22. Lehmann U, Celikkaya G, Hasemeier B, Länger F, Kreipe H. Promotor hypermethylation of the Death-associated Protein Kinase gene in breast cancer is associated with the invasive lobular subtype. Cancer Res 2002;62:6634-8.
23. Siewert JR, Stein HJ. Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg 1998;85:1457-9.
24. Sobin LH, Wittekind CH, eds. TNM classification of malignant tumours, 6th ed. New York: Wiley-Liss, Inc., 2002.
25. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histoclinical classification. Acta Path Microbiol Scand 1965;64:31-49.
26. Sarbia M, Loberg C, Wolter M, Arjumand J, Heep H, Reifenberger G, Gabbert HE. Expression of Bcl-2 and amplification of c-myc are frequent in basaloid squamous cell carcinomas of the esophagus. Am J Path 1999;155:1027-32.
27. Eads CA, Lord RV, Wickramasinghe K, Long TI, Kurumboor SK, Bernstein L, Peters JH, DeMeester SR, DeMeester T, Skinner KA, Laird PW. Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res 2001;61:3410-18.
28. Werner M, Becker KF, Keller G, Höfler H. Gastric adenocarcinoma: pathomorphology and molecular pathology. J Cancer Res Clin Oncol 2001;127:207-16.
29. Tokugawa T, Sugihara H, Tani T, Hattori T. Modes of silencing of p16 in development of esophageal squamous cell carcinoma. Cancer Res 2002;62:4938-44.